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ENZYME

ENZYME entry: EC 5.4.99.25

PURL: https://purl.expasy.org/enzyme/EC/5.4.99.25
Accepted Name
tRNA pseudouridine(55) synthase
Alternative Name(s)
Psi(55) synthase
Psi(55) tRNA pseudouridine synthase
tRNA pseudouridine 55 synthase
tRNA Psi(55) synthase
Reaction catalysed
uridine(55) in tRNA = pseudouridine(55) in tRNA
Comment(s)
  • Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules.
  • The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54).
  • It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
Cross-references
BRENDA5.4.99.25
EC2PDB5.4.99.25
ExplorEnz5.4.99.25
KEGG Ligand Database for Enzyme Nomenclature5.4.99.25
IUBMB Enzyme Nomenclature5.4.99.25
MEDLINEFind literature relating to 5.4.99.25
MetaCyc5.4.99.25
Rhea expert-curated reactions5.4.99.25
UniProtKB/Swiss-Prot
D9PZU4, PUS10_ACIS3Q9YEN2, PUS10_AERPEO29113, PUS10_ARCFU
A8MDD0, PUS10_CALMQA0RUP0, PUS10_CENSYQ9VPK7, PUS10_DROME
B9LQ94, PUS10_HALLTQ3MIT2, PUS10_HUMANE0SNQ8, PUS10_IGNAA
B1L7A7, PUS10_KORCOQ60346, PUS10_METJAQ8TUV7, PUS10_METKA
Q2NE45, PUS10_METSTD9PYH9, PUS10_METTMA0B7V3, PUS10_METTP
D7DQH5, PUS10_METV3Q9D3U0, PUS10_MOUSEA9A215, PUS10_NITMS
Q6L227, PUS10_PICTOA4WLQ5, PUS10_PYRARQ8U1R6, PUS10_PYRFU
Q9HIN9, PUS10_THEACD5TZL3, PUS10_THEAMA1RX33, PUS10_THEPD
E1QUT8, PUS10_VULDIQ6ING2, PUS10_XENLAO59721, PUS4_SCHPO
P48567, PUS4_YEASTQ8WWH5, TRUB1_HUMANQ8C0D0, TRUB1_MOUSE
Q5M934, TRUB1_RATO95900, TRUB2_HUMANQ91WG3, TRUB2_MOUSE
Q5XFW2, TRUB2_RATQ5XGG2, TRUB2_XENTRB0CCH1, TRUB_ACAM1
A9NGE6, TRUB_ACHLIQ6F7I5, TRUB_ACIADA3N007, TRUB_ACTP2
A6VNE2, TRUB_ACTSZQ9YDC3, TRUB_AERPEA4SJR7, TRUB_AERS4
Q8UJ53, TRUB_AGRFCQ5E7L3, TRUB_ALIF1B5FA81, TRUB_ALIFM
B6ENE4, TRUB_ALISLA8MFB1, TRUB_ALKOOQ5PAY2, TRUB_ANAMM
