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ENZYME entry: EC 4.3.2.2

Accepted Name
Adenylosuccinate lyase.
Alternative Name(s)
Adenylosuccinase.
Succino AMP-lyase.
Reaction catalysed
  • N(6)-(1,2-dicarboxyethyl)AMP <=> fumarate + AMP
  • (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate <=> fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Comment(s)
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.
Cross-references
PROSITEPDOC00147
BRENDA4.3.2.2
EC2PDB4.3.2.2
ExplorEnz4.3.2.2
PRIAM enzyme-specific profiles4.3.2.2
KEGG Ligand Database for Enzyme Nomenclature4.3.2.2
IUBMB Enzyme Nomenclature4.3.2.2
IntEnz4.3.2.2
MEDLINEFind literature relating to 4.3.2.2
MetaCyc4.3.2.2
Rhea expert-curated reactions4.3.2.2
UniProtKB/Swiss-Prot
O66856, PUR8_AQUAE;  O28041, PUR8_ARCFU;  P12047, PUR8_BACSU;  
A3KN12, PUR8_BOVIN;  P57351, PUR8_BUCAI;  Q8K9Q7, PUR8_BUCAP;  
Q89AM3, PUR8_BUCBP;  Q60Q90, PUR8_CAEBR;  Q21774, PUR8_CAEEL;  
P21265, PUR8_CHICK;  Q9RSE6, PUR8_DEIRA;  Q54J34, PUR8_DICDI;  
P0AB90, PUR8_ECOL6;  P0AB89, PUR8_ECOLI;  P44797, PUR8_HAEIN;  
Q9ZKA2, PUR8_HELPJ;  P56468, PUR8_HELPY;  P30566, PUR8_HUMAN;  
A5IGB3, PUR8_LEGPC;  Q5ZXD1, PUR8_LEGPH;  Q8HXY5, PUR8_MACFA;  
Q58339, PUR8_METJA;  O27580, PUR8_METTH;  P54822, PUR8_MOUSE;  
Q9I0K9, PUR8_PSEAE;  Q9UZ99, PUR8_PYRAB;  O58582, PUR8_PYRHO;  
O60105, PUR8_SCHPO;  P52201, PUR8_SPICI;  Q2FFI7, PUR8_STAA3;  
Q2G2S0, PUR8_STAA8;  Q2YU66, PUR8_STAAB;  Q5HEL4, PUR8_STAAC;  
Q99SX9, PUR8_STAAM;  Q7A4Q3, PUR8_STAAN;  Q6GFE9, PUR8_STAAR;  
Q6G825, PUR8_STAAS;  Q7A0G9, PUR8_STAAW;  Q5HN26, PUR8_STAEQ;  
Q8CRT6, PUR8_STAES;  Q4L7M3, PUR8_STAHJ;  Q49YV3, PUR8_STAS1;  
P72478, PUR8_STRMU;  P74384, PUR8_SYNY3;  Q9X0I0, PUR8_THEMA;  
A0A0H3AL67, PUR8_VIBC3;  Q05911, PUR8_YEAST;  

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