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ENZYME entry: EC 4.99.1.1

Accepted Name
Protoporphyrin ferrochelatase.
Alternative Name(s)
Ferrochelatase.
Heme synthase.
Iron chelatase.
Protoheme ferro-lyase.
Reaction catalysed
Protoheme + 2 H(+) <=> protoporphyrin + Fe(2+)
Comment(s)
The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.
Cross-references
PROSITEPDOC00462
BRENDA4.99.1.1
EC2PDB4.99.1.1
ExplorEnz4.99.1.1
PRIAM enzyme-specific profiles4.99.1.1
KEGG Ligand Database for Enzyme Nomenclature4.99.1.1
IUBMB Enzyme Nomenclature4.99.1.1
IntEnz4.99.1.1
MEDLINEFind literature relating to 4.99.1.1
MetaCyc4.99.1.1
Rhea expert-curated reactions4.99.1.1
UniProtKB/Swiss-Prot
P42043, HEMH1_ARATH;  Q69TB1, HEMH1_ORYSJ;  Q8EFF4, HEMH1_SHEON;  
O04921, HEMH2_ARATH;  Q0DIV0, HEMH2_ORYSJ;  Q8EBZ7, HEMH2_SHEON;  
Q6F7N0, HEMH_ACIAD;  B7H0X1, HEMH_ACIB3;  B7I4A8, HEMH_ACIB5;  
B2I2R9, HEMH_ACIBC;  B0VLE0, HEMH_ACIBS;  A3M1P7, HEMH_ACIBT;  
B0VEC9, HEMH_ACIBY;  C1F1C7, HEMH_ACIC5;  A3N3M9, HEMH_ACTP2;  
B3H307, HEMH_ACTP7;  B0BTL7, HEMH_ACTPJ;  A0KL51, HEMH_AERHH;  
Q8U9F7, HEMH_AGRFC;  B9JS40, HEMH_AGRVS;  Q0VSV6, HEMH_ALCBS;  
Q5E6Q7, HEMH_ALIF1;  B5FBZ6, HEMH_ALIFM;  B6EHK1, HEMH_ALISL;  
O67083, HEMH_AQUAE;  Q5P1H1, HEMH_AROAE;  A1K8P4, HEMH_AZOSB;  
C1DEU1, HEMH_AZOVD;  Q6MHT3, HEMH_BDEBA;  Q7WGI0, HEMH_BORBR;  
Q7W515, HEMH_BORPA;  Q7VVX8, HEMH_BORPE;  P22600, HEMH_BOVIN;  
P28602, HEMH_BRADU;  A5EBP8, HEMH_BRASB;  B2SCP3, HEMH_BRUA1;  
Q2YIS9, HEMH_BRUA2;  P0A3D8, HEMH_BRUAB;  A9MDJ3, HEMH_BRUC2;  
C0RK28, HEMH_BRUMB;  P0A3D6, HEMH_BRUME;  A5VTJ7, HEMH_BRUO2;  
A9WXE2, HEMH_BRUSI;  P0A3D7, HEMH_BRUSU;  B1YTJ5, HEMH_BURA4;  
Q1BYX9, HEMH_BURCA;  B1JW14, HEMH_BURCC;  A0K4S2, HEMH_BURCH;  
Q0BI24, HEMH_BURCM;  Q39JD2, HEMH_BURL3;  A3MNA4, HEMH_BURM7;  
A2S570, HEMH_BURM9;  Q62HD1, HEMH_BURMA;  A1V0U1, HEMH_BURMS;  
A3NYY2, HEMH_BURP0;  Q3JP06, HEMH_BURP1;  A3ND73, HEMH_BURP6;  
Q63R43, HEMH_BURPS;  Q2SYZ9, HEMH_BURTA;  A4JBR6, HEMH_BURVG;  
A7ZE60, HEMH_CAMC1;  A0RNU4, HEMH_CAMFF;  A8FKS9, HEMH_CAMJ8;  
