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ENZYME entry: EC 4.8.1.1

Accepted Name
L-piperazate synthase.
Reaction catalysed
N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O
Comment(s)
  • Contains a heme b cofactor.
  • The enzyme, characterized from the bacterium Kutzneria sp. 744, is one of very few enzymes known to result in the formation of an N-N bond.
  • (3S)-1,2-diazinane-3-carboxylate (piperazate) is known to be incorporated into assorted secondary products that are produced by nonribosomal peptide synthetase or nonribosomal peptide synthetase/polyketide synthase hybrid pathways, such as the kutznerides, padanamides, himastatins, and sanglifehrins.
Cross-references
BRENDA4.8.1.1
EC2PDB4.8.1.1
ExplorEnz4.8.1.1
PRIAM enzyme-specific profiles4.8.1.1
KEGG Ligand Database for Enzyme Nomenclature4.8.1.1
IUBMB Enzyme Nomenclature4.8.1.1
IntEnz4.8.1.1
MEDLINEFind literature relating to 4.8.1.1
MetaCyc4.8.1.1
Rhea expert-curated reactions4.8.1.1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-