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ENZYME entry: EC 4.2.3.194

Accepted Name
(-)-drimenol synthase.
Alternative Name(s)
drimenol cyclase.
farnesyl pyrophosphate:drimenol cyclase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate
Comment(s)
  • Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper).
  • The enzyme does not act on farnesol or drimenol diphosphate.
  • Using 18-oxygen labeled water 18-oxygen was incorporated suggesting involvement of a stabilized carbocation or an equivalent species.
  • Formerly EC 3.1.7.7.
Cross-references
BRENDA4.2.3.194
EC2PDB4.2.3.194
ExplorEnz4.2.3.194
PRIAM enzyme-specific profiles4.2.3.194
KEGG Ligand Database for Enzyme Nomenclature4.2.3.194
IUBMB Enzyme Nomenclature4.2.3.194
IntEnz4.2.3.194
MEDLINEFind literature relating to 4.2.3.194
MetaCyc4.2.3.194
Rhea expert-curated reactions4.2.3.194
UniProtKB/Swiss-Prot
A0A0U5GNT1, DRTB_ASPCI;  W0FFD7, DS_PERHD;  U3KYL2, DS_VALOF;  

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