ENZYME entry: EC 6.6.1.2
Accepted Name |
Cobaltochelatase.
|
Alternative Name(s) |
Hydrogenobyrinic acid a,c-diamide cobaltochelatase. |
Reaction catalysed |
ATP + hydrogenobyrinate a,c-diamide + Co(2+) + H(2)O <=> ADP + phosphate + cob(II)yrinate a,c-diamide + H(2) |
Comment(s) |
- This enzyme, which forms part of the aerobic (late cobalt insertion)
cobalamin biosynthesis pathway, is a type I chelatase, being
heterotrimeric and ATP-dependent.
- It comprises two components, one of which corresponds to CobN and the
other is composed of two polypeptides, specified by cobS and cobT in
Pseudomonas denitrificans, and named CobST.
- Hydrogenobyrinate is a very poor substrate.
- ATP can be replaced by dATP or CTP but the reaction proceeds more
slowly.
- CobN exhibits a high affinity for hydrogenobyrinate a,c-diamide.
- The oligomeric protein CobST possesses at least one sulfhydryl group
that is essential for ATP-binding.
- See EC 4.99.1.3 for the cobaltochelatase that participates in the
anaerobic cobalamin biosynthesis pathway.
|
Cross-references |
BRENDA | 6.6.1.2 |
EC2PDB | 6.6.1.2 |
ExplorEnz | 6.6.1.2 |
PRIAM enzyme-specific profiles | 6.6.1.2 |
KEGG Ligand Database for Enzyme Nomenclature | 6.6.1.2 |
IUBMB Enzyme Nomenclature | 6.6.1.2 |
IntEnz | 6.6.1.2 |
MEDLINE | Find literature relating to 6.6.1.2 |
MetaCyc | 6.6.1.2 |
UniProtKB/Swiss-Prot |
|
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