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ENZYME entry: EC 4.2.3.23

Accepted Name
Germacrene-A synthase.
Alternative Name(s)
(+)-(10R)-germacrene A synthase.
(+)-germacrene A synthase.
GAS.
Germacrene A synthase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate
Cofactor(s)
Mg(2+).
Comment(s)
While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 from some species and EC 4.2.3.21, it is the sole sesquiterpenoid product formed in chicory.
Cross-references
BRENDA4.2.3.23
EC2PDB4.2.3.23
ExplorEnz4.2.3.23
PRIAM enzyme-specific profiles4.2.3.23
KEGG Ligand Database for Enzyme Nomenclature4.2.3.23
IUBMB Enzyme Nomenclature4.2.3.23
IntEnz4.2.3.23
MEDLINEFind literature relating to 4.2.3.23
MetaCyc4.2.3.23
UniProtKB/Swiss-Prot
A8NE23, COP3_COPC7;  Q4U3F7, GAS1_HELAN;  B0FGA9, GAS2_HELAN;  
Q8LSC3, GASL_CICIN;  Q8LSC2, GASS_CICIN;  B6SCF6, STS2_HUMLU;  
Q49SP5, TPGAS_POGCB;  I6QSN0, TPS3_MATCR;  

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