Expasy logo

ENZYME

ENZYME entry: EC 4.3.2.9

PURL: https://purl.expasy.org/enzyme/EC/4.3.2.9
Accepted Name
gamma-glutamylcyclotransferase
Alternative Name(s)
GGCT
Reaction catalysed
an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid
Comment(s)
  • The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine.
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
  • Formerly EC 2.3.2.4.
Cross-references
BRENDA4.3.2.9
EC2PDB4.3.2.9
ExplorEnz4.3.2.9
KEGG Ligand Database for Enzyme Nomenclature4.3.2.9
IUBMB Enzyme Nomenclature4.3.2.9
MEDLINEFind literature relating to 4.3.2.9
MetaCyc4.3.2.9
Rhea expert-curated reactions4.3.2.9
UniProtKB/Swiss-Prot
Q2UPC2, ACLK_ASPORA0A0M8N9Q3, ETPK_ESCWEQ8GY54, GCT21_ARATH
Q84MC1, GCT22_ARATHQ32LE4, GGCT_BOVINO75223, GGCT_HUMAN
Q9D7X8, GGCT_MOUSEE9R9Y3, GLIK_ASPFUM1W855, TCPK_CLAP2
A0A1U9YI11, VERK_CLORO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-