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ENZYME

ENZYME entry: EC 4.2.3.203

PURL: https://purl.expasy.org/enzyme/EC/4.2.3.203
Accepted Name
isoelisabethatriene synthase
Reaction catalysed
(2E,6E,10E)-geranylgeranyl diphosphate = isoelisabethatriene + diphosphate
Comment(s)
  • Isolated from the bacterium Streptomyces clavuligerus.
  • The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain.
  • The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201 and EC 4.2.3.202.
Cross-references
BRENDA4.2.3.203
EC2PDB4.2.3.203
ExplorEnz4.2.3.203
KEGG Ligand Database for Enzyme Nomenclature4.2.3.203
IUBMB Enzyme Nomenclature4.2.3.203
MEDLINEFind literature relating to 4.2.3.203
MetaCyc4.2.3.203
Rhea expert-curated reactions4.2.3.203
UniProtKB/Swiss-Prot
D5SK09, HPS_STRCL

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