ENZYME entry: EC 4.2.2.5
Accepted Name |
Chondroitin AC lyase.
|
Alternative Name(s) |
Chondroitin AC eliminase. |
Chondroitin sulfate lyase. |
Chondroitinase. |
Reaction catalysed |
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups |
Comment(s) |
- Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less
well on hyaluronate.
- In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains
comprise a linkage region, a chain cap and a repeat region.
- The repeat region of CS is a repeating disaccharide of glucuronic
acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1-
3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6
of GalNAc and C-2 of GlcA.
- GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming
the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of
DS.
- Both the concentrations and locations of sulfate-ester substituents
vary with glucosaminoglycan source.
- Formerly EC 4.2.99.6.
|
Cross-references |
BRENDA | 4.2.2.5 |
EC2PDB | 4.2.2.5 |
ExplorEnz | 4.2.2.5 |
PRIAM enzyme-specific profiles | 4.2.2.5 |
KEGG Ligand Database for Enzyme Nomenclature | 4.2.2.5 |
IUBMB Enzyme Nomenclature | 4.2.2.5 |
IntEnz | 4.2.2.5 |
MEDLINE | Find literature relating to 4.2.2.5 |
MetaCyc | 4.2.2.5 |
Rhea expert-curated reactions | 4.2.2.5 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-