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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 5.4.99.64

Accepted Name
2-hydroxyisobutanoyl-CoA mutase.
Reaction catalysed
2-hydroxy-2-methylpropanoyl-CoA <=> (S)-3-hydroxybutanoyl-CoA
Comment(s)
  • The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group.
  • It consists of two subunits, the smaller one containing a cobalamin cofactor.
  • It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety.
  • Formerly EC 5.3.3.20.
Cross-references
BRENDA5.4.99.64
EC2PDB5.4.99.64
ExplorEnz5.4.99.64
PRIAM enzyme-specific profiles5.4.99.64
KEGG Ligand Database for Enzyme Nomenclature5.4.99.64
IUBMB Enzyme Nomenclature5.4.99.64
IntEnz5.4.99.64
MEDLINEFind literature relating to 5.4.99.64
MetaCyc5.4.99.64

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-