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ENZYME entry: EC 4.2.3.124

Accepted Name
2-deoxy-scyllo-inosose synthase.
Reaction catalysed
D-glucose-6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate
Cofactor(s)
Cobalt cation.
Comment(s)
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • Requires an NAD(+) cofactor, which is transiently reduced during the reaction.
  • The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex.
Cross-references
BRENDA4.2.3.124
EC2PDB4.2.3.124
ExplorEnz4.2.3.124
PRIAM enzyme-specific profiles4.2.3.124
KEGG Ligand Database for Enzyme Nomenclature4.2.3.124
IUBMB Enzyme Nomenclature4.2.3.124
IntEnz4.2.3.124
MEDLINEFind literature relating to 4.2.3.124
MetaCyc4.2.3.124
Rhea expert-curated reactions4.2.3.124
UniProtKB/Swiss-Prot
Q9S5E2, DOIS_BACCI;  Q70KD0, DOIS_MICEC;  Q53U19, DOIS_STRFR;  
Q6L738, DOIS_STRKN;  Q2MF70, DOIS_STRLV;  Q4R0W3, DOIS_STRRI;  
Q2MFP1, DOIS_STRRY;  Q2MF16, DOIS_STRSD;  

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