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ENZYME

ENZYME entry: EC 4.2.3.17

PURL: https://purl.expasy.org/enzyme/EC/4.2.3.17
Accepted Name
taxadiene synthase
Alternative Name(s)
taxa-4(5),11(12)-diene synthase
taxadiene cyclase
Reaction catalysed
(2E,6E,10E)-geranylgeranyl diphosphate = taxa-4(5),11(12)-diene + diphosphate
Comment(s)
  • This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel).
  • The cyclization involves a 1,5-hydride shift.
Cross-references
BRENDA4.2.3.17
EC2PDB4.2.3.17
ExplorEnz4.2.3.17
KEGG Ligand Database for Enzyme Nomenclature4.2.3.17
IUBMB Enzyme Nomenclature4.2.3.17
MEDLINEFind literature relating to 4.2.3.17
MetaCyc4.2.3.17
Rhea expert-curated reactions4.2.3.17
UniProtKB/Swiss-Prot
Q93YA3, TASY_TAXBAQ41594, TASY_TAXBRQ9FT37, TASY_TAXCH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-