A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.3.99.3
| Accepted Name |
|---|
| 7-carboxy-7-deazaguanine synthase.
|
| Alternative Name(s) |
|---|
| 7-carboxy-7-carbaguanine synthase. |
| Reaction catalysed |
|---|
| 6-carboxy-5,6,7,8-tetrahydropterin <=> 7-carboxy-7-carbaguanine + NH(3) |
| Cofactor(s) |
|---|
| Iron-sulfur; Mg(2+); S-adenosyl-L-methionine.
|
| Comment(s) |
|---|
- The enzyme is a member of the superfamily of S-adenosyl-L-methionine-
dependent radical (radical AdoMet) enzymes.
- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an
exchangeable S-adenosyl-L-methionine molecule.
- The S-adenosyl-L-methionine is catalytic as it is regenerated at the
end of the reaction.
- The reaction is part of the biosynthesis pathway of queuosine.
|
| Cross-references |
|---|
| BRENDA | 4.3.99.3 |
| EC2PDB | 4.3.99.3 |
| ExplorEnz | 4.3.99.3 |
| PRIAM enzyme-specific profiles | 4.3.99.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.3.99.3 |
| IUBMB Enzyme Nomenclature | 4.3.99.3 |
| IntEnz | 4.3.99.3 |
| MEDLINE | Find literature relating to 4.3.99.3 |
| MetaCyc | 4.3.99.3 |
| UniProtKB/Swiss-Prot |
| A9CF16, QUEE_AGRFC; | O67826, QUEE_AQUAE; | O29808, QUEE_ARCFU; |
| Q81G67, QUEE_BACCR; | O31677, QUEE_BACSU; | Q89ZC3, QUEE_BACTN; |
| Q7VVJ8, QUEE_BORPE; | Q89SC0, QUEE_BRADU; | Q8K9D9, QUEE_BUCAP; |
| A0A0H3KB22, QUEE_BURM1; | Q0PBX7, QUEE_CAMJE; | Q9A3P3, QUEE_CAUVC; |
| Q8KFK8, QUEE_CHLTE; | Q97D55, QUEE_CLOAB; | Q728E5, QUEE_DESVH; |
| P64555, QUEE_ECO57; | P64554, QUEE_ECOLI; | A6H1N2, QUEE_FLAPJ; |
| Q74CF3, QUEE_GEOSL; | Q7NCE3, QUEE_GLOVI; | P45097, QUEE_HAEIN; |
| B0R9W6, QUEE_HALS3; | A2BJ90, QUEE_HYPBU; | Q1IHK7, QUEE_KORVE; |
| Q8EZ24, QUEE_LEPIN; | Q8TIF5, QUEE_METAC; | Q2FS67, QUEE_METHJ; |
| Q59039, QUEE_METJA; | Q8TX58, QUEE_METKA; | O27295, QUEE_METTH; |
| Q9K0Q5, QUEE_NEIMB; | Q7V9H9, QUEE_PROMA; | Q8ZZZ0, QUEE_PYRAE; |
| Q7UVG8, QUEE_RHOBA; | Q2RSY6, QUEE_RHORT; | Q9ZCV2, QUEE_RICPR; |
| P64556, QUEE_SHIFL; | P73667, QUEE_SYNY3; | Q9HII0, QUEE_THEAC; |
| Q5JGE6, QUEE_THEKO; |
|
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