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ENZYME entry: EC 5.3.3.23

Accepted Name
S-methyl-5-thioribulose 1-phosphate isomerase.
Alternative Name(s)
5-methylthioribulose-1-phosphate isomerase.
Reaction catalysed
  • S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate
  • S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate
Comment(s)
  • The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine.
  • It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyzes an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl- 1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate.
  • The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.
Cross-references
BRENDA5.3.3.23
EC2PDB5.3.3.23
ExplorEnz5.3.3.23
PRIAM enzyme-specific profiles5.3.3.23
KEGG Ligand Database for Enzyme Nomenclature5.3.3.23
IUBMB Enzyme Nomenclature5.3.3.23
IntEnz5.3.3.23
MEDLINEFind literature relating to 5.3.3.23
MetaCyc5.3.3.23
Rhea expert-curated reactions5.3.3.23
UniProtKB/Swiss-Prot
Q2RSU7, RLP_RHORT

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