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ENZYME

ENZYME entry: EC 5.6.2.4

PURL: https://purl.expasy.org/enzyme/EC/5.6.2.4
Accepted Name
DNA 3'-5' helicase
Alternative Name(s)
Holliday junction DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction
Comment(s)
  • Helicases are motor proteins that can transiently catalyze the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases).
  • DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation.
  • Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind.
  • This entry describes a number of DNA helicases that translocate in the 3'-5' direction.
  • Many of the enzymes require a 3' single-stranded DNA tail.
  • The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram- negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase.
Cross-references
BRENDA5.6.2.4
EC2PDB5.6.2.4
ExplorEnz5.6.2.4
KEGG Ligand Database for Enzyme Nomenclature5.6.2.4
IUBMB Enzyme Nomenclature5.6.2.4
MEDLINEFind literature relating to 5.6.2.4
MetaCyc5.6.2.4
Rhea expert-curated reactions5.6.2.4
UniProtKB/Swiss-Prot
A3DH19, ADDA_ACET2A6TVN2, ADDA_ALKMQA8MJ41, ADDA_ALKOO
B7GM51, ADDA_ANOFWA0RAX7, ADDA_BACAHQ81TW1, ADDA_BACAN
B7JDU4, ADDA_BACC0Q73C23, ADDA_BACC1B7IL84, ADDA_BACC2
B7HGP9, ADDA_BACC4B7HZR5, ADDA_BACC7A7GM37, ADDA_BACCN
B9ITE9, ADDA_BACCQQ81GP9, ADDA_BACCRQ63EM2, ADDA_BACCZ
Q6HM43, ADDA_BACHKQ65LJ9, ADDA_BACLDA9VJ02, ADDA_BACMK
A8FBR1, ADDA_BACP2P23478, ADDA_BACSUA7Z368, ADDA_BACVZ
Q8RCZ0, ADDA_CALS4Q3AA35, ADDA_CARHZQ97GV3, ADDA_CLOAB
A7FPG0, ADDA_CLOB1C3L047, ADDA_CLOB6A6LPC4, ADDA_CLOB8
B2UX57, ADDA_CLOBAB2THC8, ADDA_CLOBBA5HYY0, ADDA_CLOBH
C1FSA8, ADDA_CLOBJB1IEN0, ADDA_CLOBKA7GAJ8, ADDA_CLOBL
B1KUZ8, ADDA_CLOBMQ18AN9, ADDA_CLOD6B9DZK4, ADDA_CLOK1
A5N628, ADDA_CLOK5A0PY67, ADDA_CLONNQ0TV46, ADDA_CLOP1
Q8XPE2, ADDA_CLOPEQ0SWW4, ADDA_CLOPSB1I493, ADDA_DESAP
B8FXD7, ADDA_DESHDQ24WW8, ADDA_DESHYA4J4E3, ADDA_DESRM
Q836J8, ADDA_ENTFAB1YKM8, ADDA_EXIS2Q5L263, ADDA_GEOKA
