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ENZYME

ENZYME entry: EC 5.6.2.4

Accepted Name
DNA 3'-5' helicase
Alternative Name(s)
Holliday junction DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction
Comment(s)
  • Helicases are motor proteins that can transiently catalyze the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases).
  • DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation.
  • Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind.
  • This entry describes a number of DNA helicases that translocate in the 3'-5' direction.
  • Many of the enzymes require a 3' single-stranded DNA tail.
  • The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram- negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase.
Cross-references
BRENDA5.6.2.4
EC2PDB5.6.2.4
ExplorEnz5.6.2.4
PRIAM enzyme-specific profiles5.6.2.4
KEGG Ligand Database for Enzyme Nomenclature5.6.2.4
IUBMB Enzyme Nomenclature5.6.2.4
IntEnz5.6.2.4
MEDLINEFind literature relating to 5.6.2.4
MetaCyc5.6.2.4
Rhea expert-curated reactions5.6.2.4
UniProtKB/Swiss-Prot
A3DH19, ADDA_ACET2A6TVN2, ADDA_ALKMQA8MJ41, ADDA_ALKOO
B7GM51, ADDA_ANOFWA0RAX7, ADDA_BACAHQ81TW1, ADDA_BACAN
B7JDU4, ADDA_BACC0Q73C23, ADDA_BACC1B7IL84, ADDA_BACC2
B7HGP9, ADDA_BACC4B7HZR5, ADDA_BACC7A7GM37, ADDA_BACCN
B9ITE9, ADDA_BACCQQ81GP9, ADDA_BACCRQ63EM2, ADDA_BACCZ
Q6HM43, ADDA_BACHKQ65LJ9, ADDA_BACLDA9VJ02, ADDA_BACMK
A8FBR1, ADDA_BACP2P23478, ADDA_BACSUA7Z368, ADDA_BACVZ
Q8RCZ0, ADDA_CALS4Q3AA35, ADDA_CARHZQ97GV3, ADDA_CLOAB
A7FPG0, ADDA_CLOB1C3L047, ADDA_CLOB6A6LPC4, ADDA_CLOB8
B2UX57, ADDA_CLOBAB2THC8, ADDA_CLOBBA5HYY0, ADDA_CLOBH
C1FSA8, ADDA_CLOBJB1IEN0, ADDA_CLOBKA7GAJ8, ADDA_CLOBL
B1KUZ8, ADDA_CLOBMQ18AN9, ADDA_CLOD6B9DZK4, ADDA_CLOK1
A5N628, ADDA_CLOK5A0PY67, ADDA_CLONNQ0TV46, ADDA_CLOP1
Q8XPE2, ADDA_CLOPEQ0SWW4, ADDA_CLOPSB1I493, ADDA_DESAP
B8FXD7, ADDA_DESHDQ24WW8, ADDA_DESHYA4J4E3, ADDA_DESRM
Q836J8, ADDA_ENTFAB1YKM8, ADDA_EXIS2Q5L263, ADDA_GEOKA
A4IKW7, ADDA_GEOTNB0TDI0, ADDA_HELMIQ5FJX0, ADDA_LACAC
B3WEJ1, ADDA_LACCBQ1GAA9, ADDA_LACDAQ04AN7, ADDA_LACDB
Q043G6, ADDA_LACGAA8YVK0, ADDA_LACH4Q74JA6, ADDA_LACJO
Q9CJI9, ADDA_LACLAA2RH77, ADDA_LACLMQ033I1, ADDA_LACLS
Q038V7, ADDA_LACP3A9KTE6, ADDA_LACP7Q88U41, ADDA_LACPL
Q38X69, ADDA_LATSSB1MZM2, ADDA_LEUCKQ03W49, ADDA_LEUMM
Q03NA7, ADDA_LEVBAQ1WRS0, ADDA_LIGS1B2GEY4, ADDA_LIMF3
A5VHK2, ADDA_LIMRDB2G532, ADDA_LIMRJQ929A9, ADDA_LISIN
Q71X99, ADDA_LISMFB8DF44, ADDA_LISMHQ8Y511, ADDA_LISMO
A0AL18, ADDA_LISW6B1HN90, ADDA_LYSSCQ2RL77, ADDA_MOOTA
B2A610, ADDA_NATTJQ8ERW5, ADDA_OCEIHQ04GY7, ADDA_OENOB
Q03D71, ADDA_PEDPAA5D1P3, ADDA_PELTSB8I2Y2, ADDA_RUMCH
A7X0I2, ADDA_STAA1A6U074, ADDA_STAA2Q2FIA8, ADDA_STAA3
Q2FZT5, ADDA_STAA8A5IRE5, ADDA_STAA9Q2YWW4, ADDA_STAAB
Q5HHB7, ADDA_STAACA6QFH8, ADDA_STAAEQ99VC3, ADDA_STAAM
Q7A6H4, ADDA_STAANQ6GIC1, ADDA_STAARQ6GAV9, ADDA_STAAS
A8Z073, ADDA_STAATQ8NXE9, ADDA_STAAWB9DIS2, ADDA_STACT