A7H4N6, HEMH_CAMJD;  Q9PI08, HEMH_CAMJE;  A1VYL5, HEMH_CAMJJ;  
Q5HVR0, HEMH_CAMJR;  P57777, HEMH_CAUVC;  B8GW40, HEMH_CAUVN;  
Q11ES4, HEMH_CHESB;  O42479, HEMH_CHICK;  Q5L6X6, HEMH_CHLAB;  
Q824K8, HEMH_CHLCV;  Q252Z7, HEMH_CHLFF;  Q9PJQ6, HEMH_CHLMU;  
Q9Z7V1, HEMH_CHLPN;  B0B858, HEMH_CHLT2;  Q3KLL2, HEMH_CHLTA;  
B0BCC3, HEMH_CHLTB;  O84492, HEMH_CHLTR;  Q7NV65, HEMH_CHRVO;  
B6J5R6, HEMH_COXB1;  B6J386, HEMH_COXB2;  A9KGX9, HEMH_COXBN;  
Q83FA4, HEMH_COXBU;  A7MNM8, HEMH_CROS8;  P42044, HEMH_CUCSA;  
Q1LPN9, HEMH_CUPMC;  Q0KCJ6, HEMH_CUPNH;  Q473L7, HEMH_CUPPJ;  
B3R447, HEMH_CUPTR;  B8HK77, HEMH_CYAP4;  Q47HJ6, HEMH_DECAR;  
Q9RV98, HEMH_DEIRA;  Q6APB0, HEMH_DESPS;  Q54IA8, HEMH_DICDI;  
Q9V9S8, HEMH_DROME;  A7ZIN5, HEMH_ECO24;  B7UKF5, HEMH_ECO27;  
B7MDZ7, HEMH_ECO45;  B7L7A0, HEMH_ECO55;  Q8XD39, HEMH_ECO57;  
B5Z3Y6, HEMH_ECO5E;  B7NIF5, HEMH_ECO7I;  B7MQJ0, HEMH_ECO81;  
B7M3W7, HEMH_ECO8A;  C4ZUS9, HEMH_ECOBW;  B1XFR2, HEMH_ECODH;  
A7ZXD3, HEMH_ECOHS;  A1A8E1, HEMH_ECOK1;  Q0TKG6, HEMH_ECOL5;  
Q8FK83, HEMH_ECOL6;  B1IZB9, HEMH_ECOLC;  P23871, HEMH_ECOLI;  
B7N928, HEMH_ECOLU;  B6I0C7, HEMH_ECOSE;  B1LJN3, HEMH_ECOSM;  
Q1RF60, HEMH_ECOUT;  C5BD17, HEMH_EDWI9;  A4W7F9, HEMH_ENT38;  
B2VHX1, HEMH_ERWT9;  B7LV14, HEMH_ESCF3;  Q14H85, HEMH_FRAT1;  
A7NBJ3, HEMH_FRATF;  Q2A406, HEMH_FRATH;  B2SDE2, HEMH_FRATM;  
A0Q6Z1, HEMH_FRATN;  Q0BME1, HEMH_FRATO;  Q5NFT3, HEMH_FRATT;  
A4IYH5, HEMH_FRATW;  B5EJ44, HEMH_GEOBB;  B9M326, HEMH_GEODF;  
Q39ZQ5, HEMH_GEOMG;  Q747F5, HEMH_GEOSL;  C6E7U2, HEMH_GEOSM;  
A5GDG7, HEMH_GEOUR;  B7KGB9, HEMH_GLOC7;  Q7NMC7, HEMH_GLOVI;  
Q5FSJ9, HEMH_GLUOX;  Q4QLD6, HEMH_HAEI8;  A5UCU6, HEMH_HAEIE;  
P43868, HEMH_HAEIN;  C4K332, HEMH_HAMD5;  Q17YG0, HEMH_HELAH;  
Q7VHH1, HEMH_HELHP;  B6JMR9, HEMH_HELP2;  B5Z875, HEMH_HELPG;  
Q1CSI9, HEMH_HELPH;  Q9ZKD4, HEMH_HELPJ;  B2UUI4, HEMH_HELPS;  
P56107, HEMH_HELPY;  A9B546, HEMH_HERA2;  A4G8D5, HEMH_HERAR;  
P42045, HEMH_HORVU;  P22830, HEMH_HUMAN;  Q31EG9, HEMH_HYDCU;  
