Expasy logo

ENZYME

ENZYME entry: EC 4.98.1.1

Accepted Name
protoporphyrin ferrochelatase
Alternative Name(s)
ferrochelatase
ferro-protoporphyrin chelatase
heme synthase
iron chelatase
protoheme ferro-lyase
Reaction catalysed
2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX
Comment(s)
  • The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.
  • The reaction is catalyzed only in the reverse direction.
  • Formerly EC 4.99.1.1.
Cross-references
BRENDA4.98.1.1
EC2PDB4.98.1.1
ExplorEnz4.98.1.1
PRIAM enzyme-specific profiles4.98.1.1
KEGG Ligand Database for Enzyme Nomenclature4.98.1.1
IUBMB Enzyme Nomenclature4.98.1.1
IntEnz4.98.1.1
MEDLINEFind literature relating to 4.98.1.1
MetaCyc4.98.1.1
Rhea expert-curated reactions4.98.1.1
UniProtKB/Swiss-Prot
P39597, EFEB_BACSUQ8XAS4, EFEB_ECO57A1A9S3, EFEB_ECOK1
Q0TJ48, EFEB_ECOL5Q8CW71, EFEB_ECOL6P31545, EFEB_ECOLI
Q1RDJ8, EFEB_ECOUTQ31Z86, EFEB_SHIBSQ0T616, EFEB_SHIF8
Q83LK4, EFEB_SHIFLQ3Z396, EFEB_SHISSQ7CI09, EFEB_YERPE
Q1CHD5, EFEB_YERPNQ66BP4, EFEB_YERPSP42043, HEMH1_ARATH
Q69TB1, HEMH1_ORYSJQ8EFF4, HEMH1_SHEONO04921, HEMH2_ARATH
Q0DIV0, HEMH2_ORYSJQ8EBZ7, HEMH2_SHEONQ6F7N0, HEMH_ACIAD
B7H0X1, HEMH_ACIB3B7I4A8, HEMH_ACIB5B2I2R9, HEMH_ACIBC
B0VLE0, HEMH_ACIBSA3M1P7, HEMH_ACIBTB0VEC9, HEMH_ACIBY
C1F1C7, HEMH_ACIC5A3N3M9, HEMH_ACTP2B3H307, HEMH_ACTP7
B0BTL7, HEMH_ACTPJA0KL51, HEMH_AERHHQ8U9F7, HEMH_AGRFC
Q0VSV6, HEMH_ALCBSQ5E6Q7, HEMH_ALIF1B5FBZ6, HEMH_ALIFM
B6EHK1, HEMH_ALISLB9JS40, HEMH_ALLAMO67083, HEMH_AQUAE
Q5P1H1, HEMH_AROAEA1K8P4, HEMH_AZOSBC1DEU1, HEMH_AZOVD
Q6MHT3, HEMH_BDEBAQ7WGI0, HEMH_BORBRQ7W515, HEMH_BORPA
Q7VVX8, HEMH_BORPEP22600, HEMH_BOVINP28602, HEMH_BRADU
A5EBP8, HEMH_BRASBB2SCP3, HEMH_BRUA1Q2YIS9, HEMH_BRUA2
A6X6W2, HEMH_BRUA4P0A3D8, HEMH_BRUABA9MDJ3, HEMH_BRUC2
C0RK28, HEMH_BRUMBP0A3D6, HEMH_BRUMEA5VTJ7, HEMH_BRUO2
A9WXE2, HEMH_BRUSIP0A3D7, HEMH_BRUSUB1YTJ5, HEMH_BURA4