A4IKW7, ADDA_GEOTNB0TDI0, ADDA_HELMIQ5FJX0, ADDA_LACAC
B3WEJ1, ADDA_LACCBQ1GAA9, ADDA_LACDAQ04AN7, ADDA_LACDB
Q043G6, ADDA_LACGAA8YVK0, ADDA_LACH4Q74JA6, ADDA_LACJO
Q9CJI9, ADDA_LACLAA2RH77, ADDA_LACLMQ033I1, ADDA_LACLS
Q038V7, ADDA_LACP3A9KTE6, ADDA_LACP7Q88U41, ADDA_LACPL
Q38X69, ADDA_LATSSB1MZM2, ADDA_LEUCKQ03W49, ADDA_LEUMM
Q03NA7, ADDA_LEVBAQ1WRS0, ADDA_LIGS1B2GEY4, ADDA_LIMF3
A5VHK2, ADDA_LIMRDB2G532, ADDA_LIMRJQ929A9, ADDA_LISIN
Q71X99, ADDA_LISMFB8DF44, ADDA_LISMHQ8Y511, ADDA_LISMO
A0AL18, ADDA_LISW6B1HN90, ADDA_LYSSCQ2RL77, ADDA_MOOTA
B2A610, ADDA_NATTJQ8ERW5, ADDA_OCEIHQ04GY7, ADDA_OENOB
Q03D71, ADDA_PEDPAA5D1P3, ADDA_PELTSB8I2Y2, ADDA_RUMCH
A7X0I2, ADDA_STAA1A6U074, ADDA_STAA2Q2FIA8, ADDA_STAA3
Q2FZT5, ADDA_STAA8A5IRE5, ADDA_STAA9Q2YWW4, ADDA_STAAB
Q5HHB7, ADDA_STAACA6QFH8, ADDA_STAAEQ99VC3, ADDA_STAAM
Q7A6H4, ADDA_STAANQ6GIC1, ADDA_STAARQ6GAV9, ADDA_STAAS
A8Z073, ADDA_STAATQ8NXE9, ADDA_STAAWB9DIS2, ADDA_STACT
Q5HQJ4, ADDA_STAEQQ8CPT9, ADDA_STAESQ4L4Y3, ADDA_STAHJ
Q49WA6, ADDA_STAS1Q3K1I4, ADDA_STRA1Q8E5T9, ADDA_STRA3
Q8E061, ADDA_STRA5B4U2H1, ADDA_STREMA8AY33, ADDA_STRGC
Q8DT76, ADDA_STRMUQ9A0H3, ADDA_STRP1Q04KF8, ADDA_STRP2
P0CZ52, ADDA_STRP3B5E4P5, ADDA_STRP4Q5XCW6, ADDA_STRP6
Q8P1J2, ADDA_STRP8Q1JCJ8, ADDA_STRPBQ1JMH5, ADDA_STRPC
Q1JHM1, ADDA_STRPDQ1J7E4, ADDA_STRPFA2RFA8, ADDA_STRPG
B1IBR6, ADDA_STRPIB8ZQ32, ADDA_STRPJQ48UB8, ADDA_STRPM
Q97QP9, ADDA_STRPNP0CZ53, ADDA_STRPQB2IPX3, ADDA_STRPS
B5XKR4, ADDA_STRPZQ8DPR6, ADDA_STRR6A4W0M7, ADDA_STRS2
C0MGY6, ADDA_STRS7A3CNT9, ADDA_STRSVA4VUD2, ADDA_STRSY
Q5LY80, ADDA_STRT1Q5M2T7, ADDA_STRT2Q03IZ8, ADDA_STRTD
B9DRV0, ADDA_STRU0Q67MD5, ADDA_SYMTHQ0AXU8, ADDA_SYNWW
B0KDB7, ADDA_THEP3B0K213, ADDA_THEPXE1BNG3, ASCC3_BOVIN
F1NTD6, ASCC3_CHICKE7F8F4, ASCC3_DANREQ54G57, ASCC3_DICDI
Q8N3C0, ASCC3_HUMANE9PZJ8, ASCC3_MOUSEF1LPQ2, ASCC3_RAT
O18017, BLM_CAEELQ9I920, BLM_CHICKQ9VGI8, BLM_DROME
P54132, BLM_HUMANO88700, BLM_MOUSEQ9DEY9, BLM_XENLA
Q1RMT1, ERCC3_BOVINQ5ZKK7, ERCC3_CHICKQ7ZVV1, ERCC3_DANRE