Q0BWA5, HEMH_HYPNA;  Q5QVZ8, HEMH_IDILO;  A6T228, HEMH_JANMA;  
B5Y0N2, HEMH_KLEP3;  Q5X7W3, HEMH_LEGPA;  A5IHG9, HEMH_LEGPC;  
Q5ZYE7, HEMH_LEGPH;  Q5WZB4, HEMH_LEGPL;  B0SF60, HEMH_LEPBA;  
Q8GCV0, HEMH_LEPBI;  Q04NU7, HEMH_LEPBJ;  Q04X34, HEMH_LEPBL;  
B0SNJ9, HEMH_LEPBP;  Q65SV7, HEMH_MANSM;  A1U0R2, HEMH_MARHV;  
A6VXF8, HEMH_MARMS;  Q607T4, HEMH_METCA;  Q1H397, HEMH_METFK;  
A2SIR1, HEMH_METPP;  B8EJ84, HEMH_METSB;  B0JRN7, HEMH_MICAN;  
P22315, HEMH_MOUSE;  Q5F9U6, HEMH_NEIG1;  Q9JVA5, HEMH_NEIMA;  
Q9K097, HEMH_NEIMB;  A1KSY0, HEMH_NEIMF;  Q82UK8, HEMH_NITEU;  
Q1QI02, HEMH_NITHX;  Q3JAW7, HEMH_NITOC;  A6Q2Y9, HEMH_NITSB;  
B2J9P0, HEMH_NOSP7;  Q8YQR8, HEMH_NOSS1;  A6X6W2, HEMH_OCHA4;  
B1ZSW3, HEMH_OPITP;  A2Y3Q5, HEMH_ORYSI;  Q3YA36, HEMH_PANTR;  
B2JGE7, HEMH_PARP8;  B2SXB8, HEMH_PARPJ;  Q6MAW8, HEMH_PARUW;  
Q145F5, HEMH_PARXL;  P57874, HEMH_PASMU;  Q6D7Z4, HEMH_PECAS;  
A1ASJ7, HEMH_PELPD;  Q4FNS1, HEMH_PELUB;  B4RD10, HEMH_PHEZH;  
Q7N0P6, HEMH_PHOLL;  Q6LTE0, HEMH_PHOPR;  Q12BZ9, HEMH_POLSJ;  
B2RHB4, HEMH_PORG3;  Q7MXP4, HEMH_PORGI;  A3PBP9, HEMH_PROM0;  
A2C0Y4, HEMH_PROM1;  A8G3P0, HEMH_PROM2;  A2C7Q7, HEMH_PROM3;  
A9BEE9, HEMH_PROM4;  A2BVI7, HEMH_PROM5;  Q31C09, HEMH_PROM9;  
Q7VD58, HEMH_PROMA;  B4F1Q1, HEMH_PROMH;  Q7V6C6, HEMH_PROMM;  
Q7V2F5, HEMH_PROMP;  A2BQ06, HEMH_PROMS;  Q46GQ1, HEMH_PROMT;  
Q48MT5, HEMH_PSE14;  Q15NQ1, HEMH_PSEA6;  A6VC51, HEMH_PSEA7;  
B7V0K1, HEMH_PSEA8;  Q02G19, HEMH_PSEAB;  Q9HVD7, HEMH_PSEAE;  
Q1IEW1, HEMH_PSEE4;  Q4K6B3, HEMH_PSEF5;  P57778, HEMH_PSEFC;  
C3KDN7, HEMH_PSEFS;  A4XR78, HEMH_PSEMY;  A5VYH6, HEMH_PSEP1;  
Q3K6Y7, HEMH_PSEPF;  B0KNF5, HEMH_PSEPG;  Q88PV4, HEMH_PSEPK;  
B1JER5, HEMH_PSEPW;  Q888A2, HEMH_PSESM;  Q4ZXU9, HEMH_PSEU2;  
A4VKZ1, HEMH_PSEU5;  Q4FUR3, HEMH_PSYA2;  Q1QDQ5, HEMH_PSYCK;  
A5WH56, HEMH_PSYWF;  B2UBQ0, HEMH_RALPJ;  Q8XW32, HEMH_RALSO;  
B3PZU8, HEMH_RHIE6;  Q2K4C4, HEMH_RHIEC;  Q1MBW8, HEMH_RHIL3;  
Q98H61, HEMH_RHILO;  B5ZPG3, HEMH_RHILW;  Q92M52, HEMH_RHIME;  
Q7UFZ7, HEMH_RHOBA;  Q59735, HEMH_RHOCA;  Q2IRD5, HEMH_RHOP2;  
