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ENZYME

ENZYME entry: EC 5.6.2.4

Accepted Name
DNA 3'-5' helicase
Alternative Name(s)
Holliday junction DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction
Comment(s)
  • Helicases are motor proteins that can transiently catalyze the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases).
  • DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation.
  • Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind.
  • This entry describes a number of DNA helicases that translocate in the 3'-5' direction.
  • Many of the enzymes require a 3' single-stranded DNA tail.
  • The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram- negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase.
Cross-references
BRENDA5.6.2.4
EC2PDB5.6.2.4
ExplorEnz5.6.2.4
KEGG Ligand Database for Enzyme Nomenclature5.6.2.4
IUBMB Enzyme Nomenclature5.6.2.4
MEDLINEFind literature relating to 5.6.2.4
MetaCyc5.6.2.4
Rhea expert-curated reactions5.6.2.4
UniProtKB/Swiss-Prot
A3DH19, ADDA_ACET2A6TVN2, ADDA_ALKMQA8MJ41, ADDA_ALKOO
B7GM51, ADDA_ANOFWA0RAX7, ADDA_BACAHQ81TW1, ADDA_BACAN
B7JDU4, ADDA_BACC0Q73C23, ADDA_BACC1B7IL84, ADDA_BACC2
B7HGP9, ADDA_BACC4B7HZR5, ADDA_BACC7A7GM37, ADDA_BACCN
B9ITE9, ADDA_BACCQQ81GP9, ADDA_BACCRQ63EM2, ADDA_BACCZ
Q6HM43, ADDA_BACHKQ65LJ9, ADDA_BACLDA9VJ02, ADDA_BACMK
A8FBR1, ADDA_BACP2P23478, ADDA_BACSUA7Z368, ADDA_BACVZ
Q8RCZ0, ADDA_CALS4Q3AA35, ADDA_CARHZQ97GV3, ADDA_CLOAB
A7FPG0, ADDA_CLOB1C3L047, ADDA_CLOB6A6LPC4, ADDA_CLOB8
B2UX57, ADDA_CLOBAB2THC8, ADDA_CLOBBA5HYY0, ADDA_CLOBH
C1FSA8, ADDA_CLOBJB1IEN0, ADDA_CLOBKA7GAJ8, ADDA_CLOBL
B1KUZ8, ADDA_CLOBMQ18AN9, ADDA_CLOD6B9DZK4, ADDA_CLOK1
A5N628, ADDA_CLOK5A0PY67, ADDA_CLONNQ0TV46, ADDA_CLOP1
Q8XPE2, ADDA_CLOPEQ0SWW4, ADDA_CLOPSB1I493, ADDA_DESAP
B8FXD7, ADDA_DESHDQ24WW8, ADDA_DESHYA4J4E3, ADDA_DESRM
Q836J8, ADDA_ENTFAB1YKM8, ADDA_EXIS2Q5L263, ADDA_GEOKA
A4IKW7, ADDA_GEOTNB0TDI0, ADDA_HELMIQ5FJX0, ADDA_LACAC
B3WEJ1, ADDA_LACCBQ1GAA9, ADDA_LACDAQ04AN7, ADDA_LACDB
Q043G6, ADDA_LACGAA8YVK0, ADDA_LACH4Q74JA6, ADDA_LACJO
Q9CJI9, ADDA_LACLAA2RH77, ADDA_LACLMQ033I1, ADDA_LACLS
Q038V7, ADDA_LACP3A9KTE6, ADDA_LACP7Q88U41, ADDA_LACPL
Q38X69, ADDA_LATSSB1MZM2, ADDA_LEUCKQ03W49, ADDA_LEUMM
Q03NA7, ADDA_LEVBAQ1WRS0, ADDA_LIGS1B2GEY4, ADDA_LIMF3
A5VHK2, ADDA_LIMRDB2G532, ADDA_LIMRJQ929A9, ADDA_LISIN
Q71X99, ADDA_LISMFB8DF44, ADDA_LISMHQ8Y511, ADDA_LISMO
A0AL18, ADDA_LISW6B1HN90, ADDA_LYSSCQ2RL77, ADDA_MOOTA