A0K4S2, HEMH_BURCHQ0BI24, HEMH_BURCMQ39JD2, HEMH_BURL3
A3MNA4, HEMH_BURM7A2S570, HEMH_BURM9Q62HD1, HEMH_BURMA
A1V0U1, HEMH_BURMSB1JW14, HEMH_BURO0Q1BYX9, HEMH_BURO1
A3NYY2, HEMH_BURP0Q3JP06, HEMH_BURP1A3ND73, HEMH_BURP6
Q63R43, HEMH_BURPSQ2SYZ9, HEMH_BURTAA4JBR6, HEMH_BURVG
A7ZE60, HEMH_CAMC1A0RNU4, HEMH_CAMFFA8FKS9, HEMH_CAMJ8
A7H4N6, HEMH_CAMJDQ9PI08, HEMH_CAMJEA1VYL5, HEMH_CAMJJ
Q5HVR0, HEMH_CAMJRP57777, HEMH_CAUVCB8GW40, HEMH_CAUVN
Q11ES4, HEMH_CHESBO42479, HEMH_CHICKQ5L6X6, HEMH_CHLAB
Q824K8, HEMH_CHLCVQ252Z7, HEMH_CHLFFQ9PJQ6, HEMH_CHLMU
Q9Z7V1, HEMH_CHLPNB0B858, HEMH_CHLT2Q3KLL2, HEMH_CHLTA
B0BCC3, HEMH_CHLTBO84492, HEMH_CHLTRQ7NV65, HEMH_CHRVO
B5EJ44, HEMH_CITBBB6J5R6, HEMH_COXB1B6J386, HEMH_COXB2
A9KGX9, HEMH_COXBNQ83FA4, HEMH_COXBUA7MNM8, HEMH_CROS8
P42044, HEMH_CUCSAQ1LPN9, HEMH_CUPMCQ0KCJ6, HEMH_CUPNH
Q473L7, HEMH_CUPPJB3R447, HEMH_CUPTRB8HK77, HEMH_CYAP4
Q47HJ6, HEMH_DECARQ9RV98, HEMH_DEIRAQ6APB0, HEMH_DESPS
Q54IA8, HEMH_DICDIQ9V9S8, HEMH_DROMEA7ZIN5, HEMH_ECO24
B7UKF5, HEMH_ECO27B7MDZ7, HEMH_ECO45B7L7A0, HEMH_ECO55
Q8XD39, HEMH_ECO57B5Z3Y6, HEMH_ECO5EB7NIF5, HEMH_ECO7I
B7MQJ0, HEMH_ECO81B7M3W7, HEMH_ECO8AC4ZUS9, HEMH_ECOBW
B1XFR2, HEMH_ECODHA7ZXD3, HEMH_ECOHSA1A8E1, HEMH_ECOK1
Q0TKG6, HEMH_ECOL5Q8FK83, HEMH_ECOL6B1IZB9, HEMH_ECOLC
P23871, HEMH_ECOLIB7N928, HEMH_ECOLUB6I0C7, HEMH_ECOSE
B1LJN3, HEMH_ECOSMQ1RF60, HEMH_ECOUTC5BD17, HEMH_EDWI9
A4W7F9, HEMH_ENT38B2VHX1, HEMH_ERWT9B7LV14, HEMH_ESCF3
Q14H85, HEMH_FRAT1A7NBJ3, HEMH_FRATFQ2A406, HEMH_FRATH
B2SDE2, HEMH_FRATMA0Q6Z1, HEMH_FRATNQ0BME1, HEMH_FRATO
Q5NFT3, HEMH_FRATTA4IYH5, HEMH_FRATWB9M326, HEMH_GEODF
Q39ZQ5, HEMH_GEOMGQ747F5, HEMH_GEOSLC6E7U2, HEMH_GEOSM
A5GDG7, HEMH_GEOURB7KGB9, HEMH_GLOC7Q7NMC7, HEMH_GLOVI
Q5FSJ9, HEMH_GLUOXQ4QLD6, HEMH_HAEI8A5UCU6, HEMH_HAEIE
P43868, HEMH_HAEINC4K332, HEMH_HAMD5Q17YG0, HEMH_HELAH
Q7VHH1, HEMH_HELHPB6JMR9, HEMH_HELP2B5Z875, HEMH_HELPG
