ENZYME entry: EC 4.2.3.9
Accepted Name |
Aristolochene synthase.
|
Alternative Name(s) |
Sesquiterpene cyclase. |
Trans,trans-farnesyl diphosphate aristolochene-lyase. |
Reaction catalysed |
(2E,6E)-farnesyl diphosphate <=> aristolochene + diphosphate |
Cofactor(s) |
Mg(2+); Mn(2+).
|
Comment(s) |
- The initial internal cyclization produces the monocyclic intermediate
germacrene A; further cyclization and methyl transfer converts the
intermediate into aristolochene.
- While in some species germacrene A remains as an enzyme-bound
intermediate, it has been shown to be a minor product of the reaction
in Penicillium roqueforti (see also EC 4.2.3.23).
- Aristolochene is the likely parent compound for a number of
sesquiterpenes produced by filamentous fungi.
- Formerly EC 2.5.1.40 and EC 4.1.99.7.
|
Cross-references |
BRENDA | 4.2.3.9 |
EC2PDB | 4.2.3.9 |
ExplorEnz | 4.2.3.9 |
PRIAM enzyme-specific profiles | 4.2.3.9 |
KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.9 |
IUBMB Enzyme Nomenclature | 4.2.3.9 |
IntEnz | 4.2.3.9 |
MEDLINE | Find literature relating to 4.2.3.9 |
MetaCyc | 4.2.3.9 |
Rhea expert-curated reactions | 4.2.3.9 |
UniProtKB/Swiss-Prot |
|
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