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ENZYME

ENZYME entry: EC 4.3.2.9

Accepted Name
gamma-glutamylcyclotransferase
Alternative Name(s)
GGCT
Reaction catalysed
an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid
Comment(s)
  • The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine.
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
  • Formerly EC 2.3.2.4.
Cross-references
BRENDA4.3.2.9
EC2PDB4.3.2.9
ExplorEnz4.3.2.9
PRIAM enzyme-specific profiles4.3.2.9
KEGG Ligand Database for Enzyme Nomenclature4.3.2.9
IUBMB Enzyme Nomenclature4.3.2.9
IntEnz4.3.2.9
MEDLINEFind literature relating to 4.3.2.9
MetaCyc4.3.2.9
Rhea expert-curated reactions4.3.2.9
UniProtKB/Swiss-Prot
Q2UPC2, ACLK_ASPORQ8GY54, GCT21_ARATHQ84MC1, GCT22_ARATH
Q32LE4, GGCT_BOVINO75223, GGCT_HUMANQ9D7X8, GGCT_MOUSE
E9R9Y3, GLIK_ASPFUM1W855, TCPK_CLAP2A0A1U9YI11, VERK_CLORO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-