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ENZYME entry: EC

Accepted Name
Alternative Name(s)
Hydrogenobyrinic acid a,c-diamide cobaltochelatase.
Reaction catalysed
ATP + hydrogenobyrinic acid a,c-diamide + Co(2+) + H(2)O <=> ADP + phosphate + cob(II)yrinic acid a,c-diamide + H(2)
  • This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP- dependent.
  • It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST.
  • Hydrogenobyrinic acid is a very poor substrate.
  • ATP can be replaced by dATP or CTP but the reaction proceeds more slowly.
  • CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide.
  • The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding.
  • Once the Co(2+) is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I); this step is carried out by EC
PRIAM enzyme-specific profiles6.6.1.2
KEGG Ligand Database for Enzyme Nomenclature6.6.1.2
IUBMB Enzyme Nomenclature6.6.1.2
MEDLINEFind literature relating to
P29934, COBT_SINSX;  

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