Q1CSI9, HEMH_HELPHQ9ZKD4, HEMH_HELPJB2UUI4, HEMH_HELPS
P56107, HEMH_HELPYA9B546, HEMH_HERA2A4G8D5, HEMH_HERAR
P42045, HEMH_HORVUP22830, HEMH_HUMANQ31EG9, HEMH_HYDCU
Q0BWA5, HEMH_HYPNAQ5QVZ8, HEMH_IDILOA6T228, HEMH_JANMA
B5Y0N2, HEMH_KLEP3Q5X7W3, HEMH_LEGPAA5IHG9, HEMH_LEGPC
Q5ZYE7, HEMH_LEGPHQ5WZB4, HEMH_LEGPLB0SF60, HEMH_LEPBA
Q8GCV0, HEMH_LEPBIQ04NU7, HEMH_LEPBJQ04X34, HEMH_LEPBL
B0SNJ9, HEMH_LEPBPQ65SV7, HEMH_MANSMA6VXF8, HEMH_MARMS
A1U0R2, HEMH_MARN8Q607T4, HEMH_METCAQ1H397, HEMH_METFK
A2SIR1, HEMH_METPPB8EJ84, HEMH_METSBB0JRN7, HEMH_MICAN
P22315, HEMH_MOUSEQ5F9U6, HEMH_NEIG1Q9JVA5, HEMH_NEIMA
Q9K097, HEMH_NEIMBA1KSY0, HEMH_NEIMFQ82UK8, HEMH_NITEU
Q1QI02, HEMH_NITHXQ3JAW7, HEMH_NITOCA6Q2Y9, HEMH_NITSB
B2J9P0, HEMH_NOSP7Q8YQR8, HEMH_NOSS1B1ZSW3, HEMH_OPITP
A2Y3Q5, HEMH_ORYSIQ3YA36, HEMH_PANTRQ7U5G0, HEMH_PARMW
B2JGE7, HEMH_PARP8B2SXB8, HEMH_PARPJQ6MAW8, HEMH_PARUW
Q145F5, HEMH_PARXLP57874, HEMH_PASMUQ6D7Z4, HEMH_PECAS
A1ASJ7, HEMH_PELPDQ4FNS1, HEMH_PELUBB4RD10, HEMH_PHEZH
Q7N0P6, HEMH_PHOLLQ6LTE0, HEMH_PHOPRQ12BZ9, HEMH_POLSJ
B2RHB4, HEMH_PORG3Q7MXP4, HEMH_PORGIA3PBP9, HEMH_PROM0
A2C0Y4, HEMH_PROM1A8G3P0, HEMH_PROM2A2C7Q7, HEMH_PROM3
A9BEE9, HEMH_PROM4A2BVI7, HEMH_PROM5Q31C09, HEMH_PROM9
Q7VD58, HEMH_PROMAB4F1Q1, HEMH_PROMHQ7V6C6, HEMH_PROMM
Q7V2F5, HEMH_PROMPA2BQ06, HEMH_PROMSQ46GQ1, HEMH_PROMT
Q48MT5, HEMH_PSE14Q15NQ1, HEMH_PSEA6A6VC51, HEMH_PSEA7
B7V0K1, HEMH_PSEA8Q02G19, HEMH_PSEABQ9HVD7, HEMH_PSEAE
Q1IEW1, HEMH_PSEE4Q4K6B3, HEMH_PSEF5P57778, HEMH_PSEFC
C3KDN7, HEMH_PSEFSA4XR78, HEMH_PSEMYA5VYH6, HEMH_PSEP1
Q3K6Y7, HEMH_PSEPFB0KNF5, HEMH_PSEPGQ88PV4, HEMH_PSEPK
B1JER5, HEMH_PSEPWQ888A2, HEMH_PSESMQ4ZXU9, HEMH_PSEU2
Q4FUR3, HEMH_PSYA2Q1QDQ5, HEMH_PSYCKA5WH56, HEMH_PSYWF
Q8XW32, HEMH_RALN1B2UBQ0, HEMH_RALPJB3PZU8, HEMH_RHIE6
Q2K4C4, HEMH_RHIECQ1MBW8, HEMH_RHIL3Q98H61, HEMH_RHILO
B5ZPG3, HEMH_RHILWQ92M52, HEMH_RHIMEQ7UFZ7, HEMH_RHOBA
