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ENZYME entry: EC 5.1.99.6

Accepted Name
NAD(P)H-hydrate epimerase
Alternative Name(s)
NAD(P)HX epimerase
Reaction catalysed
  • (6R)-NADHX <=> (6S)-NADHX
  • (6R)-NADPHX <=> (6S)-NADPHX
Comment(s)
  • The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.
  • Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.
Cross-references
BRENDA5.1.99.6
EC2PDB5.1.99.6
ExplorEnz5.1.99.6
PRIAM enzyme-specific profiles5.1.99.6
KEGG Ligand Database for Enzyme Nomenclature5.1.99.6
IUBMB Enzyme Nomenclature5.1.99.6
IntEnz5.1.99.6
MEDLINEFind literature relating to 5.1.99.6
MetaCyc5.1.99.6
Rhea expert-curated reactions5.1.99.6
UniProtKB/Swiss-Prot
E3HVU4, NNRE_ACHXAQ17GW6, NNRE_AEDAEC0NNH7, NNRE_AJECG
C7RGH4, NNRE_ANAPDE3XA68, NNRE_ANODAQ7Q0G5, NNRE_ANOGA
Q4WUG4, NNRE_ASPFUQ7WGX4, NNRE_BORBRQ7W9T3, NNRE_BORPA
F4LHM0, NNRE_BORPCA9IJP4, NNRE_BORPDQ7VVH8, NNRE_BORPE
Q6QRN6, NNRE_BOVINC3YDS7, NNRE_BRAFLA8X5H6, NNRE_CAEBR
Q9XW15, NNRE_CAEELQ59VX9, NNRE_CANALC4YF50, NNRE_CANAW
E2QRY6, NNRE_CANLFA0RY06, NNRE_CENSYB9KJP6, NNRE_CERSK
A5CSB9, NNRE_CLAM3B0RHY9, NNRE_CLAMSQ5KJ55, NNRE_CRYNJ
Q6DHK1, NNRE_DANREE9HCD7, NNRE_DAPPUD8K3Q1, NNRE_DEHLB
Q55CV0, NNRE_DICDIB3N0Q8, NNRE_DROANB3NW64, NNRE_DROER
B4JJQ3, NNRE_DROGRQ9W2Y3, NNRE_DROMEB4L8C7, NNRE_DROMO
B4GWP5, NNRE_DROPEQ29FV5, NNRE_DROPSB4IDM2, NNRE_DROSE
B4M2R8, NNRE_DROVIB4NEH6, NNRE_DROWIB4PXF5, NNRE_DROYA
B2KES3, NNRE_ELUMPC4M2B8, NNRE_ENTH1B0RZQ3, NNRE_FINM2
C7Z508, NNRE_FUSV7A8BQZ5, NNRE_GIAICQ8NCW5, NNRE_HUMAN
E8R1E4, NNRE_ISOPIB7QDG3, NNRE_IXOSCD5TAM8, NNRE_LEGP2
Q5X170, NNRE_LEGPAA5IHZ5, NNRE_LEGPCQ5ZRQ9, NNRE_LEGPH
F4FTW6, NNRE_LENBNB1MW95, NNRE_LEUCKD8MHV4, NNRE_LEUGG
D5T3F2, NNRE_LEUKIQ03UV9, NNRE_LEUMMF8HWV7, NNRE_LEUS2
Q03NP0, NNRE_LEVBAB2GER9, NNRE_LIMF3A5VML0, NNRE_LIMRD
B2G9W3, NNRE_LIMRJF8DQP1, NNRE_LIMRSE8N877, NNRE_MICTS
F7FIH8, NNRE_MONDOQ8K4Z3, NNRE_MOUSEA7RPT4, NNRE_NEMVE
Q7SGL3, NNRE_NEUCRA9A432, NNRE_NITMSQ04HC3, NNRE_OENOB
A0E3W6, NNRE_PARTEE0V9D8, NNRE_PEDHCQ0UZH1, NNRE_PHANO
Q0PIT9, NNRE_PIGD2QYP6, NNRE_PIRSDQ8IKN4, NNRE_PLAF7
B3L9G8, NNRE_PLAKHD5SRZ4, NNRE_PLAL2A5K3F9, NNRE_PLAVS
E3KGP2, NNRE_PUCGTB0BNM1, NNRE_RATQ7ULX4, NNRE_RHOBA
D5ATX8, NNRE_RHOCBF7ZKE9, NNRE_ROSLOF0SLK8, NNRE_RUBBR
O13725, NNRE_SCHPOA7F1E9, NNRE_SCLS1B8LCD8, NNRE_THAPS
D7CWZ0, NNRE_TRURRQ4PB52, NNRE_USTMAF8I1D0, NNRE_WEIKK
F7DL67, NNRE_XENTRQ6CDL0, NNRE_YARLIP40165, NNRE_YEAST
O67377, NNR_AQUAEO29407, NNR_ARCFUQ8NSS3, NNR_CORGL
Q83CM5, NNR_COXBUB8E2P6, NNR_DICTDP31806, NNR_ECOLI
Q7NIE6, NNR_GLOVIQ9ZJM4, NNR_HELPJP56176, NNR_HELPY
A2BLC0, NNR_HYPBUB1L3W1, NNR_KORCOA4H7T9, NNR_LEIBR
A4HW65, NNR_LEIINQ4QFL5, NNR_LEIMAQ2FT57, NNR_METHJ
Q58981, NNR_METJAQ8TX67, NNR_METKAO27324, NNR_METTH
Q2RGI2, NNR_MOOTAP37391, NNR_MYCLEP9WF10, NNR_MYCTO
P9WF11, NNR_MYCTUQ8ZV04, NNR_PYRAEQ2S580, NNR_SALRD
P74217, NNR_SYNY3D1BAA5, NNR_THEASQ9X024, NNR_THEMA
A1S0R2, NNR_THEPDQ8DGC3, NNR_THEVBB5YIM0, NNR_THEYD
Q9KMX5, NNR_VIBCHQ9LTX3, PPOX1_ARATH

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