Q07H58, HEMH_RHOP5;  Q6NBF3, HEMH_RHOPA;  Q13CU0, HEMH_RHOPS;  
B3QF66, HEMH_RHOPT;  A8GYD7, HEMH_RICB8;  Q1RGK5, HEMH_RICBR;  
A8F0B2, HEMH_RICCK;  Q92FV4, HEMH_RICCN;  Q4UJN9, HEMH_RICFE;  
Q9ZC84, HEMH_RICPR;  Q68VM9, HEMH_RICTY;  B7K399, HEMH_RIPO1;  
B5EXN2, HEMH_SALA4;  A9MLY4, HEMH_SALAR;  Q57S74, HEMH_SALCH;  
B5FLJ9, HEMH_SALDC;  B5QU78, HEMH_SALEP;  B5R613, HEMH_SALG2;  
B4T9I3, HEMH_SALHS;  B4SWY3, HEMH_SALNS;  Q5PFJ1, HEMH_SALPA;  
A9MW82, HEMH_SALPB;  C0PVE1, HEMH_SALPC;  B5BD43, HEMH_SALPK;  
B4TMG7, HEMH_SALSV;  Q8Z8T2, HEMH_SALTI;  P37408, HEMH_SALTY;  
O59786, HEMH_SCHPO;  A8GAV7, HEMH_SERP5;  Q12KR9, HEMH_SHEDO;  
B2U4S8, HEMH_SHIB3;  Q325C1, HEMH_SHIBS;  Q32J55, HEMH_SHIDS;  
Q0T7B0, HEMH_SHIF8;  Q83SE5, HEMH_SHIFL;  Q3Z4S4, HEMH_SHISS;  
Q2NV56, HEMH_SODGM;  B4SNS0, HEMH_STRM5;  Q30S35, HEMH_SULDN;  
B2V955, HEMH_SULSY;  Q31S00, HEMH_SYNE7;  Q2JVK5, HEMH_SYNJA;  
Q2JHZ4, HEMH_SYNJB;  B1XL79, HEMH_SYNP2;  Q5N2B2, HEMH_SYNP6;  
A5GJF5, HEMH_SYNPW;  Q7U5G0, HEMH_SYNPX;  A5GS98, HEMH_SYNR3;  
Q0I8L9, HEMH_SYNS3;  Q3ALP2, HEMH_SYNSC;  P54225, HEMH_SYNY3;  
C5BIF4, HEMH_TERTT;  Q9HLB8, HEMH_THEAC;  Q8DGU6, HEMH_THEEB;  
Q72L32, HEMH_THET2;  Q978U9, HEMH_THEVO;  Q3SHA3, HEMH_THIDA;  
B8GU82, HEMH_THISH;  Q10WR6, HEMH_TRIEI;  Q3MCT9, HEMH_TRIV2;  
B7VII4, HEMH_VIBA3;  Q9KTB6, HEMH_VIBCH;  Q87RH3, HEMH_VIBPA;  
Q8DFM2, HEMH_VIBVU;  Q7MMR4, HEMH_VIBVY;  Q8D226, HEMH_WIGBR;  
Q73FY6, HEMH_WOLPM;  B3CLU1, HEMH_WOLPP;  Q7M7P9, HEMH_WOLSU;  
Q5GRR7, HEMH_WOLTR;  C0R4L0, HEMH_WOLWR;  Q8PEX0, HEMH_XANAC;  
Q8P3H6, HEMH_XANCP;  O57478, HEMH_XENLA;  B2I7H7, HEMH_XYLF2;  
Q9PFU1, HEMH_XYLFA;  B0U456, HEMH_XYLFM;  Q87B82, HEMH_XYLFT;  
P16622, HEMH_YEAST;  A1JNA4, HEMH_YERE8;  P43413, HEMH_YEREN;  
A7FL85, HEMH_YERP3;  Q1C4Q0, HEMH_YERPA;  B2K6Z7, HEMH_YERPB;  
Q8ZC98, HEMH_YERPE;  A9R0Q8, HEMH_YERPG;  Q1CL26, HEMH_YERPN;  
A4TPA3, HEMH_YERPP;  Q05338, HEMH_YERPS;  B1JHN0, HEMH_YERPY;  
P57779, HEMH_ZYMMO;  

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