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ENZYME

ENZYME entry: EC 4.2.1.93

Accepted Name
ATP-dependent NAD(P)H-hydrate dehydratase
Alternative Name(s)
ATP-dependent H4NAD(P)OH dehydratase
Reaction catalysed
  • (6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate
  • (6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate
Comment(s)
  • Acts equally well on hydrated NADH and hydrated NADPH.
  • NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, to a 60:40 ratio.
  • Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H.
  • The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136).
Cross-references
BRENDA4.2.1.93
EC2PDB4.2.1.93
ExplorEnz4.2.1.93
PRIAM enzyme-specific profiles4.2.1.93
KEGG Ligand Database for Enzyme Nomenclature4.2.1.93
IUBMB Enzyme Nomenclature4.2.1.93
IntEnz4.2.1.93
MEDLINEFind literature relating to 4.2.1.93
MetaCyc4.2.1.93
Rhea expert-curated reactions4.2.1.93
UniProtKB/Swiss-Prot
E3LAQ9, NNRD1_PUCGTE3L9T1, NNRD2_PUCGTQ17NP0, NNRD_AEDAE
C0NFV9, NNRD_AJECGE3XDZ8, NNRD_ANODAQ94AF2, NNRD_ARATH
Q4X1F8, NNRD_ASPFUF4NZ38, NNRD_BATDJE1BNQ4, NNRD_BOVIN
A8X354, NNRD_CAEBRP32740, NNRD_CAEELQ59M69, NNRD_CANAL
C4YSU5, NNRD_CANAWE2QUI9, NNRD_CANLFF6RCC2, NNRD_CIOIN
A8N8Z0, NNRD_COPC7Q5K8L4, NNRD_CRYNJF1Q575, NNRD_DANRE
Q54FJ9, NNRD_DICDIQ9VVW8, NNRD_DROMEB5DHB2, NNRD_DROPS
Q5B0D6, NNRD_EMENIC4LZV8, NNRD_ENTH1C7YKN8, NNRD_FUSV7
D3BMU4, NNRD_HETP5Q8IW45, NNRD_HUMANB7PBI5, NNRD_IXOSC
F7E727, NNRD_MACMUQ9CZ42, NNRD_MOUSEA7RRZ8, NNRD_NEMVE
Q7SHU9, NNRD_NEUCRE0VSF4, NNRD_PEDHCQ0UVK8, NNRD_PHANO
B7FXE8, NNRD_PHATCA9RY03, NNRD_PHYPAQ5R824, NNRD_PONAB
D4AAT7, NNRD_RATO94347, NNRD_SCHPOC5Y210, NNRD_SORBI
Q4P219, NNRD_USTMAF6HDM2, NNRD_VITVIP36059, NNRD_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-