ENZYME entry: EC 4.4.1.1
Accepted Name |
cystathionine gamma-lyase.
|
Alternative Name(s) |
cystathionase. |
cystathioninase. |
cysteine desulfhydrase. |
cystine desulfhydrase. |
gamma-cystathionase. |
homoserine deaminase. |
homoserine dehydratase. |
Reaction catalysed |
H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+) |
Comment(s) |
- The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an
unstable enamine product that tautomerizes to an imine form, which
undergoes a hydrolytic deamination to form 2-oxobutanoate and
ammonia.
- The latter reaction, which can occur spontaneously, can also be
catalyzed by EC 3.5.99.10.
- Also catalyzes the conversion of L-homoserine to 2-oxobutanoate and
ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of
L-cysteine to pyruvate, hydrogen sulfide and ammonia.
- Formerly EC 4.2.1.15.
|
Cross-references |
BRENDA | 4.4.1.1 |
EC2PDB | 4.4.1.1 |
ExplorEnz | 4.4.1.1 |
PRIAM enzyme-specific profiles | 4.4.1.1 |
KEGG Ligand Database for Enzyme Nomenclature | 4.4.1.1 |
IUBMB Enzyme Nomenclature | 4.4.1.1 |
IntEnz | 4.4.1.1 |
MEDLINE | Find literature relating to 4.4.1.1 |
MetaCyc | 4.4.1.1 |
Rhea expert-curated reactions | 4.4.1.1 |
UniProtKB/Swiss-Prot |
A5U908, CDS1_MYCTA; | O69652, CDS1_MYCTU; | P55216, CGL2_CAEEL; |
F4K5T2, CGL_ARATH; | Q58DW2, CGL_BOVIN; | Q55DV9, CGL_DICDI; |
P32929, CGL_HUMAN; | Q60HG7, CGL_MACFA; | Q8VCN5, CGL_MOUSE; |
Q19QT7, CGL_PIG; | P18757, CGL_RAT; | P31373, CYS3_YEAST; |
Q59829, CYSA_STRCO; | O05394, MCCB_BACSU; |
|
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