ENZYME entry: EC 4.2.3.9
| Accepted Name |
|---|
| Aristolochene synthase.
|
| Alternative Name(s) |
|---|
| Sesquiterpene cyclase. |
| Trans,trans-farnesyl diphosphate aristolochene-lyase. |
| Reaction catalysed |
|---|
| (2E,6E)-farnesyl diphosphate <=> aristolochene + diphosphate |
| Cofactor(s) |
|---|
| Mg(2+); Mn(2+).
|
| Comment(s) |
|---|
- The initial internal cyclization produces the monocyclic intermediate
germacrene A; further cyclization and methyl transfer converts the
intermediate into aristolochene.
- While in some species germacrene A remains as an enzyme-bound
intermediate, it has been shown to be a minor product of the reaction
in Penicillium roqueforti (see also EC 4.2.3.23).
- Aristolochene is the likely parent compound for a number of
sesquiterpenes produced by filamentous fungi.
- Formerly EC 2.5.1.40 and EC 4.1.99.7.
|
| Cross-references |
|---|
| BRENDA | 4.2.3.9 |
| EC2PDB | 4.2.3.9 |
| ExplorEnz | 4.2.3.9 |
| PRIAM enzyme-specific profiles | 4.2.3.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.9 |
| IUBMB Enzyme Nomenclature | 4.2.3.9 |
| IntEnz | 4.2.3.9 |
| MEDLINE | Find literature relating to 4.2.3.9 |
| MetaCyc | 4.2.3.9 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-