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ENZYME entry: EC 4.3.1.23

Accepted Name
Tyrosine ammonia-lyase.
Alternative Name(s)
L-tyrosine ammonia-lyase.
TAL.
Tyrase.
Reaction catalysed
L-tyrosine <=> trans-p-hydroxycinnamate + ammonia
Cofactor(s)
MIO.
Comment(s)
  • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.24 and EC 4.3.1.25.
  • Far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides.
  • Formerly EC 4.3.1.5.
Cross-references
PROSITEPDOC00424
BRENDA4.3.1.23
EC2PDB4.3.1.23
ExplorEnz4.3.1.23
PRIAM enzyme-specific profiles4.3.1.23
KEGG Ligand Database for Enzyme Nomenclature4.3.1.23
IUBMB Enzyme Nomenclature4.3.1.23
IntEnz4.3.1.23
MEDLINEFind literature relating to 4.3.1.23
MetaCyc4.3.1.23
Rhea expert-curated reactions4.3.1.23
UniProtKB/Swiss-Prot
Q1LRV9, TALY_CUPMC;  Q3IWB0, TALY_RHOS4;  Q0VZ68, TAM_CHOCO;  
B8ZV93, TAM_MYXFU;  B8ZV94, TAM_MYXSM;  Q8GMG0, TAM_STRGL;  

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