Q2GJV3, TRUB_ANAPZO66922, TRUB_AQUAEO30001, TRUB_ARCFU
Q5NZR9, TRUB_AROAEA0JUU8, TRUB_ARTS2Q2NIZ2, TRUB_AYWBP
A1K7B7, TRUB_AZOSBA0RHI1, TRUB_BACAHP59873, TRUB_BACAN
Q732R2, TRUB_BACC1A7GRE0, TRUB_BACCNQ812X9, TRUB_BACCR
Q636L6, TRUB_BACCZQ5LJ29, TRUB_BACFNQ650L8, TRUB_BACFR
Q6HF05, TRUB_BACHKQ65JH8, TRUB_BACLDA8FDD4, TRUB_BACP2
P32732, TRUB_BACSUQ8A2U2, TRUB_BACTNA7Z4T7, TRUB_BACVZ
A1UU52, TRUB_BARBKQ6G5F5, TRUB_BARHEQ6G0P4, TRUB_BARQU
A9IMS8, TRUB_BART1Q1LSL0, TRUB_BAUCHQ6MMS4, TRUB_BDEBA
B3DQF2, TRUB_BIFLDQ8CY45, TRUB_BIFLOB7GNA1, TRUB_BIFLS
P59877, TRUB_BLOFLQ493T5, TRUB_BLOPBQ2KXZ0, TRUB_BORA1
Q0SM48, TRUB_BORAPP65853, TRUB_BORBRO51743, TRUB_BORBU
B7J0P9, TRUB_BORBZQ65ZX0, TRUB_BORGPP59874, TRUB_BORPA
P65852, TRUB_BORPEQ89WB1, TRUB_BRADUQ2YQR5, TRUB_BRUA2
A6WWW3, TRUB_BRUA4Q57A98, TRUB_BRUABA9M9Z6, TRUB_BRUC2
Q8YEB5, TRUB_BRUMEA5VTB4, TRUB_BRUO2B0CK13, TRUB_BRUSI
P59876, TRUB_BRUSUP57456, TRUB_BUCAIQ8K9H3, TRUB_BUCAP
Q89AF6, TRUB_BUCBPQ39H28, TRUB_BURL3A3MJW6, TRUB_BURM7
Q62KL1, TRUB_BURMAA3NUL2, TRUB_BURP0Q3JSY7, TRUB_BURP1
A3N8W0, TRUB_BURP6Q63TQ0, TRUB_BURPSQ8RA40, TRUB_CALS4
A4XL67, TRUB_CALS8A7ZE50, TRUB_CAMC1A7GZ93, TRUB_CAMC5
A8FMF5, TRUB_CAMJ8A7H2Q5, TRUB_CAMJDQ9PNJ2, TRUB_CAMJE
A1W089, TRUB_CAMJJQ5HU02, TRUB_CAMJRQ3ABA1, TRUB_CARHZ
B0T173, TRUB_CAUSKP58063, TRUB_CAUVCA3PNF6, TRUB_CERS1
Q3IYU1, TRUB_CERS4A4WWP4, TRUB_CERS5Q11BC6, TRUB_CHESB
Q5L629, TRUB_CHLABQ3AQK9, TRUB_CHLCHQ254H2, TRUB_CHLFF
Q3B200, TRUB_CHLL3Q9PKU2, TRUB_CHLMUA4SGG0, TRUB_CHLPM
Q9Z8L9, TRUB_CHLPNB0B9K2, TRUB_CHLT2B3QZ05, TRUB_CHLT3
B0BB81, TRUB_CHLTBQ8KFS9, TRUB_CHLTEO84096, TRUB_CHLTR
Q1QSZ2, TRUB_CHRI1Q7MBF7, TRUB_CHRVOA8AQ55, TRUB_CITK8
Q97I48, TRUB_CLOABA7GG03, TRUB_CLOBLQ18BH7, TRUB_CLOD6
A5N845, TRUB_CLOK5A0Q0Q4, TRUB_CLONNQ0TPS0, TRUB_CLOP1
Q8XJS1, TRUB_CLOPEQ0SSD7, TRUB_CLOPSQ895J5, TRUB_CLOTE
