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ENZYME

ENZYME entry: EC 5.6.1.6

PURL: https://purl.expasy.org/enzyme/EC/5.6.1.6
Accepted Name
channel-conductance-controlling ATPase
Alternative Name(s)
CFTR
cystic-fibrosis membrane-conductance-regulating protein
Reaction catalysed
ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Comment(s)
  • ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains.
  • The enzyme is found in animals, and in humans its absence brings about cystic fibrosis.
  • Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis.
  • Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains.
  • The enzyme is also involved in the functioning of other transmembrane channels.
  • Formerly EC 3.6.3.49.
Cross-references
BRENDA5.6.1.6
EC2PDB5.6.1.6
ExplorEnz5.6.1.6
KEGG Ligand Database for Enzyme Nomenclature5.6.1.6
IUBMB Enzyme Nomenclature5.6.1.6
MEDLINEFind literature relating to 5.6.1.6
MetaCyc5.6.1.6
Rhea expert-curated reactions5.6.1.6
UniProtKB/Swiss-Prot
Q07DV2, CFTR_AOTNAQ00PJ2, CFTR_ATEABQ09YK5, CFTR_ATEGE
P35071, CFTR_BOVINQ2QLF9, CFTR_CALJAQ5U820, CFTR_CANLF
Q2QLC5, CFTR_CARPSQ00552, CFTR_CAVPOQ2IBA1, CFTR_CHLAE
Q07DY5, CFTR_COLGUQ1LX78, CFTR_DANREQ07E42, CFTR_DASNO
Q2QL74, CFTR_DIDVIQ2IBF6, CFTR_GORGOQ2QLA3, CFTR_HORSE
P13569, CFTR_HUMANQ108U0, CFTR_LOXAFQ7JII8, CFTR_MACFA
Q7JII7, CFTR_MACFUQ00553, CFTR_MACMUQ9TUQ2, CFTR_MACNE
Q2QL83, CFTR_MICMUP26361, CFTR_MOUSEQ09YJ4, CFTR_MUNMU
Q07DW5, CFTR_MUNREQ07E16, CFTR_MUSPFQ07DX5, CFTR_NOMLE
Q07DZ6, CFTR_ORNANQ2QLH0, CFTR_OTOGAQ2QLE5, CFTR_PANTR
Q9TSP5, CFTR_PAPANQ6PQZ2, CFTR_PIGQ2QLB4, CFTR_PLEMO
Q2IBE4, CFTR_PONABQ00554, CFTR_RABITP34158, CFTR_RAT
Q2IBB3, CFTR_RHIFEQ09YH0, CFTR_SAIBBQ00555, CFTR_SHEEP
P26362, CFTR_SQUACQ5D1Z7, CFTR_TRIVUP26363, CFTR_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-