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ENZYME

ENZYME entry: EC 4.3.1.18

Accepted Name
D-serine ammonia-lyase
Alternative Name(s)
D-hydroxy amino acid dehydratase
D-serine deaminase
D-serine dehydrase
D-serine dehydratase
D-serine dehydratase (deaminating)
D-serine hydrolase
D-serine hydro-lyase (deaminating)
Reaction catalysed
D-serine <=> NH4(+) + pyruvate
Comment(s)
  • The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Also acts, slowly, on D-threonine.
  • Formerly EC 4.2.1.14.
Cross-references
BRENDA4.3.1.18
EC2PDB4.3.1.18
ExplorEnz4.3.1.18
PRIAM enzyme-specific profiles4.3.1.18
KEGG Ligand Database for Enzyme Nomenclature4.3.1.18
IUBMB Enzyme Nomenclature4.3.1.18
IntEnz4.3.1.18
MEDLINEFind literature relating to 4.3.1.18
MetaCyc4.3.1.18
Rhea expert-curated reactions4.3.1.18
UniProtKB/Swiss-Prot
A0A8V1ABE9, DSD1_CHICKQ9US35, DSD1_SCHPOP53095, DSD1_YEAST
Q0TF95, SDHD1_ECOL5Q1R901, SDHD1_ECOUTQ0T953, SDHD2_ECOL5
Q1R2Q6, SDHD2_ECOUTQ6FDC1, SDHD_ACIADB7I8P7, SDHD_ACIB5
B2HVC6, SDHD_ACIBCA3M3B1, SDHD_ACIBTB9MIR7, SDHD_ACIET
A1W838, SDHD_ACISJA0KI76, SDHD_AERHHA4SPX2, SDHD_AERS4
C3L7G5, SDHD_BACACA0RCF8, SDHD_BACAHQ81S85, SDHD_BACAN
Q73AC5, SDHD_BACC1B7IR88, SDHD_BACC2C1EPF1, SDHD_BACC3
B7HID8, SDHD_BACC4B7HMG6, SDHD_BACC7Q81F73, SDHD_BACCR
Q63D23, SDHD_BACCZQ6HKG3, SDHD_BACHKA9VPH9, SDHD_BACMK
P54555, SDHD_BACSUQ396Y3, SDHD_BURL3A3P975, SDHD_BURP0
Q3JJ76, SDHD_BURP1A3NNQ0, SDHD_BURP6Q63IF8, SDHD_BURPS
Q2T8Q2, SDHD_BURTAQ3AFZ5, SDHD_CARHZQ7NUP9, SDHD_CHRVO
A8ACI7, SDHD_CITK8Q47V69, SDHD_COLP3Q46X58, SDHD_CUPPJ
Q24WR0, SDHD_DESHYA7ZPH2, SDHD_ECO24B7MH26, SDHD_ECO45
B7LBR9, SDHD_ECO55Q8XCK5, SDHD_ECO57B5YYW7, SDHD_ECO5E
B7MY25, SDHD_ECO81B7M6N5, SDHD_ECO8AC4ZVQ3, SDHD_ECOBW
B1X9N9, SDHD_ECODHA8A2M0, SDHD_ECOHSA1ADP3, SDHD_ECOK1
Q8FFF4, SDHD_ECOL6B1IX96, SDHD_ECOLCP00926, SDHD_ECOLI
B7N5W6, SDHD_ECOLUB6I6R7, SDHD_ECOSEB7LK20, SDHD_ESCF3
Q8RFX6, SDHD_FUSNNQ75TC9, SDHD_GEOKAQ75TH5, SDHD_GEOSE
Q2SHX7, SDHD_HAHCHQ9KC12, SDHD_HALH5Q0I5V1, SDHD_HISS1
B0UWV3, SDHD_HISS2Q88TY1, SDHD_LACPLB2GBP8, SDHD_LIMF3
Q04G28, SDHD_OENOBA1TPW5, SDHD_PARC0Q03DF6, SDHD_PEDPA
Q7N5H9, SDHD_PHOLLQ6LHF5, SDHD_PHOPRA1VWK8, SDHD_POLNA
A6V271, SDHD_PSEA7B7V2Y0, SDHD_PSEA8Q02QJ1, SDHD_PSEAB
Q9HYN9, SDHD_PSEAEA4XXF3, SDHD_PSEMYA5W4Y8, SDHD_PSEP1
B0KGK3, SDHD_PSEPGB3PYT5, SDHD_RHIE6B5ZNC1, SDHD_RHILW
B5EY75, SDHD_SALA4A9MKH2, SDHD_SALARQ57I32, SDHD_SALCH
B5FMC1, SDHD_SALDCB5QU31, SDHD_SALEPB5RG23, SDHD_SALG2
B4TA53, SDHD_SALHSB4SY68, SDHD_SALNSQ5PKR3, SDHD_SALPA
A9MWI4, SDHD_SALPBC0Q241, SDHD_SALPCB5BII6, SDHD_SALPK
B4TMW9, SDHD_SALSVQ8Z2L4, SDHD_SALTIQ8ZL08, SDHD_SALTY
A8GES6, SDHD_SERP5Q31YA5, SDHD_SHIBSQ32DH8, SDHD_SHIDS
Q0T2D1, SDHD_SHIF8Q83MK8, SDHD_SHIFLQ3YZG4, SDHD_SHISS
Q5WGL6, SDHD_SHOC1A6UB95, SDHD_SINMWQ4A041, SDHD_STAS1
A7MYG2, SDHD_VIBC1A5F0M6, SDHD_VIBC3Q9KL72, SDHD_VIBCH
C3LWD9, SDHD_VIBCMQ87QA2, SDHD_VIBPAA1JJW5, SDHD_YERE8
Q2PGG3, SRR_ARATHA0JNI4, SRR_BOVINQ54HH2, SRR_DICDI
Q9GZT4, SRR_HUMANQ9QZX7, SRR_MOUSEA2XWA9, SRR_ORYSI
Q7XSN8, SRR_ORYSJQ76EQ0, SRR_RATO59791, SRR_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-