Q482T7, TRUB_COLP3C3PH13, TRUB_CORA7P60343, TRUB_CORDI
Q8FPB3, TRUB_COREFA4QEY6, TRUB_CORGBQ8NP46, TRUB_CORGL
Q4JV56, TRUB_CORJKA9KBM3, TRUB_COXBNA9N8V4, TRUB_COXBR
Q4AAX7, TRUB_COXBUA7MQD9, TRUB_CROS8Q1LLR8, TRUB_CUPMC
Q46ZP3, TRUB_CUPPJB3R1E2, TRUB_CUPTRQ6A7P0, TRUB_CUTAK
Q47D96, TRUB_DECARQ3Z7U5, TRUB_DEHM1A5FQR4, TRUB_DEHMB
Q3ZXU5, TRUB_DEHMCC1D1L3, TRUB_DEIDVQ1J0C1, TRUB_DEIGD
Q9RUQ9, TRUB_DEIRAQ6AJY7, TRUB_DESPSA8LL26, TRUB_DINSH
A7ZS63, TRUB_ECO24P60342, TRUB_ECO57A8A4Y2, TRUB_ECOHS
A1AG71, TRUB_ECOK1Q0TCU3, TRUB_ECOL5P60341, TRUB_ECOL6
B1IQV5, TRUB_ECOLCP60340, TRUB_ECOLIQ1R6H2, TRUB_ECOUT
A4XYD8, TRUB_ECTM1Q3YSC6, TRUB_EHRCJQ2GGA2, TRUB_EHRCR
Q5FHK7, TRUB_EHRRGQ5HBH8, TRUB_EHRRWB1GZN9, TRUB_ENDTX
A4WEY1, TRUB_ENT38Q9RB36, TRUB_FLAJ1B0TXH9, TRUB_FRAP2
Q14G67, TRUB_FRAT1A7NAR1, TRUB_FRATFQ2A4N1, TRUB_FRATH
A0Q7W5, TRUB_FRATNQ0BN06, TRUB_FRATOQ5NER4, TRUB_FRATT
A4IWL0, TRUB_FRATWQ8R5X8, TRUB_FUSNNQ5L0I5, TRUB_GEOKA
Q39VA3, TRUB_GEOMGP60344, TRUB_GEOSLA4IME0, TRUB_GEOTN
A5GF89, TRUB_GEOURB7KGX7, TRUB_GLOC7Q7MBB8, TRUB_GLOVI
A9HF26, TRUB_GLUDAQ5FQM1, TRUB_GLUOXP59878, TRUB_HAEDU
Q4QK43, TRUB_HAEI8A5UBU2, TRUB_HAEIEA5UF28, TRUB_HAEIG
P45142, TRUB_HAEINQ2SML1, TRUB_HAHCHQ9KA80, TRUB_HALH5
A1WXU9, TRUB_HALHLQ5UXH1, TRUB_HALMAB0R686, TRUB_HALS3
Q9HPA4, TRUB_HALSAC4K3E8, TRUB_HAMD5Q7U330, TRUB_HELHP
B0THR7, TRUB_HELMIQ8GB99, TRUB_HELMOQ0I3P3, TRUB_HISS1
B0UU15, TRUB_HISS2Q31GK3, TRUB_HYDCUQ5QTZ0, TRUB_IDILO
Q28K11, TRUB_JANSCA6TEI5, TRUB_KLEP7B1L793, TRUB_KORCO
Q5FJN8, TRUB_LACACB3WER2, TRUB_LACCBQ1G9Q1, TRUB_LACDA
Q049V7, TRUB_LACDBQ044B5, TRUB_LACGAQ74IT0, TRUB_LACJO
Q9CGH0, TRUB_LACLAA2RL47, TRUB_LACLMQ02Z55, TRUB_LACLS
Q038M8, TRUB_LACP3A9KNW1, TRUB_LACP7Q88VL5, TRUB_LACPL
Q38W87, TRUB_LATSSQ5X1C5, TRUB_LEGPAA5IHU5, TRUB_LEGPC
