Expasy logo

ENZYME

ENZYME entry: EC 4.2.3.124

Accepted Name
2-deoxy-scyllo-inosose synthase
Reaction catalysed
D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate
Comment(s)
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • Requires an NAD(+) cofactor, which is transiently reduced during the reaction.
  • The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex.
Cross-references
BRENDA4.2.3.124
EC2PDB4.2.3.124
ExplorEnz4.2.3.124
PRIAM enzyme-specific profiles4.2.3.124
KEGG Ligand Database for Enzyme Nomenclature4.2.3.124
IUBMB Enzyme Nomenclature4.2.3.124
IntEnz4.2.3.124
MEDLINEFind literature relating to 4.2.3.124
MetaCyc4.2.3.124
Rhea expert-curated reactions4.2.3.124
UniProtKB/Swiss-Prot
Q70KD0, DOIS_MICECQ9S5E2, DOIS_NIACIQ2MFP1, DOIS_STREY
Q53U19, DOIS_STRFRQ6L738, DOIS_STRKNQ2MF70, DOIS_STRLV
Q4R0W3, DOIS_STRRIQ2MF16, DOIS_STRSD

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-