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ENZYME entry: EC 4.8.1.2

Accepted Name
aliphatic aldoxime dehydratase.
Alternative Name(s)
aliphatic aldoxime hydro-lyase.
Reaction catalysed
an aliphatic aldoxime <=> a nitrile + H2O
Comment(s)
  • The enzyme from Pseudomonas chlororaphis contains Ca(2+) and protoheme IX, the iron of which must be in the form iron(II) for activity.
  • The enzyme exhibits a strong preference for aliphatic aldoximes, such as butyraldoxime and acetaldoxime, over aromatic aldoximes, such as pyridine-2-aldoxime, which is a poor substrate.
  • No activity was found with the aromatic aldoximes benzaldoxime and pyridine-4-aldoxime.
  • Formerly EC 4.99.1.5.
Cross-references
BRENDA4.8.1.2
EC2PDB4.8.1.2
ExplorEnz4.8.1.2
PRIAM enzyme-specific profiles4.8.1.2
KEGG Ligand Database for Enzyme Nomenclature4.8.1.2
IUBMB Enzyme Nomenclature4.8.1.2
IntEnz4.8.1.2
MEDLINEFind literature relating to 4.8.1.2
MetaCyc4.8.1.2
Rhea expert-curated reactions4.8.1.2
UniProtKB/Swiss-Prot
Q7WSJ4, OXD_PSECL;  Q4W7T3, OXD_PSESP;  Q76K71, OXD_RHOER;  
Q76EV4, OXD_RHOGO;  

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