Expasy logo

ENZYME

ENZYME entry: EC 4.2.3.9

PURL: https://purl.expasy.org/enzyme/EC/4.2.3.9
Accepted Name
aristolochene synthase
Alternative Name(s)
sesquiterpene cyclase
trans,trans-farnesyl diphosphate aristolochene-lyase
Reaction catalysed
(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate
Comment(s)
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23).
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC 2.5.1.40 and EC 4.1.99.7.
Cross-references
Rhea expert-curated reactions4.2.3.9
ExplorEnz4.2.3.9
IUBMB Enzyme Nomenclature4.2.3.9
UniProtKB/Swiss-Prot
Q9UR08, ARIS_ASPTEW6Q4Q9, PRX2_PENRFQ03471, PRX2_PENRO
B6H063, PRX2_PENRWA0A0A2JB87, TS1_PENEN
BRENDA4.2.3.9
MetaCyc4.2.3.9
KEGG Ligand Database for Enzyme Nomenclature4.2.3.9
EC2PDB4.2.3.9
MEDLINEFind literature relating to 4.2.3.9

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-