A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
1,8-cineole synthase.
Alternative Name(s)
1,8-cineole cyclase.
Reaction catalysed
Geranyl diphosphate + H(2)O <=> 1,8-cineole + diphosphate
Zn(2+) or Mn(2+).
  • 1,8-cineole is the main product from the enzyme with just traces of other monoterpenoids.
  • The oxygen atom is derived from water.
  • The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism.
  • However neither intermediate can substitute for geranyl diphosphate.
  • The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)- linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate.
PRIAM enzyme-specific profiles4.2.3.108
KEGG Ligand Database for Enzyme Nomenclature4.2.3.108
IUBMB Enzyme Nomenclature4.2.3.108
MEDLINEFind literature relating to
P0DI76, CIN1_ARATH;  P0DI77, CIN2_ARATH;  O81191, SCS_SALOF;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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