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ENZYME entry: EC 5.6.1.3

Accepted Name
Plus-end-directed kinesin ATPase.
Alternative Name(s)
Kinesin.
Reaction catalysed
ATP + H(2)O + a kinesin associated with a microtubule at position (n) <=> ADP + phosphate a kinesin associated with a microtubule at position (n+1, toward the plus end)
Comment(s)
  • Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyze ATP.
  • The enzymes described here move toward the plus end of the microtubule, in contrast to EC 5.6.1.2 and EC 5.6.1.4.
  • They are involved in organelle movement in mitosis and meiosis, and also power vesicular trafficking toward the synapse in neurons.
  • The motor domain, which contains the ATP- and microtubule-binding activities, is located at the N-terminus while the C-terminus links to the cargo being transported.
  • Formerly EC 3.6.4.4.
Cross-references
PROSITEPDOC00343
BRENDA5.6.1.3
EC2PDB5.6.1.3
ExplorEnz5.6.1.3
PRIAM enzyme-specific profiles5.6.1.3
KEGG Ligand Database for Enzyme Nomenclature5.6.1.3
IUBMB Enzyme Nomenclature5.6.1.3
IntEnz5.6.1.3
MEDLINEFind literature relating to 5.6.1.3
MetaCyc5.6.1.3

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-