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ENZYME

ENZYME entry: EC 5.6.2.3

PURL: https://purl.expasy.org/enzyme/EC/5.6.2.3
Accepted Name
DNA 5'-3' helicase
Alternative Name(s)
5' to 3' DNA helicase
replication fork helicase
replicative DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction
Comment(s)
  • Helicases are motor proteins that can transiently catalyze the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy.
  • DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation.
  • The best studied DNA 5'-3' helicases are those associated with replication of the chromosome.
  • The activity of the prokaryotic replicative helicase (DnaB) is often stimulated by DNA polymerase III.
  • As the lagging ssDNA is created, it becomes coated with single- stranded DNA binding protein (SSB).
  • Once every 500-2000 nucleotides, primase is stimulated by DnaB helicase to synthesize a primer at the replication fork.
  • This primer is elongated by the lagging strand half of DNA polymerase III holoenzyme.
Cross-references
BRENDA5.6.2.3
EC2PDB5.6.2.3
ExplorEnz5.6.2.3
KEGG Ligand Database for Enzyme Nomenclature5.6.2.3
IUBMB Enzyme Nomenclature5.6.2.3
MEDLINEFind literature relating to 5.6.2.3
MetaCyc5.6.2.3
Rhea expert-curated reactions5.6.2.3
UniProtKB/Swiss-Prot
A1CJ34, CHL1_ASPCLQ4WWE9, CHL1_ASPFUA2QY22, CHL1_ASPNC
Q2U587, CHL1_ASPORQ21489, CHL1_CAEELQ5AD67, CHL1_CANAL
Q6FKT4, CHL1_CANGAQ1E5T3, CHL1_COCIMQ6BZD9, CHL1_DEBHA
Q750G3, CHL1_EREGSQ6CIF0, CHL1_KLULAA5DUW8, CHL1_LODEL
A1D8E4, CHL1_NEOFIA7UXD4, CHL1_NEUCRA5DNW6, CHL1_PICGU
A3LN13, CHL1_PICSTO14147, CHL1_SCHPOA7ERG1, CHL1_SCLS1
A7TTL0, CHL1_VANPOQ6CAX3, CHL1_YARLIA6ZWN8, CHL1_YEAS7
P22516, CHL1_YEASTP32270, DDA_BPT4F1R345, DDX11_DANRE
Q96FC9, DDX11_HUMANQ6AXC6, DDX11_MOUSEQ8X7X9, DING_ECO57
Q8FJN1, DING_ECOL6P27296, DING_ECOLIP64315, DING_MYCBO
A5U229, DING_MYCTAP9WMR4, DING_MYCTOP9WMR5, DING_MYCTU
P29741, DING_PHOPRQ57RD7, DING_SALCHQ5PG19, DING_SALPA
Q8ZQN7, DING_SALTYQ83LU7, DING_SHIFLQ9URU2, DNA2_SCHPO
P38859, DNA2_YEASTP57611, DNAB_BUCAIQ8K932, DNAB_BUCAP
Q89A52, DNAB_BUCBPQ8X5V3, DNAB_ECO57Q8FB22, DNAB_ECOL6
P0ACB0, DNAB_ECOLIQ9X4C9, DNAB_GEOSEO78411, DNAB_GUITH
P45256, DNAB_HAEINQ9ZJM5, DNAB_HELPJO25916, DNAB_HELPY
Q6ABX1, DNAB_LEIXXP59966, DNAB_MYCBOP47340, DNAB_MYCGE
Q9F5P4, DNAB_MYCITP46394, DNAB_MYCLEP75539, DNAB_MYCPN
P9WMR2, DNAB_MYCTOP9WMR3, DNAB_MYCTUQ8YZA1, DNAB_NOSS1
Q9CNL6, DNAB_PASMUP51333, DNAB_PORPUQ1XDF3, DNAB_PYRYE
O30477, DNAB_RHOMRQ1RI04, DNAB_RICBRQ92HG8, DNAB_RICCN
Q4UL62, DNAB_RICFEQ9ZD08, DNAB_RICPRQ68WJ2, DNAB_RICTY
P0A1Q5, DNAB_SALTIP0A1Q4, DNAB_SALTYP0ACB1, DNAB_SHIFL
Q55418, DNAB_SYNY3O83097, DNAB_TREPAP49519, DNAB_TRICV
P37469, DNAC_BACSUQ8W4M7, ERCC2_ARATHA6QLJ0, ERCC2_BOVIN
Q60452, ERCC2_CRIGRQ55G81, ERCC2_DICDIP18074, ERCC2_HUMAN
O08811, ERCC2_MOUSEQ3YK19, FANCJ_CHICKQ9BX63, FANCJ_HUMAN
Q5SXJ3, FANCJ_MOUSEA0A8J1M587, FANCJ_XENLAQ46437, GP1D_CHLMU
Q46259, GP1D_CHLPSB0BCM3, GP1D_CHLT2P0CE16, GP1D_CHLTH
P20315, HELIC_BPT3P03692, HELIC_BPT7F0NDL2, HELS_SACI5
Q974S1, HELS_SULTOQ58824, HERA_METJAQ8U1P0, HERA_PYRFU
Q97WG8, HERA_SACS2F2Z5Z6, HERA_SULACQ96YR7, HERA_SULTO
A0A0H3DK98, PCRAS_MYCPBP75438, PCRAS_MYCPNP47486, PCRA_MYCGE
P75437, PCRA_MYCPNQ5ZIW1, PEO1_CHICKQ9VL76, PEO1_DROME
Q96RR1, PEO1_HUMANQ8CIW5, PEO1_MOUSEQ6MHJ5, PIF1_BDEBA
Q0P9V4, PIF1_CAMJEQ59RQ0, PIF1_CANALQ7ZV90, PIF1_DANRE
Q5AXT5, PIF1_EMENIQ9H611, PIF1_HUMANQ80SX8, PIF1_MOUSE
A5WFR0, PIF1_PSYWFQ1HG60, PIF1_RATQ9UUA2, PIF1_SCHPO
Q384Y1, PIF1_TRYB2Q0R4F1, PIF1_XENLAA6ZM04, PIF1_YEAS7
P07271, PIF1_YEASTQ384Y0, PIF2_TRYB2Q383A1, PIF3_TRYB2
Q381V6, PIF4_TRYB2Q580X6, PIF5_TRYB2Q38CE9, PIF6_TRYB2
Q57YG0, PIF7_TRYB2Q8ILY1, PREX_PLAF7P26659, RAD15_SCHPO
P06839, RAD3_YEASTO34481, RECD2_BACSUQ9RT63, RECD2_DEIRA
P57530, RECD_BUCAIQ8K9A8, RECD_BUCAPQ89AB2, RECD_BUCBP
P04993, RECD_ECOLIP45158, RECD_HAEINA0QS28, RECD_MYCS2
P9WHJ0, RECD_MYCTOP9WHJ1, RECD_MYCTUP9WMQ7, RECG_MYCTU
P38766, RRM3_YEASTP14565, TRAI1_ECOLIP22706, TRAI2_ECOLX
Q6TDU5, TRAI3_ECOLXB5X582, TWIH_ARATHP03006, VG12_BPP22
Q4JC68, XPD_SULACQ9HM14, XPD_THEACQ58960, Y1565_METJA
Q60270, Y3508_METJAQ58352, Y942_METJAP76257, YOAA_ECOLI
P44680, YOAA_HAEINP50831, YPVA_BACSUQ86YA3, ZGRF1_HUMAN
Q0VGT4, ZGRF1_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-