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ENZYME

ENZYME entry: EC 4.4.1.11

Accepted Name
methionine gamma-lyase
Alternative Name(s)
L-methioninase
methionine lyase
Reaction catalysed
H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)
Comment(s)
  • The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • The enzyme is involved in L-methionine catabolism.
Cross-references
BRENDA4.4.1.11
EC2PDB4.4.1.11
ExplorEnz4.4.1.11
PRIAM enzyme-specific profiles4.4.1.11
KEGG Ligand Database for Enzyme Nomenclature4.4.1.11
IUBMB Enzyme Nomenclature4.4.1.11
IntEnz4.4.1.11
MEDLINEFind literature relating to 4.4.1.11
MetaCyc4.4.1.11
Rhea expert-curated reactions4.4.1.11
UniProtKB/Swiss-Prot
Q8RDT4, MEGL_FUSNNQ8L0X4, MEGL_FUSNPQ7MX71, MEGL_PORGI
A0A0J6G7P5, MEGL_PSEDMP13254, MEGL_PSEPUQ826W3, MEGL_STRAW
Q73KL7, MEGL_TREDEQ9SGU9, MGL_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
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