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ENZYME entry: EC 5.4.99.58

Accepted Name
Methylornithine synthase.
Reaction catalysed
L-lysine <=> (3R)-3-methyl-D-ornithine
Comment(s)
  • The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes.
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
Cross-references
BRENDA5.4.99.58
EC2PDB5.4.99.58
ExplorEnz5.4.99.58
PRIAM enzyme-specific profiles5.4.99.58
KEGG Ligand Database for Enzyme Nomenclature5.4.99.58
IUBMB Enzyme Nomenclature5.4.99.58
IntEnz5.4.99.58
MEDLINEFind literature relating to 5.4.99.58
MetaCyc5.4.99.58
Rhea expert-curated reactions5.4.99.58
UniProtKB/Swiss-Prot
Q8TUB9, PYLB_METAC;  Q46E78, PYLB_METBF;  

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