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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Aristolochene synthase.
Alternative Name(s)
Sesquiterpene cyclase.
Trans,trans-farnesyl diphosphate aristolochene-lyase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate <=> aristolochene + diphosphate
Mg(2+); Mn(2+).
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC and EC
PRIAM enzyme-specific profiles4.2.3.9
KEGG Ligand Database for Enzyme Nomenclature4.2.3.9
IUBMB Enzyme Nomenclature4.2.3.9
MEDLINEFind literature relating to
Q9UR08, ARIS_ASPTE;  Q03471, PRX2_PENRO;  B6H063, PRX2_PENRW;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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