A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.2.3.124
| Accepted Name |
|---|
| 2-deoxy-scyllo-inosose synthase.
|
| Reaction catalysed |
|---|
| D-glucose-6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate |
| Cofactor(s) |
|---|
| Cobalt cation.
|
| Comment(s) |
|---|
- Involved in the biosynthetic pathways of several clinically important
aminocyclitol antibiotics, including kanamycin, butirosin, neomycin
and ribostamycin.
- Requires an NAD(+) cofactor, which is transiently reduced during the
reaction.
- The enzyme from the bacterium Bacillus circulans forms a complex with
the glutamine amidotransferase subunit of pyridoxal 5'-phosphate
synthase (EC 4.3.3.6), which appears to stabilize the complex.
|
| Cross-references |
|---|
| BRENDA | 4.2.3.124 |
| EC2PDB | 4.2.3.124 |
| ExplorEnz | 4.2.3.124 |
| PRIAM enzyme-specific profiles | 4.2.3.124 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.124 |
| IUBMB Enzyme Nomenclature | 4.2.3.124 |
| IntEnz | 4.2.3.124 |
| MEDLINE | Find literature relating to 4.2.3.124 |
| MetaCyc | 4.2.3.124 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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ENZYME /
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ENZYME /
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