Q5ZRV6, TRUB_LEGPHQ5WT38, TRUB_LEGPLQ6AG41, TRUB_LEIXX
Q72NX5, TRUB_LEPICQ8CXU1, TRUB_LEPINQ03QT7, TRUB_LEVBA
Q1WUF2, TRUB_LIGS1A5VJE2, TRUB_LIMRDQ92C26, TRUB_LISIN
Q71ZZ4, TRUB_LISMFQ8Y7F3, TRUB_LISMOA0AIC9, TRUB_LISW6
Q8CXQ2, TRUB_MALP2Q65SL2, TRUB_MANSMQ0AK64, TRUB_MARMM
A6VU31, TRUB_MARMSA1U5Z8, TRUB_MARN8Q6F1I4, TRUB_MESFL
Q601U7, TRUB_MESH2A6UWC6, TRUB_META3Q8TRR5, TRUB_METAC
Q46GC3, TRUB_METBFQ609C2, TRUB_METCAQ1GXD4, TRUB_METFK
Q57612, TRUB_METJAQ8TZ08, TRUB_METKAA4G0N3, TRUB_METM5
A9A8X7, TRUB_METM6A6VHV2, TRUB_METM7Q8PV20, TRUB_METMA
Q6LWM3, TRUB_METMPO26140, TRUB_METTHB0JJJ5, TRUB_MICAN
Q2RJM2, TRUB_MOOTAA0QIX1, TRUB_MYCA1B1MD72, TRUB_MYCA9
P62189, TRUB_MYCBOA1KMD6, TRUB_MYCBPQ2SSF2, TRUB_MYCCT
P59879, TRUB_MYCGAQ9Z5I4, TRUB_MYCLEQ6KHH8, TRUB_MYCM1
Q6MTR0, TRUB_MYCMSQ73VW3, TRUB_MYCPAQ98Q19, TRUB_MYCPU
A3PY88, TRUB_MYCSJA1UET1, TRUB_MYCSKQ1BA81, TRUB_MYCSS
A5U6E6, TRUB_MYCTAP9WHP6, TRUB_MYCTOP9WHP7, TRUB_MYCTU
A0PQD9, TRUB_MYCUAP60346, TRUB_NANEQQ5F8W8, TRUB_NEIG1
B4RMB1, TRUB_NEIG2Q9JTX5, TRUB_NEIMAQ9JYY1, TRUB_NEIMB
Q820P2, TRUB_NITEUQ2Y7W4, TRUB_NITMUQ3J9B8, TRUB_NITOC
A6Q522, TRUB_NITSBQ72ER4, TRUB_NITV2B8DN09, TRUB_NITV9
Q3SWP7, TRUB_NITWNQ5YSE0, TRUB_NOCFAQ8YWR1, TRUB_NOSS1
Q2G5F3, TRUB_NOVADQ8CXG9, TRUB_OCEIHQ04ED7, TRUB_OENOB
Q30WI7, TRUB_OLEA2Q6YQY6, TRUB_ONYPEB1ZX46, TRUB_OPITP
A1R520, TRUB_PAEATA6LEL7, TRUB_PARD8A1B5U1, TRUB_PARDP
P59884, TRUB_PARMWQ6MD66, TRUB_PARUWQ9CMQ7, TRUB_PASMU
Q6D9A3, TRUB_PECASQ03FS1, TRUB_PEDPAA5D2S3, TRUB_PELTS
Q7MAY1, TRUB_PHOLLQ6LUJ0, TRUB_PHOPRA6KZJ9, TRUB_PHOV8
Q6L1A0, TRUB_PICTOA3PEI1, TRUB_PROM0A2C4C0, TRUB_PROM1
A8G6F8, TRUB_PROM2A2BY54, TRUB_PROM5Q319E0, TRUB_PROM9
P59880, TRUB_PROMAP59881, TRUB_PROMMP59882, TRUB_PROMP
A2BSS0, TRUB_PROMSQ46JB9, TRUB_PROMTQ48E79, TRUB_PSE14
Q15V70, TRUB_PSEA6Q02FT0, TRUB_PSEABP72154, TRUB_PSEAE
