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ENZYME

ENZYME entry: EC 4.3.1.18

Accepted Name
D-serine ammonia-lyase
Alternative Name(s)
D-hydroxy amino acid dehydratase
D-serine deaminase
D-serine dehydrase
D-serine dehydratase
D-serine dehydratase (deaminating)
D-serine hydrolase
D-serine hydro-lyase (deaminating)
Reaction catalysed
D-serine <=> NH4(+) + pyruvate
Comment(s)
  • The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Also acts, slowly, on D-threonine.
  • Formerly EC 4.2.1.14.
Cross-references
BRENDA4.3.1.18
EC2PDB4.3.1.18
ExplorEnz4.3.1.18
PRIAM enzyme-specific profiles4.3.1.18
KEGG Ligand Database for Enzyme Nomenclature4.3.1.18
IUBMB Enzyme Nomenclature4.3.1.18
IntEnz4.3.1.18
MEDLINEFind literature relating to 4.3.1.18
MetaCyc4.3.1.18
Rhea expert-curated reactions4.3.1.18
UniProtKB/Swiss-Prot
A0A8V1ABE9, DSD1_CHICKQ9US35, DSD1_SCHPOP53095, DSD1_YEAST
Q0TF95, SDHD1_ECOL5Q1R901, SDHD1_ECOUTQ0T953, SDHD2_ECOL5
Q1R2Q6, SDHD2_ECOUTQ6FDC1, SDHD_ACIADB7I8P7, SDHD_ACIB5
B2HVC6, SDHD_ACIBCA3M3B1, SDHD_ACIBTB9MIR7, SDHD_ACIET
A1W838, SDHD_ACISJA0KI76, SDHD_AERHHA4SPX2, SDHD_AERS4
Q5WGL6, SDHD_ALKCKC3L7G5, SDHD_BACACA0RCF8, SDHD_BACAH
Q81S85, SDHD_BACANQ73AC5, SDHD_BACC1B7IR88, SDHD_BACC2
C1EPF1, SDHD_BACC3B7HID8, SDHD_BACC4B7HMG6, SDHD_BACC7
Q81F73, SDHD_BACCRQ63D23, SDHD_BACCZQ6HKG3, SDHD_BACHK
A9VPH9, SDHD_BACMKP54555, SDHD_BACSUQ396Y3, SDHD_BURL3
A3P975, SDHD_BURP0Q3JJ76, SDHD_BURP1A3NNQ0, SDHD_BURP6
Q63IF8, SDHD_BURPSQ2T8Q2, SDHD_BURTAQ3AFZ5, SDHD_CARHZ
Q7NUP9, SDHD_CHRVOA8ACI7, SDHD_CITK8Q47V69, SDHD_COLP3
Q46X58, SDHD_CUPPJQ24WR0, SDHD_DESHYA7ZPH2, SDHD_ECO24
B7MH26, SDHD_ECO45B7LBR9, SDHD_ECO55Q8XCK5, SDHD_ECO57
B5YYW7, SDHD_ECO5EB7MY25, SDHD_ECO81B7M6N5, SDHD_ECO8A
C4ZVQ3, SDHD_ECOBWB1X9N9, SDHD_ECODHA8A2M0, SDHD_ECOHS
A1ADP3, SDHD_ECOK1Q8FFF4, SDHD_ECOL6B1IX96, SDHD_ECOLC
P00926, SDHD_ECOLIB7N5W6, SDHD_ECOLUB6I6R7, SDHD_ECOSE
B7LK20, SDHD_ESCF3Q8RFX6, SDHD_FUSNNQ75TC9, SDHD_GEOKA
Q75TH5, SDHD_GEOSEQ2SHX7, SDHD_HAHCHQ9KC12, SDHD_HALH5
Q0I5V1, SDHD_HISS1B0UWV3, SDHD_HISS2Q88TY1, SDHD_LACPL
B2GBP8, SDHD_LIMF3Q04G28, SDHD_OENOBA1TPW5, SDHD_PARC0
Q03DF6, SDHD_PEDPAQ7N5H9, SDHD_PHOLLQ6LHF5, SDHD_PHOPR
A1VWK8, SDHD_POLNAA6V271, SDHD_PSEA7B7V2Y0, SDHD_PSEA8
Q02QJ1, SDHD_PSEABQ9HYN9, SDHD_PSEAEA4XXF3, SDHD_PSEMY
A5W4Y8, SDHD_PSEP1B0KGK3, SDHD_PSEPGB3PYT5, SDHD_RHIE6
B5ZNC1, SDHD_RHILWB5EY75, SDHD_SALA4A9MKH2, SDHD_SALAR
Q57I32, SDHD_SALCHB5FMC1, SDHD_SALDCB5QU31, SDHD_SALEP
B5RG23, SDHD_SALG2B4TA53, SDHD_SALHSB4SY68, SDHD_SALNS
Q5PKR3, SDHD_SALPAA9MWI4, SDHD_SALPBC0Q241, SDHD_SALPC
B5BII6, SDHD_SALPKB4TMW9, SDHD_SALSVQ8Z2L4, SDHD_SALTI
Q8ZL08, SDHD_SALTYA8GES6, SDHD_SERP5Q31YA5, SDHD_SHIBS
Q32DH8, SDHD_SHIDSQ0T2D1, SDHD_SHIF8Q83MK8, SDHD_SHIFL
Q3YZG4, SDHD_SHISSA6UB95, SDHD_SINMWQ4A041, SDHD_STAS1
A7MYG2, SDHD_VIBC1A5F0M6, SDHD_VIBC3Q9KL72, SDHD_VIBCH
C3LWD9, SDHD_VIBCMQ87QA2, SDHD_VIBPAA1JJW5, SDHD_YERE8
Q2PGG3, SRR_ARATHA0JNI4, SRR_BOVINQ54HH2, SRR_DICDI
Q9GZT4, SRR_HUMANQ9QZX7, SRR_MOUSEA2XWA9, SRR_ORYSI
Q7XSN8, SRR_ORYSJQ76EQ0, SRR_RATO59791, SRR_SCHPO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-