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ENZYME

ENZYME entry: EC 5.6.2.3

Accepted Name
DNA 5'-3' helicase
Alternative Name(s)
5' to 3' DNA helicase
replication fork helicase
replicative DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand
Comment(s)
  • The activity is stimulated by DNA polymerase III.
  • As the lagging ssDNA is created, it becomes coated with S Single- Stranded DNA Binding protein (SSB).
  • Once every 500-2000 nucleotides, primase is stimulated by DnaB helicase to synthesize a primer at the replication fork.
  • This primer is elongated by the lagging strand half of DNA polymerase III holoenzyme.
Cross-references
BRENDA5.6.2.3
EC2PDB5.6.2.3
ExplorEnz5.6.2.3
PRIAM enzyme-specific profiles5.6.2.3
KEGG Ligand Database for Enzyme Nomenclature5.6.2.3
IUBMB Enzyme Nomenclature5.6.2.3
IntEnz5.6.2.3
MEDLINEFind literature relating to 5.6.2.3
MetaCyc5.6.2.3
Rhea expert-curated reactions5.6.2.3
UniProtKB/Swiss-Prot
A1CJ34, CHL1_ASPCLQ4WWE9, CHL1_ASPFUA2QY22, CHL1_ASPNC
Q2U587, CHL1_ASPORQ21489, CHL1_CAEELQ5AD67, CHL1_CANAL
Q6FKT4, CHL1_CANGAQ1E5T3, CHL1_COCIMQ6BZD9, CHL1_DEBHA
Q750G3, CHL1_EREGSQ6CIF0, CHL1_KLULAA5DUW8, CHL1_LODEL
A1D8E4, CHL1_NEOFIA7UXD4, CHL1_NEUCRA5DNW6, CHL1_PICGU
A3LN13, CHL1_PICSTO14147, CHL1_SCHPOA7ERG1, CHL1_SCLS1
A7TTL0, CHL1_VANPOQ6CAX3, CHL1_YARLIA6ZWN8, CHL1_YEAS7
P22516, CHL1_YEASTF1R345, DDX11_DANREQ96FC9, DDX11_HUMAN
Q6AXC6, DDX11_MOUSEQ8X7X9, DING_ECO57Q8FJN1, DING_ECOL6
P27296, DING_ECOLIP64315, DING_MYCBOA5U229, DING_MYCTA
P9WMR4, DING_MYCTOP9WMR5, DING_MYCTUP29741, DING_PHOPR
Q57RD7, DING_SALCHQ5PG19, DING_SALPAQ8ZQN7, DING_SALTY
Q83LU7, DING_SHIFLP57611, DNAB_BUCAIQ8K932, DNAB_BUCAP
Q89A52, DNAB_BUCBPQ8X5V3, DNAB_ECO57Q8FB22, DNAB_ECOL6
P0ACB0, DNAB_ECOLIQ9X4C9, DNAB_GEOSEO78411, DNAB_GUITH
P45256, DNAB_HAEINQ9ZJM5, DNAB_HELPJO25916, DNAB_HELPY
Q6ABX1, DNAB_LEIXXP59966, DNAB_MYCBOP47340, DNAB_MYCGE
Q9F5P4, DNAB_MYCITP46394, DNAB_MYCLEP75539, DNAB_MYCPN
P9WMR2, DNAB_MYCTOP9WMR3, DNAB_MYCTUQ1XDF3, DNAB_NEOYE
Q8YZA1, DNAB_NOSS1Q9CNL6, DNAB_PASMUP51333, DNAB_PORPU
O30477, DNAB_RHOMRQ1RI04, DNAB_RICBRQ92HG8, DNAB_RICCN
Q4UL62, DNAB_RICFEQ9ZD08, DNAB_RICPRQ68WJ2, DNAB_RICTY
P0A1Q5, DNAB_SALTIP0A1Q4, DNAB_SALTYP0ACB1, DNAB_SHIFL
Q55418, DNAB_SYNY3O83097, DNAB_TREPAP49519, DNAB_TRICV
P37469, DNAC_BACSUQ8W4M7, ERCC2_ARATHA6QLJ0, ERCC2_BOVIN
Q60452, ERCC2_CRIGRQ55G81, ERCC2_DICDIP18074, ERCC2_HUMAN
O08811, ERCC2_MOUSEQ3YK19, FANCJ_CHICKQ9BX63, FANCJ_HUMAN
Q5SXJ3, FANCJ_MOUSEA0A8J1M587, FANCJ_XENLAQ46437, GP1D_CHLMU
Q46259, GP1D_CHLPSB0BCM3, GP1D_CHLT2P0CE16, GP1D_CHLTH
F0NDL2, HELS_SULIRQ974S1, HELS_SULTOQ5ZIW1, PEO1_CHICK
Q9VL76, PEO1_DROMEQ96RR1, PEO1_HUMANQ8CIW5, PEO1_MOUSE
P26659, RAD15_SCHPOP06839, RAD3_YEASTO34481, RECD2_BACSU
Q9RT63, RECD2_DEIRAP57530, RECD_BUCAIQ8K9A8, RECD_BUCAP
Q89AB2, RECD_BUCBPP04993, RECD_ECOLIP45158, RECD_HAEIN
A0QS28, RECD_MYCS2P9WHJ0, RECD_MYCTOP9WHJ1, RECD_MYCTU
P03006, VG12_BPP22Q4JC68, XPD_SULACQ9HM14, XPD_THEAC
Q58352, Y942_METJAP76257, YOAA_ECOLIP44680, YOAA_HAEIN
P50831, YPVA_BACSUQ86YA3, ZGRF1_HUMANQ0VGT4, ZGRF1_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
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