O00835, ERCC3_DICDIQ02870, ERCC3_DROMEP19447, ERCC3_HUMAN
Q60HG1, ERCC3_MACFAP49135, ERCC3_MOUSEQ5RA62, ERCC3_PONAB
Q4G005, ERCC3_RATO13768, ERCC3_SCHPOQ9VDA0, FANCM_DROME
F1ND48, FBH1_CHICKQ8NFZ0, FBH1_HUMANQ8K2I9, FBH1_MOUSE
Q9USU3, FBH1_SCHPOP15038, HELD_ECOLIH2KY86, HELQ_CAEEL
Q9VSE2, HELQ_DROMEQ8TDG4, HELQ_HUMANQ2VPA6, HELQ_MOUSE
Q9YFQ8, HELS_AERPEP0DMI1, HELS_ARCFUA8MB76, HELS_CALMQ
Q5UYM9, HELS_HALMAB0R7Q2, HELS_HALS3Q9HMV6, HELS_HALSA
Q8TL39, HELS_METACQ0W6L1, HELS_METARA7IB61, HELS_METB6
Q465R3, HELS_METBFQ12WZ6, HELS_METBUQ58524, HELS_METJA
Q8PZR7, HELS_METMAO26901, HELS_METTHA6UN73, HELS_METVS
Q3IU46, HELS_NATPDQ9V0A9, HELS_PYRABA3MSA1, HELS_PYRCJ
O73946, HELS_PYRFUO59025, HELS_PYRHOF0NDL2, HELS_SACI5
Q97VY9, HELS_SACS2D0KN27, HELS_SACS9Q4JC00, HELS_SULAC
Q974S1, HELS_SULTOQ9HJX7, HELS_THEACQ5JGV6, HELS_THEKO
Q97AI2, HELS_THEVOQ58824, HERA_METJAQ8U1P0, HERA_PYRFU
Q97WG8, HERA_SACS2F2Z5Z6, HERA_SULACQ96YR7, HERA_SULTO
A2PYH4, HFM1_HUMAND3Z4R1, HFM1_MOUSEA2RUV5, HFM1_XENTR
P51979, HFM1_YEASTQ12039, HMI1_YEASTO13983, HRQ1_SCHPO
Q05549, HRQ1_YEASTQ09811, HUS2_SCHPOQ57742, LHRC_METJA
O27830, LHRC_METTHQ88NV1, LHRC_PSEPKP95949, LHRC_SACS2
Q4J8R1, LHRC_SULACP30015, LHR_ECOLIA0QT91, LHR_MYCS2
P13894, LT_BFPYVP14999, LT_POVBAP0DOJ4, LT_POVBG
P03071, LT_POVBKP24851, LT_POVBOP03075, LT_POVHA
P03072, LT_POVJCP0DOI7, LT_POVK3P0DOI6, LT_POVK6
P0DOI5, LT_POVKIP04008, LT_POVLYP0DOJ6, LT_POVM1
P0DOJ5, LT_POVM3P03073, LT_POVMAP12905, LT_POVMC
P24597, LT_POVMKQ3L6L5, LT_POVS1A8Y984, LT_POVSM
A5HBG1, LT_POVWUP03070, LT_SV40Q5D892, MER3_ARATH
B6DMK2, MER3_ORYSJO34580, PCRA_BACSUP56255, PCRA_GEOSE
Q9S3Q0, PCRA_LEUCIQ53727, PCRA_STAA8Q5HEL7, PCRA_STAAC
P64318, PCRA_STAAMP64319, PCRA_STAANQ6GFF2, PCRA_STAAR
Q6G828, PCRA_STAASQ8NVT1, PCRA_STAAWQ5HN29, PCRA_STAEQ
Q8CRT9, PCRA_STAESP94461, PRIA_BACSUQ45032, PRIA_BORBU
P57220, PRIA_BUCAIQ8KA15, PRIA_BUCAPQ9PLE5, PRIA_CHLMU
Q9Z6Y2, PRIA_CHLPNO84783, PRIA_CHLTRP17888, PRIA_ECOLI
P44647, PRIA_HAEINQ9ZKE4, PRIA_HELPJO25149, PRIA_HELPY
