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ENZYME

ENZYME entry: EC 4.3.3.8

Accepted Name
mimosinase
Alternative Name(s)
mimosine amidohydrolase
Reaction catalysed
H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • The enzyme degrades the toxic amino acid L-mimosine.
  • It cleaves a carbon-nitrogen bond, releasing 3-hydroxy-4H-pyrid-4-one and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • It is thought to have evolved from EC 4.4.1.13.
  • It has been described in both mimosine-producing plants and some bacteria.
  • Formerly EC 3.5.1.61.
Cross-references
BRENDA4.3.3.8
EC2PDB4.3.3.8
ExplorEnz4.3.3.8
PRIAM enzyme-specific profiles4.3.3.8
KEGG Ligand Database for Enzyme Nomenclature4.3.3.8
IUBMB Enzyme Nomenclature4.3.3.8
IntEnz4.3.3.8
MEDLINEFind literature relating to 4.3.3.8
MetaCyc4.3.3.8
Rhea expert-curated reactions4.3.3.8
UniProtKB/Swiss-Prot
A8CEI3, MIMOS_LEULEU6BYK3, MIMOS_MIMPU

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