Accepted Name |
sirohydrochlorin cobaltochelatase
|
Alternative Name(s) |
anaerobic cobalt chelatase |
cobaltochelatase |
Reaction catalysed |
- Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin
- Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2
|
Comment(s) |
- This enzyme, which forms part of the anaerobic (early cobalt
insertion) cobalamin biosynthesis pathway, is a type II chelatase.
- It is ATP-independent and exists as either a monomer (CbiX) or a
homodimer (CibK).
- CbiK from Salmonella enterica uses precorrin-2 as the substrate to
yield cobalt-precorrin-2.
- The enzyme contains two histidines at the active site that are
thought to be involved in the deprotonation of the tetrapyrrole
substrate as well as in metal binding.
- CbiX from Bacillus megaterium inserts cobalt at the level of
sirohydrochlorin (factor-II) rather than precorrin-2.
- See EC 6.6.1.2 for the cobaltochelatase that participates in the
aerobic cobalamin biosynthesis pathway.
|
Cross-references |
BRENDA | 4.99.1.3 |
EC2PDB | 4.99.1.3 |
ExplorEnz | 4.99.1.3 |
PRIAM enzyme-specific profiles | 4.99.1.3 |
KEGG Ligand Database for Enzyme Nomenclature | 4.99.1.3 |
IUBMB Enzyme Nomenclature | 4.99.1.3 |
IntEnz | 4.99.1.3 |
MEDLINE | Find literature relating to 4.99.1.3 |
MetaCyc | 4.99.1.3 |
Rhea expert-curated reactions | 4.99.1.3 |
UniProtKB/Swiss-Prot |
Q72CB8, CBIKC_NITV2 | Q72EC8, CBIKP_NITV2 | Q05592, CBIK_SALTY |
O29537, CBIX_ARCFU | Q9HQM3, CBIX_HALSA | O87690, CBIX_PRIMG |
Q980A7, CBIX_SACS2 | Q4JAI2, CBIX_SULAC | C3MZ53, CBIX_SULIA |
C4KID1, CBIX_SULIK | C3MR05, CBIX_SULIL | C3MWZ3, CBIX_SULIM |
C3NGG2, CBIX_SULIN | C3N773, CBIX_SULIY | Q975N6, CBIX_SULTO |
Q55451, CBIX_SYNY3 | A6UWT5, CFBA_META3 | Q8TJZ5, CFBA_METAC |
P61816, CFBA_METBF | Q12X56, CFBA_METBU | Q58380, CFBA_METJA |
Q8TY77, CFBA_METKA | Q8PZH6, CFBA_METMA | P61819, CFBA_METMP |
O27448, CFBA_METTH |
|
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