A6TGC5, PRIA_KLEP7Q5F6V8, PRIA_NEIG1P05445, PRIA_RHORT
Q1RI08, PRIA_RICBRQ92HH1, PRIA_RICCNQ4UL64, PRIA_RICFE
Q9ZD10, PRIA_RICPRQ68WJ4, PRIA_RICTYP74397, PRIA_SYNY3
Q9WY22, PRIA_THEMAO83258, PRIA_TREPAQ6E6J3, RAD25_ANTLO
Q8SSK1, RAD25_ENCCUA9CRJ7, RAD25_ENTBHQ5V5F7, RAD25_HALMA
Q9HPZ2, RAD25_HALSAC4V922, RAD25_VAIC1Q00578, RAD25_YEAST
O51578, RECB_BORBUP57529, RECB_BUCAIQ8K9A9, RECB_BUCAP
Q89AB3, RECB_BUCBPQ9PLT8, RECB_CHLMUQ9Z7G7, RECB_CHLPN
O84645, RECB_CHLTRP08394, RECB_ECOLIP45157, RECB_HAEIN
A0QS29, RECB_MYCS2P9WMQ2, RECB_MYCTOP9WMQ3, RECB_MYCTU
O50224, RECG_ACIFIO67837, RECG_AQUAEF4INA9, RECG_ARATH
O34942, RECG_BACSUO51528, RECG_BORBUB7UM74, RECG_ECO27
Q8XD86, RECG_ECO57P24230, RECG_ECOLIP43809, RECG_HAEIN
Q9ZJA1, RECG_HELPJO26051, RECG_HELPYP64323, RECG_MYCBO
O69460, RECG_MYCLEP9WMQ6, RECG_MYCTOP9WMQ7, RECG_MYCTU
Q9CMB4, RECG_PASMUO50581, RECG_STAA8Q5HGK6, RECG_STAAC
P64324, RECG_STAAMP64325, RECG_STAANQ6GHK8, RECG_STAAR
Q6G9Y6, RECG_STAASQ8NX11, RECG_STAAWQ5HPW4, RECG_STAEQ
Q8CSV3, RECG_STAESQ54900, RECG_STRPNQ55681, RECG_SYNY3
Q9WY48, RECG_THEMAP96130, RECG_TREPAA8WK63, RECQ1_CAEBR
Q9TXJ8, RECQ1_CAEELP46063, RECQ1_HUMANQ9Z129, RECQ1_MOUSE
Q5RF63, RECQ1_PONABQ6AYJ1, RECQ1_RATQ9FT73, RECQ2_ARATH
O94761, RECQ4_HUMANQ75NR7, RECQ4_MOUSEO94762, RECQ5_HUMAN
Q8VID5, RECQ5_MOUSED4ACP5, RECQ5_RATO34748, RECQ_BACSU
P15043, RECQ_ECOLIP71359, RECQ_HAEINQ9CL21, RECQ_PASMU
P40724, RECQ_SALTYP73421, RECQ_SYNY3P50729, RECS_BACSU
P57654, REP_BUCAIO51889, REP_BUCAPQ89A21, REP_BUCBP
P09980, REP_ECOLIP44804, REP_HAEINQ9L6S1, REP_SALTY
Q9FT74, RQL1_ARATHQ9FT72, RQL3_ARATHQ8L840, RQL4A_ARATH
Q9FT70, RQL4B_ARATHQ0WVW7, RQL5_ARATHQ9FT69, RQSIM_ARATH
P35187, SGS1_YEASTD1KF50, SRS2L_ARATHQ10213, SRS2_SCHPO
P12954, SRS2_YEASTP0CT33, TLH1_SCHPOQ1RKN3, TLH2_SCHPO
P0A5A4, UVRD1_MYCBOQ9CD72, UVRD1_MYCLEP9WMQ0, UVRD1_MYCTO
P9WMQ1, UVRD1_MYCTUP64321, UVRD2_MYCBOP53528, UVRD2_MYCLE
P9WMP8, UVRD2_MYCTOP9WMP9, UVRD2_MYCTUP03018, UVRD_ECOLI