B2A610, ADDA_NATTJQ8ERW5, ADDA_OCEIHQ04GY7, ADDA_OENOB
Q03D71, ADDA_PEDPAA5D1P3, ADDA_PELTSB8I2Y2, ADDA_RUMCH
A7X0I2, ADDA_STAA1A6U074, ADDA_STAA2Q2FIA8, ADDA_STAA3
Q2FZT5, ADDA_STAA8A5IRE5, ADDA_STAA9Q2YWW4, ADDA_STAAB
Q5HHB7, ADDA_STAACA6QFH8, ADDA_STAAEQ99VC3, ADDA_STAAM
Q7A6H4, ADDA_STAANQ6GIC1, ADDA_STAARQ6GAV9, ADDA_STAAS
A8Z073, ADDA_STAATQ8NXE9, ADDA_STAAWB9DIS2, ADDA_STACT
Q5HQJ4, ADDA_STAEQQ8CPT9, ADDA_STAESQ4L4Y3, ADDA_STAHJ
Q49WA6, ADDA_STAS1Q3K1I4, ADDA_STRA1Q8E5T9, ADDA_STRA3
Q8E061, ADDA_STRA5B4U2H1, ADDA_STREMA8AY33, ADDA_STRGC
Q8DT76, ADDA_STRMUQ9A0H3, ADDA_STRP1Q04KF8, ADDA_STRP2
P0CZ52, ADDA_STRP3B5E4P5, ADDA_STRP4Q5XCW6, ADDA_STRP6
Q8P1J2, ADDA_STRP8Q1JCJ8, ADDA_STRPBQ1JMH5, ADDA_STRPC
Q1JHM1, ADDA_STRPDQ1J7E4, ADDA_STRPFA2RFA8, ADDA_STRPG
B1IBR6, ADDA_STRPIB8ZQ32, ADDA_STRPJQ48UB8, ADDA_STRPM
Q97QP9, ADDA_STRPNP0CZ53, ADDA_STRPQB2IPX3, ADDA_STRPS
B5XKR4, ADDA_STRPZQ8DPR6, ADDA_STRR6A4W0M7, ADDA_STRS2
C0MGY6, ADDA_STRS7A3CNT9, ADDA_STRSVA4VUD2, ADDA_STRSY
Q5LY80, ADDA_STRT1Q5M2T7, ADDA_STRT2Q03IZ8, ADDA_STRTD
B9DRV0, ADDA_STRU0Q67MD5, ADDA_SYMTHQ0AXU8, ADDA_SYNWW
B0KDB7, ADDA_THEP3B0K213, ADDA_THEPXO18017, BLM_CAEEL
Q9I920, BLM_CHICKQ9VGI8, BLM_DROMEP54132, BLM_HUMAN
O88700, BLM_MOUSEQ9DEY9, BLM_XENLAQ1RMT1, ERCC3_BOVIN
Q5ZKK7, ERCC3_CHICKQ7ZVV1, ERCC3_DANREO00835, ERCC3_DICDI
Q02870, ERCC3_DROMEP19447, ERCC3_HUMANQ60HG1, ERCC3_MACFA
P49135, ERCC3_MOUSEQ5RA62, ERCC3_PONABQ4G005, ERCC3_RAT
O13768, ERCC3_SCHPOQ9VDA0, FANCM_DROMEF1ND48, FBH1_CHICK
Q8NFZ0, FBH1_HUMANQ8K2I9, FBH1_MOUSEQ9USU3, FBH1_SCHPO
P15038, HELD_ECOLIQ9YFQ8, HELS_AERPEP0DMI1, HELS_ARCFU
A8MB76, HELS_CALMQQ5UYM9, HELS_HALMAB0R7Q2, HELS_HALS3
Q9HMV6, HELS_HALSAQ8TL39, HELS_METACQ0W6L1, HELS_METAR
A7IB61, HELS_METB6Q465R3, HELS_METBFQ12WZ6, HELS_METBU
Q58524, HELS_METJAQ8PZR7, HELS_METMAO26901, HELS_METTH
A6UN73, HELS_METVSQ3IU46, HELS_NATPDQ9V0A9, HELS_PYRAB
A3MSA1, HELS_PYRCJO73946, HELS_PYRFUO59025, HELS_PYRHO
Q97VY9, HELS_SACS2D0KN27, HELS_SACS9Q4JC00, HELS_SULAC
F0NDL2, HELS_SULIRQ974S1, HELS_SULTOQ9HJX7, HELS_THEAC
Q5JGV6, HELS_THEKOQ97AI2, HELS_THEVOQ12039, HMI1_YEAST
Q09811, HUS2_SCHPOP13894, LT_BFPYVP14999, LT_POVBA
P0DOJ4, LT_POVBGP03071, LT_POVBKP24851, LT_POVBO
P03075, LT_POVHAP03072, LT_POVJCP0DOI7, LT_POVK3
P0DOI6, LT_POVK6P0DOI5, LT_POVKIP04008, LT_POVLY
P0DOJ6, LT_POVM1P0DOJ5, LT_POVM3P03073, LT_POVMA
P12905, LT_POVMCP24597, LT_POVMKQ3L6L5, LT_POVS1
A8Y984, LT_POVSMA5HBG1, LT_POVWUP03070, LT_SV40
O34580, PCRA_BACSUP56255, PCRA_GEOSEQ9S3Q0, PCRA_LEUCI