Q1IF41, TRUB_PSEE4Q4KIF4, TRUB_PSEF5A5W985, TRUB_PSEP1
A6VCJ9, TRUB_PSEP7Q3KI82, TRUB_PSEPFB0KHX6, TRUB_PSEPG
Q3IJ75, TRUB_PSET1Q4ZNR4, TRUB_PSEU2Q4FVL3, TRUB_PSYA2
Q1QEP3, TRUB_PSYCKA1ST47, TRUB_PSYINQ9V1A5, TRUB_PYRAB
Q8ZYB3, TRUB_PYRAEA4WH37, TRUB_PYRARA3MS77, TRUB_PYRCJ
Q7LWY0, TRUB_PYRFUO59357, TRUB_PYRHOA1RTL7, TRUB_PYRIL
B1YA64, TRUB_PYRNVQ8XZV4, TRUB_RALN1B2UAA5, TRUB_RALPJ
Q2KDZ7, TRUB_RHIECQ1MN41, TRUB_RHIJ3Q98BI6, TRUB_RHILO
Q92SW2, TRUB_RHIMEP59883, TRUB_RHOBAQ0S212, TRUB_RHOJR
P60345, TRUB_RHOPAQ2RMR8, TRUB_RHORTC3PNK4, TRUB_RICAE
A8GNM0, TRUB_RICAHA8GWV0, TRUB_RICB8Q1RIG2, TRUB_RICBR
A8EYU0, TRUB_RICCKQ92HV5, TRUB_RICCNQ4ULJ9, TRUB_RICFE
Q9ZD46, TRUB_RICPRC4K0F2, TRUB_RICPUB0BXR2, TRUB_RICRO
A8GS98, TRUB_RICRSQ68WN3, TRUB_RICTYQ16CE8, TRUB_ROSDO
Q5LLT4, TRUB_RUEPOQ1GKJ9, TRUB_RUESTQ21H63, TRUB_SACD2
Q980C3, TRUB_SACS2A9MP38, TRUB_SALARQ57JI1, TRUB_SALCH
Q5PLB2, TRUB_SALPAA9N730, TRUB_SALPBQ8Z3H9, TRUB_SALTI
Q8ZLT2, TRUB_SALTYA8G909, TRUB_SERP5A1S464, TRUB_SHEAM
B8E6N4, TRUB_SHEB2A3D7K4, TRUB_SHEB5A6WRG6, TRUB_SHEB8
A9KZW9, TRUB_SHEB9Q12QH9, TRUB_SHEDOQ086H0, TRUB_SHEFN
B0TQA0, TRUB_SHEHHA3QGU3, TRUB_SHELPA8H738, TRUB_SHEPA
A4Y9B8, TRUB_SHEPCB8CKH5, TRUB_SHEPWA0KTZ8, TRUB_SHESA
Q0HLF9, TRUB_SHESMQ0HXR3, TRUB_SHESRA1RGX7, TRUB_SHESW
B1KRQ8, TRUB_SHEWMQ31W45, TRUB_SHIBSQ32BG7, TRUB_SHIDS
Q0T0B5, TRUB_SHIF8Q83MJ8, TRUB_SHIFLQ3YX75, TRUB_SHISS
Q5WFU5, TRUB_SHOC1A6UF31, TRUB_SINMWQ2NW21, TRUB_SODGM
Q01SZ5, TRUB_SOLUEA7X1Q5, TRUB_STAA1A6U190, TRUB_STAA2
Q2FHG7, TRUB_STAA3Q2G2Q3, TRUB_STAA8A5ISF5, TRUB_STAA9
Q2YXP5, TRUB_STAABQ5HGG0, TRUB_STAACA6QGH0, TRUB_STAAE
P65854, TRUB_STAAMP65855, TRUB_STAANQ6GHG4, TRUB_STAAR
Q6G9U2, TRUB_STAASA8Z3V1, TRUB_STAATQ8NWZ0, TRUB_STAAW
Q5HPS0, TRUB_STAEQQ8CMM6, TRUB_STAESQ4L5X4, TRUB_STAHJ
