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ENZYME

ENZYME entry: EC 4.3.1.3

Accepted Name
histidine ammonia-lyase
Alternative Name(s)
histidase
histidinase
histidine alpha-deaminase
Reaction catalysed
L-histidine <=> NH4(+) + trans-urocanate
Comment(s)
  • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25.
  • Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.
Cross-references
BRENDA4.3.1.3
EC2PDB4.3.1.3
ExplorEnz4.3.1.3
PRIAM enzyme-specific profiles4.3.1.3
KEGG Ligand Database for Enzyme Nomenclature4.3.1.3
IUBMB Enzyme Nomenclature4.3.1.3
IntEnz4.3.1.3
MEDLINEFind literature relating to 4.3.1.3
MetaCyc4.3.1.3
Rhea expert-curated reactions4.3.1.3
UniProtKB/Swiss-Prot
Q556V9, HALL_DICDIQ20502, HUTH1_CAEELQ8RFC2, HUTH1_FUSNN
Q8RDU4, HUTH2_FUSNNA1TRE4, HUTH_ACIACA5FZB9, HUTH_ACICJ
Q8U8Z7, HUTH_AGRFCQ9KWE4, HUTH_AGRRHB9JDC0, HUTH_AGRRK
Q5E0C6, HUTH_ALIF1B5ETN1, HUTH_ALIFMQ5WAZ6, HUTH_ALKCK
A6TSX0, HUTH_ALKMQA8MF64, HUTH_ALKOOB9K288, HUTH_ALLAM
B8J950, HUTH_ANAD2Q2IIV4, HUTH_ANADEB4UC43, HUTH_ANASK
Q5NZX8, HUTH_AROAEC3P4M2, HUTH_BACAAC3L982, HUTH_BACAC
A0RH39, HUTH_BACAHQ81Y45, HUTH_BACANB7JI80, HUTH_BACC0
Q733H8, HUTH_BACC1B7ISJ2, HUTH_BACC2C1EN93, HUTH_BACC3
B7HCD0, HUTH_BACC4B7HKJ1, HUTH_BACC7A7GR00, HUTH_BACCN
B9IUH0, HUTH_BACCQQ81AC6, HUTH_BACCRQ637H8, HUTH_BACCZ
Q6HFE9, HUTH_BACHKA9VPT8, HUTH_BACMKP10944, HUTH_BACSU
A7ZAE4, HUTH_BACVZQ6G3U8, HUTH_BARHEQ6FZP9, HUTH_BARQU
A9IVW5, HUTH_BART1A7YWP4, HUTH_BOVINQ89GV3, HUTH_BRADU
A5EQB7, HUTH_BRASBA4YNK7, HUTH_BRASOB2SD96, HUTH_BRUA1
Q2YIL6, HUTH_BRUA2A6WYU8, HUTH_BRUA4Q579E8, HUTH_BRUAB
A9MCL0, HUTH_BRUC2A5VVJ6, HUTH_BRUO2A9WVU3, HUTH_BRUSI
Q8FVB4, HUTH_BRUSUB1YT80, HUTH_BURA4A0K8U6, HUTH_BURCH
B4EDX5, HUTH_BURCJQ0BDK6, HUTH_BURCMQ39EP0, HUTH_BURL3
A9AGP7, HUTH_BURM1A3MLT7, HUTH_BURM7A2SA96, HUTH_BURM9
Q62LJ6, HUTH_BURMAB1JV50, HUTH_BURO0Q1BHY5, HUTH_BURO1
A3NXA3, HUTH_BURP0A3NBH0, HUTH_BURP6Q63SH6, HUTH_BURPS
A4JG46, HUTH_BURVGQ8RBH4, HUTH_CALS4B0SYU6, HUTH_CAUSK
P58082, HUTH_CAUVCB8H2S1, HUTH_CAUVNA3PK23, HUTH_CERS1
Q3J289, HUTH_CERS4B9KSW6, HUTH_CERSKQ11E18, HUTH_CHESB
A9WHT8, HUTH_CHLAAB9LLY0, HUTH_CHLSYQ7P188, HUTH_CHRVO
A8AJ15, HUTH_CITK8Q891Q1, HUTH_CLOTEC1CWB4, HUTH_DEIDV
Q9RZ06, HUTH_DEIRAQ6AKP3, HUTH_DESPSQ54JI7, HUTH_DICDI