Q53727, PCRA_STAA8Q5HEL7, PCRA_STAACP64318, PCRA_STAAM
P64319, PCRA_STAANQ6GFF2, PCRA_STAARQ6G828, PCRA_STAAS
Q8NVT1, PCRA_STAAWQ5HN29, PCRA_STAEQQ8CRT9, PCRA_STAES
Q6E6J3, RAD25_ANTLOQ8SSK1, RAD25_ENCCUA9CRJ7, RAD25_ENTBH
Q5V5F7, RAD25_HALMAQ9HPZ2, RAD25_HALSAC4V922, RAD25_VAIC1
Q00578, RAD25_YEASTO51578, RECB_BORBUP57529, RECB_BUCAI
Q8K9A9, RECB_BUCAPQ89AB3, RECB_BUCBPQ9PLT8, RECB_CHLMU
Q9Z7G7, RECB_CHLPNO84645, RECB_CHLTRP08394, RECB_ECOLI
P45157, RECB_HAEINA0QS29, RECB_MYCS2P9WMQ2, RECB_MYCTO
P9WMQ3, RECB_MYCTUO50224, RECG_ACIFIO67837, RECG_AQUAE
F4INA9, RECG_ARATHO34942, RECG_BACSUO51528, RECG_BORBU
B7UM74, RECG_ECO27Q8XD86, RECG_ECO57P24230, RECG_ECOLI
P43809, RECG_HAEINQ9ZJA1, RECG_HELPJO26051, RECG_HELPY
P64323, RECG_MYCBOO69460, RECG_MYCLEP9WMQ6, RECG_MYCTO
P9WMQ7, RECG_MYCTUQ9CMB4, RECG_PASMUO50581, RECG_STAA8
Q5HGK6, RECG_STAACP64324, RECG_STAAMP64325, RECG_STAAN
Q6GHK8, RECG_STAARQ6G9Y6, RECG_STAASQ8NX11, RECG_STAAW
Q5HPW4, RECG_STAEQQ8CSV3, RECG_STAESQ54900, RECG_STRPN
Q55681, RECG_SYNY3Q9WY48, RECG_THEMAP96130, RECG_TREPA
A8WK63, RECQ1_CAEBRQ9TXJ8, RECQ1_CAEELP46063, RECQ1_HUMAN
Q9Z129, RECQ1_MOUSEQ5RF63, RECQ1_PONABQ6AYJ1, RECQ1_RAT
Q9FT73, RECQ2_ARATHO94761, RECQ4_HUMANQ75NR7, RECQ4_MOUSE
O94762, RECQ5_HUMANQ8VID5, RECQ5_MOUSED4ACP5, RECQ5_RAT
O34748, RECQ_BACSUP15043, RECQ_ECOLIP71359, RECQ_HAEIN
Q9CL21, RECQ_PASMUP40724, RECQ_SALTYP73421, RECQ_SYNY3
P50729, RECS_BACSUP57654, REP_BUCAIO51889, REP_BUCAP
Q89A21, REP_BUCBPP09980, REP_ECOLIP44804, REP_HAEIN
Q9L6S1, REP_SALTYQ9FT74, RQL1_ARATHQ9FT72, RQL3_ARATH
Q8L840, RQL4A_ARATHQ9FT70, RQL4B_ARATHQ0WVW7, RQL5_ARATH
Q9FT69, RQSIM_ARATHP35187, SGS1_YEASTD1KF50, SRS2L_ARATH
Q10213, SRS2_SCHPOP12954, SRS2_YEASTP0CT33, TLH1_SCHPO
Q1RKN3, TLH2_SCHPOP0A5A4, UVRD1_MYCBOQ9CD72, UVRD1_MYCLE
P9WMQ0, UVRD1_MYCTOP9WMQ1, UVRD1_MYCTUP64321, UVRD2_MYCBO
P53528, UVRD2_MYCLEP9WMP8, UVRD2_MYCTOP9WMP9, UVRD2_MYCTU
P03018, UVRD_ECOLIQ02322, UVRD_HAEINP45612, UVRD_MYCCT
P47486, UVRD_MYCGEP75437, UVRD_MYCPNQ1RIP8, UVRD_RICBR
Q92HZ6, UVRD_RICCNQ4ULN5, UVRD_RICFEQ9ZD95, UVRD_RICPR
Q68WT1, UVRD_RICTYQ05311, UVRD_SALTYP0DXF1, UVSW_BPT4
Q19546, WRN_CAEELQ14191, WRN_HUMANO09053, WRN_MOUSE
O93530, WRN_XENLAQ38861, XPB1_ARATHQ971U1, XPB1_SULTO
Q9FUG4, XPB2_ARATHQ970I2, XPB2_SULTOQ381F9, XPBR_TRYB2
O29889, XPB_ARCFUA6WE36, XPB_KINRDO53873, XPB_MYCTU
Q580W5, XPB_TRYB2P75438, Y340_MYCPNO31626, YJCD_BACSU
Q5UR49, YR568_MIMIV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-