- A widely distributed family of related enzymes found in protozoans,
plants, bacteria, animals and viruses that cleave ssRNA 3'-phosphate
group with little base specificity.
- The enzyme catalyzes a two-stage endonucleolytic cleavage.
- The first reaction produces 5'-hydroxy-phosphooligonucletides and
3'-phosphooligonucleotides ending with a 2',3'-cyclic phosphodiester,
which are released from the enzyme.
- The enzyme then hydrolyzes the cyclic products in a second reaction
that takes place only when all the susceptible 3',5'-phosphodiester
bonds have been cyclised.
- The second reaction is a reversal of the first reaction using the
hydroxyl group of water instead of the 5'-hydroxyl group of ribose.
- The overall process is that of a phosphorus-oxygen lyase followed by
hydrolysis to form the 3'-nucleotides.
- Formerly EC 2.7.7.17, EC 3.1.4.23 and EC 3.1.27.1.
|
| UniProtKB/Swiss-Prot |
| Q7M438, RNDI_DICDI; | P81296, RNL2_LENED; | P80022, RNLE_SOLLC; |
| P80196, RNLX_SOLLC; | P23540, RNMC1_MOMCH; | P19791, RNM_ASPPH; |
| P08056, RNRH_RHINI; | Q7SID5, RNS11_NICAL; | P42813, RNS1_ARATH; |
| O80322, RNS1_PYRPY; | Q38716, RNS2_ANTHI; | P42814, RNS2_ARATH; |
| P04007, RNS2_NICAL; | Q40965, RNS2_PYRPY; | Q01796, RNS2_SOLTU; |
| P42815, RNS3_ARATH; | Q40875, RNS3_PETHY; | O80323, RNS3_PYRPY; |
| Q38717, RNS4_ANTHI; | Q40966, RNS4_PYRPY; | P93460, RNS5_PYRPY; |
| Q40379, RNS6_NICAL; | O80324, RNS6_PYRPY; | Q40381, RNS7_NICAL; |
| O80325, RNS7_PYRPY; | O61887, RNST2_CAEEL; | C0HKG5, RNT2A_MOUSE; |
| C0HKG6, RNT2B_MOUSE; | P10281, RNT2_ASPOR; | B8XY56, RNT2_DANRE; |
| O00584, RNT2_HUMAN; | Q7M329, RNT2_PIG; | P24657, RNTR_HYPRU; |
| Q5AK94, RNY1A_CANAL; | Q5AKB1, RNY1B_CANAL; | Q75BW5, RNY1_ASHGO; |
| Q4WXZ5, RNY1_ASPFU; | Q6FP42, RNY1_CANGA; | Q6BHB1, RNY1_DEBHA; |
| Q5B3K6, RNY1_EMENI; | Q6CRT6, RNY1_KLULA; | Q6CAV7, RNY1_YARLI; |
| Q02933, RNY1_YEAST; |
|