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ENZYME

ENZYME entry: EC 4.2.3.9

Accepted Name
aristolochene synthase
Alternative Name(s)
sesquiterpene cyclase
trans,trans-farnesyl diphosphate aristolochene-lyase
Reaction catalysed
(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate
Comment(s)
  • The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene.
  • While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23).
  • Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.
  • Formerly EC 2.5.1.40 and EC 4.1.99.7.
Cross-references
BRENDA4.2.3.9
EC2PDB4.2.3.9
ExplorEnz4.2.3.9
PRIAM enzyme-specific profiles4.2.3.9
KEGG Ligand Database for Enzyme Nomenclature4.2.3.9
IUBMB Enzyme Nomenclature4.2.3.9
IntEnz4.2.3.9
MEDLINEFind literature relating to 4.2.3.9
MetaCyc4.2.3.9
Rhea expert-curated reactions4.2.3.9
UniProtKB/Swiss-Prot
Q9UR08, ARIS_ASPTEW6Q4Q9, PRX2_PENRFQ03471, PRX2_PENRO
B6H063, PRX2_PENRWA0A0A2JB87, TS1_PENEN

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