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ENZYME entry: EC 4.2.1.93

Accepted Name
ATP-dependent NAD(P)H-hydrate dehydratase.
Alternative Name(s)
ATP-dependent H(4)NAD(P)OH dehydratase.
Reaction catalysed
  • ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide <=> ADP + phosphate + NADH
  • ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate <=> ADP + phosphate + NADPH
Comment(s)
  • Acts equally well on hydrated NADH and hydrated NADPH.
  • NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, to a 60:40 ratio.
  • Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H.
  • The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136).
Cross-references
BRENDA4.2.1.93
EC2PDB4.2.1.93
ExplorEnz4.2.1.93
PRIAM enzyme-specific profiles4.2.1.93
KEGG Ligand Database for Enzyme Nomenclature4.2.1.93
IUBMB Enzyme Nomenclature4.2.1.93
IntEnz4.2.1.93
MEDLINEFind literature relating to 4.2.1.93
MetaCyc4.2.1.93
Rhea expert-curated reactions4.2.1.93
UniProtKB/Swiss-Prot
E3LAQ9, NNRD1_PUCGT;  E3L9T1, NNRD2_PUCGT;  Q17NP0, NNRD_AEDAE;  
C0NFV9, NNRD_AJECG;  E3XDZ8, NNRD_ANODA;  Q94AF2, NNRD_ARATH;  
Q4X1F8, NNRD_ASPFU;  F4NZ38, NNRD_BATDJ;  E1BNQ4, NNRD_BOVIN;  
A8X354, NNRD_CAEBR;  P32740, NNRD_CAEEL;  Q59M69, NNRD_CANAL;  
C4YSU5, NNRD_CANAW;  E2QUI9, NNRD_CANLF;  F6RCC2, NNRD_CIOIN;  
A8N8Z0, NNRD_COPC7;  Q5K8L4, NNRD_CRYNJ;  F1Q575, NNRD_DANRE;  
Q54FJ9, NNRD_DICDI;  Q9VVW8, NNRD_DROME;  B5DHB2, NNRD_DROPS;  
Q5B0D6, NNRD_EMENI;  C4LZV8, NNRD_ENTHI;  C7YKN8, NNRD_FUSV7;  
Q8IW45, NNRD_HUMAN;  B7PBI5, NNRD_IXOSC;  F7E727, NNRD_MACMU;  
Q9CZ42, NNRD_MOUSE;  A7RRZ8, NNRD_NEMVE;  Q7SHU9, NNRD_NEUCR;  
E0VSF4, NNRD_PEDHC;  Q0UVK8, NNRD_PHANO;  B7FXE8, NNRD_PHATC;  
A9RY03, NNRD_PHYPA;  D3BMU4, NNRD_POLPP;  Q5R824, NNRD_PONAB;  
D4AAT7, NNRD_RAT;  O94347, NNRD_SCHPO;  C5Y210, NNRD_SORBI;  
Q4P219, NNRD_USTMA;  F6HDM2, NNRD_VITVI;  P36059, NNRD_YEAST;  

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