Q49X59, TRUB_STAS1Q3K189, TRUB_STRA1P65856, TRUB_STRA3
P65857, TRUB_STRA5Q82K56, TRUB_STRAWQ9Z528, TRUB_STRCO
A8AX28, TRUB_STRGCB1VYN2, TRUB_STRGGQ8DU15, TRUB_STRMU
P65858, TRUB_STRP1Q04KA7, TRUB_STRP2P0DD48, TRUB_STRP3
Q5XBX7, TRUB_STRP6P65859, TRUB_STRP8Q1JBI5, TRUB_STRPB
Q1JLG7, TRUB_STRPCQ1JGK3, TRUB_STRPDQ1J6C1, TRUB_STRPF
A2RE90, TRUB_STRPGQ48TB3, TRUB_STRPMQ97QJ3, TRUB_STRPN
P0DD49, TRUB_STRPQQ8CWR2, TRUB_STRR6A3CMF2, TRUB_STRSV
Q5LZV2, TRUB_STRT1Q5M4G2, TRUB_STRT2A4VPN8, TRUB_STUS1
Q30TG2, TRUB_SULDNA6Q784, TRUB_SULNBQ975L5, TRUB_SULTO
Q67P83, TRUB_SYMTHQ2LWU1, TRUB_SYNASQ3A4A3, TRUB_SYNC1
Q8KIY0, TRUB_SYNE7A0LHM2, TRUB_SYNFMQ5N5A0, TRUB_SYNP6
A5GN82, TRUB_SYNPWQ0I7Z1, TRUB_SYNS3Q0AYI5, TRUB_SYNWW
P74696, TRUB_SYNY3Q9HIT4, TRUB_THEACQ47RU8, TRUB_THEFY
C5A255, TRUB_THEGJQ5JJE8, TRUB_THEKOA6LLV6, TRUB_THEM4
Q9WZW0, TRUB_THEMAB6YSP4, TRUB_THEONA5IIS7, TRUB_THEP1
Q72GS9, TRUB_THET2Q5SLS6, TRUB_THET8Q8CWM3, TRUB_THEVB
Q97BU9, TRUB_THEVOQ3SKX3, TRUB_THIDAC4L8X2, TRUB_TOLAT
Q73NP8, TRUB_TREDEO83859, TRUB_TREPAB2S4C6, TRUB_TREPS
Q112N2, TRUB_TRIEIQ3M356, TRUB_TRIV2Q820Z5, TRUB_TROW8
Q820Y5, TRUB_TROWTB1AIZ3, TRUB_UREP2Q9PQD7, TRUB_UREPA
B5ZBG4, TRUB_UREU1A1WLI1, TRUB_VEREIB7VJH5, TRUB_VIBA3
A7MZI3, TRUB_VIBC1A5F928, TRUB_VIBC3Q9KU78, TRUB_VIBCH
C3LSQ0, TRUB_VIBCMQ87M04, TRUB_VIBPAQ8DBV8, TRUB_VIBVU
Q7MI11, TRUB_VIBVYQ8D2X8, TRUB_WIGBRB3CM19, TRUB_WOLPP
Q7M9J1, TRUB_WOLSUQ8PJ57, TRUB_XANACQ4UWA0, TRUB_XANC8
B0RRB6, TRUB_XANCBQ8P7U9, TRUB_XANCPQ3BRP7, TRUB_XANE5
Q2P0X3, TRUB_XANOMQ5GXV1, TRUB_XANORQ9PGR1, TRUB_XYLFA
Q87EV2, TRUB_XYLFTA1JIX1, TRUB_YERE8O34273, TRUB_YEREN
A7FMS0, TRUB_YERP3Q1CC09, TRUB_YERPAQ8ZBC4, TRUB_YERPE
Q1CEL5, TRUB_YERPNA4TRI1, TRUB_YERPPQ66F58, TRUB_YERPS
Q5NQ30, TRUB_ZYMMO

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