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ENZYME

ENZYME entry: EC 5.4.99.64

PURL: https://purl.expasy.org/enzyme/EC/5.4.99.64
Accepted Name
2-hydroxyisobutanoyl-CoA mutase
Reaction catalysed
2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA
Comment(s)
  • The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group.
  • It consists of two subunits, the smaller one containing a cobalamin cofactor.
  • It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety.
  • Formerly EC 5.3.3.20.
Cross-references
BRENDA5.4.99.64
EC2PDB5.4.99.64
ExplorEnz5.4.99.64
KEGG Ligand Database for Enzyme Nomenclature5.4.99.64
IUBMB Enzyme Nomenclature5.4.99.64
MEDLINEFind literature relating to 5.4.99.64
MetaCyc5.4.99.64
Rhea expert-curated reactions5.4.99.64
UniProtKB/Swiss-Prot
I3VE77, HCMA_AQUTEI3VE74, HCMB_AQUTE

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