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ENZYME

ENZYME entry: EC 4.3.2.6

Accepted Name
gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
Reaction catalysed
gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B
Comment(s)
  • The enzyme catalyzes the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L- glutamate of the side chain, releasing it as the cyclic 5-oxoproline.
Cross-references
BRENDA4.3.2.6
EC2PDB4.3.2.6
ExplorEnz4.3.2.6
PRIAM enzyme-specific profiles4.3.2.6
KEGG Ligand Database for Enzyme Nomenclature4.3.2.6
IUBMB Enzyme Nomenclature4.3.2.6
IntEnz4.3.2.6
MEDLINEFind literature relating to 4.3.2.6
MetaCyc4.3.2.6
Rhea expert-curated reactions4.3.2.6
UniProtKB/Swiss-Prot
Q4H4F0, BTRG_NIACI

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