Q59735, HEMH_RHOCAQ2IRD5, HEMH_RHOP2Q07H58, HEMH_RHOP5
Q6NBF3, HEMH_RHOPAQ13CU0, HEMH_RHOPSB3QF66, HEMH_RHOPT
A8GYD7, HEMH_RICB8Q1RGK5, HEMH_RICBRA8F0B2, HEMH_RICCK
Q92FV4, HEMH_RICCNQ4UJN9, HEMH_RICFEQ9ZC84, HEMH_RICPR
Q68VM9, HEMH_RICTYB7K399, HEMH_RIPO1B5EXN2, HEMH_SALA4
A9MLY4, HEMH_SALARQ57S74, HEMH_SALCHB5FLJ9, HEMH_SALDC
B5QU78, HEMH_SALEPB5R613, HEMH_SALG2B4T9I3, HEMH_SALHS
B4SWY3, HEMH_SALNSQ5PFJ1, HEMH_SALPAA9MW82, HEMH_SALPB
C0PVE1, HEMH_SALPCB5BD43, HEMH_SALPKB4TMG7, HEMH_SALSV
Q8Z8T2, HEMH_SALTIP37408, HEMH_SALTYO59786, HEMH_SCHPO
A8GAV7, HEMH_SERP5Q12KR9, HEMH_SHEDOB2U4S8, HEMH_SHIB3
Q325C1, HEMH_SHIBSQ32J55, HEMH_SHIDSQ0T7B0, HEMH_SHIF8
Q83SE5, HEMH_SHIFLQ3Z4S4, HEMH_SHISSQ2NV56, HEMH_SODGM
B4SNS0, HEMH_STRM5A4VKZ1, HEMH_STUS1Q30S35, HEMH_SULDN
B2V955, HEMH_SULSYQ31S00, HEMH_SYNE7Q2JVK5, HEMH_SYNJA
Q2JHZ4, HEMH_SYNJBB1XL79, HEMH_SYNP2Q5N2B2, HEMH_SYNP6
A5GJF5, HEMH_SYNPWA5GS98, HEMH_SYNR3Q0I8L9, HEMH_SYNS3
Q3ALP2, HEMH_SYNSCP54225, HEMH_SYNY3C5BIF4, HEMH_TERTT
Q9HLB8, HEMH_THEACQ72L32, HEMH_THET2Q8DGU6, HEMH_THEVB
Q978U9, HEMH_THEVOQ3SHA3, HEMH_THIDAB8GU82, HEMH_THISH
Q10WR6, HEMH_TRIEIQ3MCT9, HEMH_TRIV2B7VII4, HEMH_VIBA3
Q9KTB6, HEMH_VIBCHQ87RH3, HEMH_VIBPAQ8DFM2, HEMH_VIBVU
Q7MMR4, HEMH_VIBVYQ8D226, HEMH_WIGBRQ73FY6, HEMH_WOLPM
B3CLU1, HEMH_WOLPPQ7M7P9, HEMH_WOLSUQ5GRR7, HEMH_WOLTR
C0R4L0, HEMH_WOLWRQ8PEX0, HEMH_XANACQ8P3H6, HEMH_XANCP
O57478, HEMH_XENLAB2I7H7, HEMH_XYLF2Q9PFU1, HEMH_XYLFA
B0U456, HEMH_XYLFMQ87B82, HEMH_XYLFTP16622, HEMH_YEAST
A1JNA4, HEMH_YERE8P43413, HEMH_YERENA7FL85, HEMH_YERP3
Q1C4Q0, HEMH_YERPAB2K6Z7, HEMH_YERPBQ8ZC98, HEMH_YERPE
A9R0Q8, HEMH_YERPGQ1CL26, HEMH_YERPNA4TPA3, HEMH_YERPP
Q05338, HEMH_YERPSB1JHN0, HEMH_YERPYP57779, HEMH_ZYMMO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.98.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.98.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-