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ENZYME

ENZYME entry: EC 4.4.1.28

PURL: https://purl.expasy.org/enzyme/EC/4.4.1.28
Accepted Name
L-cysteine desulfidase
Alternative Name(s)
L-cysteine desulfhydrase
Reaction catalysed
L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)
Comment(s)
  • The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1).
  • It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The same reaction can also be catalyzed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1).
Cross-references
BRENDA4.4.1.28
EC2PDB4.4.1.28
ExplorEnz4.4.1.28
KEGG Ligand Database for Enzyme Nomenclature4.4.1.28
IUBMB Enzyme Nomenclature4.4.1.28
MEDLINEFind literature relating to 4.4.1.28
MetaCyc4.4.1.28
Rhea expert-curated reactions4.4.1.28
UniProtKB/Swiss-Prot
Q58431, CYDE_METJAA4FW56, CYDE_METM5A9A9J5, CYDE_METM6
A6VH54, CYDE_METM7Q6LX84, CYDE_METMPQ9M1R1, LCYD1_ARATH
Q9LGZ2, LCYD1_ORYSJQ5JNT6, LCYD2_ORYSJQ8RDT4, MEGL_FUSNN
P06721, METC_ECOLI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-