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ENZYME entry: EC

Accepted Name
S-adenosyl-L-methionine lyase
Alternative Name(s)
adenosylmethionine cyclotransferase
S-adenosyl-L-methionine alkyltransferase (cyclizing)
SAM lyase
Reaction catalysed
S-adenosyl-L-methionine <=> L-homoserine lactone + S-methyl-5'-thioadenosine
  • The enzyme was originally described from the yeast Saccharomyces cerevisiae (as EC, though it had not been well characterized.
  • It was also incorrectly described from several bacteriophages as a hydrolase (EC
  • Later work has shown the bacteriophage enzyme to be a lyase.
  • The enzyme binds its substrate at the border between two subunits of a trimeric complex in a position that prevents it from interacting with water.
  • Instead, the substrate reacts with itself and splits in two. The product, L-homoserine lactone, spontaneously hydrolyzes to L-homoserine.
  • Formerly EC and EC
PRIAM enzyme-specific profiles4.4.1.42
KEGG Ligand Database for Enzyme Nomenclature4.4.1.42
IUBMB Enzyme Nomenclature4.4.1.42
MEDLINEFind literature relating to
Rhea expert-curated reactions4.4.1.42
P07693, ADOM_BPT3

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