A4W8B5, HUTH_ENT38Q5L310, HUTH_GEOKAC5D4K1, HUTH_GEOSW
A4IK90, HUTH_GEOTNQ7NCB3, HUTH_GLOVIA9H863, HUTH_GLUDA
Q5FRR8, HUTH_GLUOXQ9KBE6, HUTH_HALH5B0R544, HUTH_HALS3
Q9HQD5, HUTH_HALSAP42357, HUTH_HUMANQ0BZK2, HUTH_HYPNA
Q5QV30, HUTH_IDILOB5XZ79, HUTH_KLEP3A6T6L1, HUTH_KLEP7
Q1IRT8, HUTH_KORVEQ5X5I5, HUTH_LEGPAA5IBM2, HUTH_LEGPC
Q5ZVR0, HUTH_LEGPHQ5WWW8, HUTH_LEGPLB9E7E0, HUTH_MACCJ
Q0AP92, HUTH_MARMMB8II08, HUTH_METNOB0UQ15, HUTH_METS4
P35492, HUTH_MOUSEQ1D6R1, HUTH_MYXXDB2A3D9, HUTH_NATTJ
A1AZX9, HUTH_PARDPB2T2Y2, HUTH_PARPJB4RED8, HUTH_PHEZH
Q7N296, HUTH_PHOLLQ6LQ56, HUTH_PHOPRQ15X40, HUTH_PSEA6
B7V3J1, HUTH_PSEA8Q02ER8, HUTH_PSEABQ9HU85, HUTH_PSEAE
Q8VMR3, HUTH_PSEFSQ3KJE6, HUTH_PSEPFQ88CZ7, HUTH_PSEPK
P21310, HUTH_PSEPUQ87UM1, HUTH_PSESMQ1Q9E4, HUTH_PSYCK
A1STQ3, HUTH_PSYINA5WDR1, HUTH_PSYWFQ8XW29, HUTH_RALN1
P21213, HUTH_RATQ983I0, HUTH_RHILOO31197, HUTH_RHIME
B6IWC6, HUTH_RHOCSQ2RUU3, HUTH_RHORTQ162E2, HUTH_ROSDO
Q5LRD8, HUTH_RUEPOB5F069, HUTH_SALA4A9MJE9, HUTH_SALAR
Q57RG6, HUTH_SALCHB5FP58, HUTH_SALDCB5QX62, HUTH_SALEP
B5R758, HUTH_SALG2B4TC45, HUTH_SALHSB4SZJ4, HUTH_SALNS
Q5PG61, HUTH_SALPAA9MTJ1, HUTH_SALPBC0PWX9, HUTH_SALPC
B5BC34, HUTH_SALPKB4TQT6, HUTH_SALSVQ8Z896, HUTH_SALTI
Q8ZQQ9, HUTH_SALTYQ8EKJ4, HUTH_SHEONA8HA91, HUTH_SHEPA
B8CGY5, HUTH_SHEPWA8G1S5, HUTH_SHESHB1KP55, HUTH_SHEWM
A9GFW6, HUTH_SORC5Q1GSH0, HUTH_SPHALA6TXF8, HUTH_STAA2
Q2FKP8, HUTH_STAA3Q2G2P7, HUTH_STAA8A5INP9, HUTH_STAA9
Q2YUR3, HUTH_STAABQ5HJY8, HUTH_STAACA6QD47, HUTH_STAAE
P64415, HUTH_STAAMP64416, HUTH_STAANQ6GKT7, HUTH_STAAR
Q6GD82, HUTH_STAASA8YYT1, HUTH_STAATQ8NYY3, HUTH_STAAW
Q4A173, HUTH_STAS1Q93TX3, HUTH_STIAUQ82I33, HUTH_STRAW
Q9EWW1, HUTH_STRCOA8AZ70, HUTH_STRGCP24221, HUTH_STRGR
P58083, HUTH_STRP1P0DB74, HUTH_STRP3Q5X9K4, HUTH_STRP6
Q8NZ46, HUTH_STRP8A2RGS5, HUTH_STRPGP0DB75, HUTH_STRPQ
B5XIY2, HUTH_STRPZA3CL24, HUTH_STRSVQ67JH4, HUTH_SYMTH
Q9HLI6, HUTH_THEACQ978N8, HUTH_THEVOQ73Q56, HUTH_TREDE
Q9KSQ4, HUTH_VIBCHQ87Q77, HUTH_VIBPAQ8DA21, HUTH_VIBVU
Q7MK58, HUTH_VIBVYQ8PLZ8, HUTH_XANACQ4UTB9, HUTH_XANC8
B0RUX3, HUTH_XANCBQ8PAA7, HUTH_XANCPA1JSW6, HUTH_YERE8
Q8ZA10, HUTH_YERPEQ664B8, HUTH_YERPSQ8YD09, HUTIH_BRUME

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-