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ENZYME entry: EC 4.4.1.35

Accepted Name
L-cystine beta-lyase.
Reaction catalysed
L-cystine + H(2)O <=> L-thiocysteine + pyruvate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine.
Cross-references
BRENDA4.4.1.35
EC2PDB4.4.1.35
ExplorEnz4.4.1.35
PRIAM enzyme-specific profiles4.4.1.35
KEGG Ligand Database for Enzyme Nomenclature4.4.1.35
IUBMB Enzyme Nomenclature4.4.1.35
IntEnz4.4.1.35
MEDLINEFind literature relating to 4.4.1.35
MetaCyc4.4.1.35
UniProtKB/Swiss-Prot
Q9SUR6, CORI3_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
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