A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.2.1.93
| Accepted Name |
|---|
| ATP-dependent NAD(P)H-hydrate dehydratase.
|
| Alternative Name(s) |
|---|
| ATP-dependent H(4)NAD(P)OH dehydratase. |
| Reaction catalysed |
|---|
- ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide <=> ADP + phosphate + NADH
- ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate <=> ADP + phosphate + NADPH
|
| Comment(s) |
|---|
- Acts equally well on hydrated NADH and hydrated NADPH.
- NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers,
and these are interconverted by EC 5.1.99.6, to a 60:40 ratio.
- Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture
of hydrates into NAD(P)H.
- The enzyme from eukaryotes has no activity with ADP, contrary to the
enzyme from bacteria (cf. EC 4.2.1.136).
|
| Cross-references |
|---|
| BRENDA | 4.2.1.93 |
| EC2PDB | 4.2.1.93 |
| ExplorEnz | 4.2.1.93 |
| PRIAM enzyme-specific profiles | 4.2.1.93 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.93 |
| IUBMB Enzyme Nomenclature | 4.2.1.93 |
| IntEnz | 4.2.1.93 |
| MEDLINE | Find literature relating to 4.2.1.93 |
| MetaCyc | 4.2.1.93 |
| UniProtKB/Swiss-Prot |
| E3LAQ9, NNRD1_PUCGT; | E3L9T1, NNRD2_PUCGT; | Q17NP0, NNRD_AEDAE; |
| C0NFV9, NNRD_AJECG; | E3XDZ8, NNRD_ANODA; | Q94AF2, NNRD_ARATH; |
| Q4X1F8, NNRD_ASPFU; | F4NZ38, NNRD_BATDJ; | E1BNQ4, NNRD_BOVIN; |
| A8X354, NNRD_CAEBR; | P32740, NNRD_CAEEL; | Q59M69, NNRD_CANAL; |
| C4YSU5, NNRD_CANAW; | E2QUI9, NNRD_CANLF; | F6RCC2, NNRD_CIOIN; |
| A8N8Z0, NNRD_COPC7; | Q5K8L4, NNRD_CRYNJ; | F1Q575, NNRD_DANRE; |
| Q54FJ9, NNRD_DICDI; | Q9VVW8, NNRD_DROME; | B5DHB2, NNRD_DROPS; |
| Q5B0D6, NNRD_EMENI; | C4LZV8, NNRD_ENTHI; | Q8IW45, NNRD_HUMAN; |
| B7PBI5, NNRD_IXOSC; | F7E727, NNRD_MACMU; | Q9CZ42, NNRD_MOUSE; |
| C7YKN8, NNRD_NECH7; | A7RRZ8, NNRD_NEMVE; | Q7SHU9, NNRD_NEUCR; |
| E0VSF4, NNRD_PEDHC; | Q0UVK8, NNRD_PHANO; | B7FXE8, NNRD_PHATC; |
| A9RY03, NNRD_PHYPA; | D3BMU4, NNRD_POLPP; | Q5R824, NNRD_PONAB; |
| D4AAT7, NNRD_RAT; | O94347, NNRD_SCHPO; | C5Y210, NNRD_SORBI; |
| Q4P219, NNRD_USTMA; | F6HDM2, NNRD_VITVI; | P36059, NNRD_YEAST; |
|
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