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ENZYME

ENZYME entry: EC 4.3.1.30

Accepted Name
dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
Reaction catalysed
AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)
Comment(s)
  • The enzyme, which is a member of the 'AdoMet radical' (radical SAM) family, is involved in biosynthesis of TDP-alpha-D-desosamine.
  • The reaction starts by the transfer of an electron from the reduced form of the enzyme's [4Fe-4S] cluster to S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5'-yl, which attacks the sugar substrate.
Cross-references
BRENDA4.3.1.30
EC2PDB4.3.1.30
ExplorEnz4.3.1.30
PRIAM enzyme-specific profiles4.3.1.30
KEGG Ligand Database for Enzyme Nomenclature4.3.1.30
IUBMB Enzyme Nomenclature4.3.1.30
IntEnz4.3.1.30
MEDLINEFind literature relating to 4.3.1.30
MetaCyc4.3.1.30
Rhea expert-curated reactions4.3.1.30
UniProtKB/Swiss-Prot
Q9ZGH1, DESII_STRVZ

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