ENZYME entry: EC 4.3.2.9
| Accepted Name |
|---|
| Gamma-glutamylcyclotransferase.
|
| Alternative Name(s) |
|---|
| GGCT. |
| Reaction catalysed |
|---|
| Alpha-(gamma-L-glutamyl)-L-amino acid <=> alpha-L-amino acid + 5-oxo-L-proline |
| Comment(s) |
|---|
- The enzyme, found in animals and plants, acts on derivatives of
L-glutamate, L-2-aminobutanoate, L-alanine and glycine.
- The enzyme acts as a cyclotransferase, cleaving the amide bond via
transamidation using the alpha-amine of the L-glutamyl residue,
releasing it as the cyclic 5-oxo-L-proline.
- Formerly EC 2.3.2.4.
|
| Cross-references |
|---|
| BRENDA | 4.3.2.9 |
| EC2PDB | 4.3.2.9 |
| ExplorEnz | 4.3.2.9 |
| PRIAM enzyme-specific profiles | 4.3.2.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.3.2.9 |
| IUBMB Enzyme Nomenclature | 4.3.2.9 |
| IntEnz | 4.3.2.9 |
| MEDLINE | Find literature relating to 4.3.2.9 |
| MetaCyc | 4.3.2.9 |
| UniProtKB/Swiss-Prot |
| Q2UPC2, ACLK_ASPOR; | Q8GY54, GCT21_ARATH; | Q84MC1, GCT22_ARATH; |
| Q84QC1, GCT23_ARATH; | Q32LE4, GGCT_BOVIN; | O75223, GGCT_HUMAN; |
| Q9D7X8, GGCT_MOUSE; | E9R9Y3, GLIK_ASPFU; | M1W855, TCPK_CLAP2; |
| A0A1U9YI11, VERK_CLORO; |
|
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UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
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