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ENZYME entry: EC 4.4.1.34

Accepted Name
Isoprene-epoxide--glutathione S-transferase.
Reaction catalysed
2-(glutathione-S-yl)-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
Comment(s)
  • The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation.
  • The enzyme can catalyze the glutathione-dependent ring opening of various epoxides, but the highest activity is with (3R)-3,4-epoxy-3- methylbut-1-ene, which is derived from isoprene by EC 1.14.13.69.
Cross-references
BRENDA4.4.1.34
EC2PDB4.4.1.34
ExplorEnz4.4.1.34
PRIAM enzyme-specific profiles4.4.1.34
KEGG Ligand Database for Enzyme Nomenclature4.4.1.34
IUBMB Enzyme Nomenclature4.4.1.34
IntEnz4.4.1.34
MEDLINEFind literature relating to 4.4.1.34
MetaCyc4.4.1.34
Rhea expert-curated reactions4.4.1.34
UniProtKB/Swiss-Prot
Q9RBP4, ISOI_RHOSX

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