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ENZYME

ENZYME entry: EC 4.3.99.3

PURL: https://purl.expasy.org/enzyme/EC/4.3.99.3
Accepted Name
7-carboxy-7-deazaguanine synthase
Alternative Name(s)
7-carboxy-7-carbaguanine synthase
Reaction catalysed
6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)
Comment(s)
  • The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes.
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction.
  • The reaction is part of the biosynthesis pathway of queuosine.
Cross-references
BRENDA4.3.99.3
EC2PDB4.3.99.3
ExplorEnz4.3.99.3
KEGG Ligand Database for Enzyme Nomenclature4.3.99.3
IUBMB Enzyme Nomenclature4.3.99.3
MEDLINEFind literature relating to 4.3.99.3
MetaCyc4.3.99.3
Rhea expert-curated reactions4.3.99.3
UniProtKB/Swiss-Prot
A9CF16, QUEE_AGRFCO67826, QUEE_AQUAEO29808, QUEE_ARCFU
Q81G67, QUEE_BACCRO31677, QUEE_BACSUQ89ZC3, QUEE_BACTN
Q7VVJ8, QUEE_BORPEQ89SC0, QUEE_BRADUQ8K9D9, QUEE_BUCAP
A0A0H3KB22, QUEE_BURM1Q0PBX7, QUEE_CAMJEQ9A3P3, QUEE_CAUVC
Q8KFK8, QUEE_CHLTEQ97D55, QUEE_CLOABP64555, QUEE_ECO57
P64554, QUEE_ECOLIA6H1N2, QUEE_FLAPJQ74CF3, QUEE_GEOSL
Q7NCE3, QUEE_GLOVIP45097, QUEE_HAEINB0R9W6, QUEE_HALS3
A2BJ90, QUEE_HYPBUQ1IHK7, QUEE_KORVEQ8EZ24, QUEE_LEPIN
Q8TIF5, QUEE_METACQ2FS67, QUEE_METHJQ59039, QUEE_METJA
Q8TX58, QUEE_METKAO27295, QUEE_METTHQ9K0Q5, QUEE_NEIMB
Q728E5, QUEE_NITV2Q7V9H9, QUEE_PROMAQ8ZZZ0, QUEE_PYRAE
Q7UVG8, QUEE_RHOBAQ2RSY6, QUEE_RHORTQ9ZCV2, QUEE_RICPR
P64556, QUEE_SHIFLP73667, QUEE_SYNY3Q9HII0, QUEE_THEAC
Q5JGE6, QUEE_THEKO

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