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ENZYME entry: EC 5.6.1.6

Accepted Name
Channel-conductance-controlling ATPase.
Alternative Name(s)
CFTR.
Cystic-fibrosis membrane-conductance-regulating protein.
Reaction catalysed
ATP + H(2)O + closed Cl(-) channel <=> ADP + phosphate + open Cl(-) channel
Comment(s)
  • ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains.
  • The enzyme is found in animals, and in humans its absence brings about cystic fibrosis.
  • Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis.
  • Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains.
  • The enzyme is also involved in the functioning of other transmembrane channels.
  • Formerly EC 3.6.3.49.
Cross-references
PROSITEPDOC00185
BRENDA5.6.1.6
EC2PDB5.6.1.6
ExplorEnz5.6.1.6
PRIAM enzyme-specific profiles5.6.1.6
KEGG Ligand Database for Enzyme Nomenclature5.6.1.6
IUBMB Enzyme Nomenclature5.6.1.6
IntEnz5.6.1.6
MEDLINEFind literature relating to 5.6.1.6
MetaCyc5.6.1.6
UniProtKB/Swiss-Prot
Q07DV2, CFTR_AOTNA;  Q00PJ2, CFTR_ATEAB;  Q09YK5, CFTR_ATEGE;  
P35071, CFTR_BOVIN;  Q2QLF9, CFTR_CALJA;  Q5U820, CFTR_CANLF;  
Q2QLC5, CFTR_CARPS;  Q00552, CFTR_CAVPO;  Q2IBA1, CFTR_CHLAE;  
Q07DY5, CFTR_COLGU;  Q1LX78, CFTR_DANRE;  Q07E42, CFTR_DASNO;  
Q2QL74, CFTR_DIDVI;  Q2IBF6, CFTR_GORGO;  Q2QLA3, CFTR_HORSE;  
P13569, CFTR_HUMAN;  Q108U0, CFTR_LOXAF;  Q7JII8, CFTR_MACFA;  
Q7JII7, CFTR_MACFU;  Q00553, CFTR_MACMU;  Q9TUQ2, CFTR_MACNE;  
Q2QL83, CFTR_MICMU;  P26361, CFTR_MOUSE;  Q09YJ4, CFTR_MUNMU;  
Q07DW5, CFTR_MUNRE;  Q07E16, CFTR_MUSPF;  Q07DX5, CFTR_NOMLE;  
Q07DZ6, CFTR_ORNAN;  Q2QLH0, CFTR_OTOGA;  Q2QLE5, CFTR_PANTR;  
Q9TSP5, CFTR_PAPAN;  Q6PQZ2, CFTR_PIG;  Q2QLB4, CFTR_PLEMO;  
Q2IBE4, CFTR_PONAB;  Q00554, CFTR_RABIT;  P34158, CFTR_RAT;  
Q2IBB3, CFTR_RHIFE;  Q09YH0, CFTR_SAIBB;  Q00555, CFTR_SHEEP;  
P26362, CFTR_SQUAC;  Q5D1Z7, CFTR_TRIVU;  P26363, CFTR_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.1.-
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