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ENZYME entry: EC 5.3.99.12

Accepted Name
lachrymatory-factor synthase.
Alternative Name(s)
LFS.
Reaction catalysed
(E)-alk-1-en-1-SO-peroxol <=> (Z)-alkanethial oxide
Comment(s)
  • The enzyme is responsible for production of the irritating lachrymatory factor that is released by onions and related species when they are chopped.
  • It acts on the product of EC 4.4.1.4.
  • The enzyme from Allium cepa (onion) acts on (E)-prop-1-en-1- SO-peroxol and produces (Z)-propanethial oxide, while the enzyme from Allium siculum (honey garlic) acts on (E)-but-1-en-1-SO-peroxol and produces (Z)-butanethial oxide.
Cross-references
BRENDA5.3.99.12
EC2PDB5.3.99.12
ExplorEnz5.3.99.12
PRIAM enzyme-specific profiles5.3.99.12
KEGG Ligand Database for Enzyme Nomenclature5.3.99.12
IUBMB Enzyme Nomenclature5.3.99.12
IntEnz5.3.99.12
MEDLINEFind literature relating to 5.3.99.12
MetaCyc5.3.99.12
Rhea expert-curated reactions5.3.99.12

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-