Q5HQJ4, ADDA_STAEQQ8CPT9, ADDA_STAESQ4L4Y3, ADDA_STAHJ
Q49WA6, ADDA_STAS1Q3K1I4, ADDA_STRA1Q8E5T9, ADDA_STRA3
Q8E061, ADDA_STRA5B4U2H1, ADDA_STREMA8AY33, ADDA_STRGC
Q8DT76, ADDA_STRMUQ9A0H3, ADDA_STRP1Q04KF8, ADDA_STRP2
P0CZ52, ADDA_STRP3B5E4P5, ADDA_STRP4Q5XCW6, ADDA_STRP6
Q8P1J2, ADDA_STRP8Q1JCJ8, ADDA_STRPBQ1JMH5, ADDA_STRPC
Q1JHM1, ADDA_STRPDQ1J7E4, ADDA_STRPFA2RFA8, ADDA_STRPG
B1IBR6, ADDA_STRPIB8ZQ32, ADDA_STRPJQ48UB8, ADDA_STRPM
Q97QP9, ADDA_STRPNP0CZ53, ADDA_STRPQB2IPX3, ADDA_STRPS
B5XKR4, ADDA_STRPZQ8DPR6, ADDA_STRR6A4W0M7, ADDA_STRS2
C0MGY6, ADDA_STRS7A3CNT9, ADDA_STRSVA4VUD2, ADDA_STRSY
Q5LY80, ADDA_STRT1Q5M2T7, ADDA_STRT2Q03IZ8, ADDA_STRTD
B9DRV0, ADDA_STRU0Q67MD5, ADDA_SYMTHQ0AXU8, ADDA_SYNWW
B0KDB7, ADDA_THEP3B0K213, ADDA_THEPXA3DH20, ADDB_ACET2
A6TVN9, ADDB_ALKMQA8MJ51, ADDB_ALKOOB7GM52, ADDB_ANOFW
A0RAX6, ADDB_BACAHQ81TW2, ADDB_BACANB7JDU3, ADDB_BACC0
Q73C24, ADDB_BACC1B7IL83, ADDB_BACC2B7HGP8, ADDB_BACC4
B7HZR4, ADDB_BACC7A7GM36, ADDB_BACCNB9ITE8, ADDB_BACCQ
Q81GQ0, ADDB_BACCRQ63EM3, ADDB_BACCZQ6HM44, ADDB_BACHK
Q65LK0, ADDB_BACLDA9VJ01, ADDB_BACMKA8FBR0, ADDB_BACP2
P23477, ADDB_BACSUA7Z367, ADDB_BACVZA6LPC3, ADDB_CLOB8
B2UX56, ADDB_CLOBAB2THC7, ADDB_CLOBBB1I494, ADDB_DESAP
B8FXD8, ADDB_DESHDQ24WW7, ADDB_DESHYA4J4E2, ADDB_DESRM
B1YKM7, ADDB_EXIS2Q5L264, ADDB_GEOKAA4IKW6, ADDB_GEOTN
B0TDI1, ADDB_HELMIQ929A8, ADDB_LISINQ71X98, ADDB_LISMF
B8DF43, ADDB_LISMHQ8Y510, ADDB_LISMOA0AL19, ADDB_LISW6
B1HN89, ADDB_LYSSCQ2RL78, ADDB_MOOTAB2A611, ADDB_NATTJ
Q8ERW6, ADDB_OCEIHA5D1P4, ADDB_PELTSB8I2Y3, ADDB_RUMCH
A7X0I1, ADDB_STAA1A6U073, ADDB_STAA2Q2FIA9, ADDB_STAA3
Q2FZT6, ADDB_STAA8A5IRE4, ADDB_STAA9Q2YWU2, ADDB_STAAB
Q5HHB8, ADDB_STAACA6QFH7, ADDB_STAAEQ99VC4, ADDB_STAAM
Q7A6H5, ADDB_STAANQ6GIC2, ADDB_STAARQ6GAW0, ADDB_STAAS
A8Z072, ADDB_STAATQ8NXF0, ADDB_STAAWB9DIT7, ADDB_STACT
Q5HQJ5, ADDB_STAEQQ8CPU0, ADDB_STAESQ4L4Y2, ADDB_STAHJ
Q49WA5, ADDB_STAS1Q67MD4, ADDB_SYMTHF1ND48, FBH1_CHICK
Q8NFZ0, FBH1_HUMANQ8K2I9, FBH1_MOUSEQ9USU3, FBH1_SCHPO
P15038, HELD_ECOLIQ12039, HMI1_YEASTO34580, PCRA_BACSU
P56255, PCRA_GEOSEQ9S3Q0, PCRA_LEUCIQ53727, PCRA_STAA8
Q5HEL7, PCRA_STAACP64318, PCRA_STAAMP64319, PCRA_STAAN
Q6GFF2, PCRA_STAARQ6G828, PCRA_STAASQ8NVT1, PCRA_STAAW
Q5HN29, PCRA_STAEQQ8CRT9, PCRA_STAESP57654, REP_BUCAI
O51889, REP_BUCAPQ89A21, REP_BUCBPP09980, REP_ECOLI
P44804, REP_HAEINQ9L6S1, REP_SALTYD1KF50, SRS2L_ARATH
Q10213, SRS2_SCHPOP12954, SRS2_YEASTP0A5A4, UVRD1_MYCBO
Q9CD72, UVRD1_MYCLEP9WMQ0, UVRD1_MYCTOP9WMQ1, UVRD1_MYCTU
P64321, UVRD2_MYCBOP53528, UVRD2_MYCLEP9WMP8, UVRD2_MYCTO
P9WMP9, UVRD2_MYCTUP03018, UVRD_ECOLIQ02322, UVRD_HAEIN
P45612, UVRD_MYCCTP47486, UVRD_MYCGEP75437, UVRD_MYCPN
Q1RIP8, UVRD_RICBRQ92HZ6, UVRD_RICCNQ4ULN5, UVRD_RICFE
Q9ZD95, UVRD_RICPRQ68WT1, UVRD_RICTYQ05311, UVRD_SALTY
P75438, Y340_MYCPNO31626, YJCD_BACSUQ5UR49, YR568_MIMIV

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-