Q02322, UVRD_HAEINP45612, UVRD_MYCCTP47486, UVRD_MYCGE
P75437, UVRD_MYCPNQ1RIP8, UVRD_RICBRQ92HZ6, UVRD_RICCN
Q4ULN5, UVRD_RICFEQ9ZD95, UVRD_RICPRQ68WT1, UVRD_RICTY
Q05311, UVRD_SALTYP0DXF1, UVSW_BPT4P03116, VE1_BPV1
P11298, VE1_BPV2Q8BDD7, VE1_BPV3P08344, VE1_BPV4
Q705G8, VE1_BPV5Q705F4, VE1_BPV6Q89536, VE1_COPV6
P03112, VE1_CRPVKP51894, VE1_CRPVWP06455, VE1_FPVL
P36719, VE1_HPV03Q07846, VE1_HPV04P06920, VE1_HPV05
Q05133, VE1_HPV07P06420, VE1_HPV08Q05111, VE1_HPV09
P03111, VE1_HPV1P36720, VE1_HPV10P04014, VE1_HPV11
Q05134, VE1_HPV12Q02261, VE1_HPV13P36721, VE1_HPV14
Q05135, VE1_HPV15P03114, VE1_HPV16Q02512, VE1_HPV17
P06789, VE1_HPV18Q02048, VE1_HPV19P50758, VE1_HPV20
P50759, VE1_HPV21P50760, VE1_HPV22P50761, VE1_HPV23
P50762, VE1_HPV24Q02049, VE1_HPV25P36722, VE1_HPV26
P36723, VE1_HPV27P50763, VE1_HPV28P50764, VE1_HPV29
P25481, VE1_HPV2AQ05112, VE1_HPV30P17382, VE1_HPV31
P36724, VE1_HPV32P06421, VE1_HPV33P36725, VE1_HPV34
P27220, VE1_HPV35P50808, VE1_HPV36Q80902, VE1_HPV37
Q80909, VE1_HPV38P24829, VE1_HPV39P36727, VE1_HPV40
P27551, VE1_HPV41P27221, VE1_HPV42Q80915, VE1_HPV44
P36728, VE1_HPV45P22419, VE1_HPV47Q80922, VE1_HPV48
P36729, VE1_HPV49P26544, VE1_HPV51P36730, VE1_HPV52
Q02513, VE1_HPV53Q81020, VE1_HPV54P22153, VE1_HPV57
P26543, VE1_HPV58Q81966, VE1_HPV59P26542, VE1_HPV5B
Q80943, VE1_HPV60Q80950, VE1_HPV61Q07847, VE1_HPV63
Q07848, VE1_HPV65Q80957, VE1_HPV66Q9JH49, VE1_HPV69
Q84293, VE1_HPV6AP03113, VE1_HPV6BP50765, VE1_HPV70
Q81999, VE1_HPV72Q82007, VE1_HPV73O40619, VE1_HPVR7
P22154, VE1_MMPV1Q84356, VE1_MNPVAP03117, VE1_OVPVD
P11328, VE1_PAPVEQ02262, VE1_PCPV1P81174, VE1_PCPVC
Q19546, WRN_CAEELQ14191, WRN_HUMANO09053, WRN_MOUSE
O93530, WRN_XENLAQ38861, XPB1_ARATHQ971U1, XPB1_SULTO
Q9FUG4, XPB2_ARATHQ970I2, XPB2_SULTOQ381F9, XPBR_TRYB2
O29889, XPB_ARCFUA6WE36, XPB_KINRDO53873, XPB_MYCTU
Q580W5, XPB_TRYB2Q58960, Y1565_METJAP75438, Y340_MYCPN
Q60270, Y3508_METJAO31626, YJCD_BACSUQ5UR49, YR568_MIMIV

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-