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ENZYME

ENZYME entry: EC 5.3.99.13

Accepted Name
4'-phospho-dehydrooxetanocin synthase
Reaction catalysed
dAMP + S-adenosyl-L-methionine = 4'-phospho-dehydrooxetanocin + 5'-deoxyadenosine + L-methionine + H(+)
Comment(s)
  • The enzyme is a B12-dependent radical SAM (AdoMet) enzyme involved in the biosynthesis of oxetanocin A.
  • The enzyme catalyzes an oxidative ring contraction, forming an oxetane aldehyde.
  • The reaction requires S-adenosyl-L-methionine, a cobalamin cofactor, and a reductant (the reductant does not show in the overall reaction because it is being restored during the cycle).
  • The reaction is initiated by formation of 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen atom from C2'.
  • The enzyme is also able to catalyze the radical mediated, stereoselective C2'-methylation of dAMP.
Cross-references
BRENDA5.3.99.13
EC2PDB5.3.99.13
ExplorEnz5.3.99.13
PRIAM enzyme-specific profiles5.3.99.13
KEGG Ligand Database for Enzyme Nomenclature5.3.99.13
IUBMB Enzyme Nomenclature5.3.99.13
IntEnz5.3.99.13
MEDLINEFind literature relating to 5.3.99.13
MetaCyc5.3.99.13
Rhea expert-curated reactions5.3.99.13
UniProtKB/Swiss-Prot
O24770, OXSB_PRIMG

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