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ENZYME

ENZYME entry: EC 5.6.2.4

PURL: https://purl.expasy.org/enzyme/EC/5.6.2.4
Accepted Name
DNA 3'-5' helicase
Alternative Name(s)
Holliday junction DNA helicase
Reaction catalysed
Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction
Comment(s)
  • Helicases are motor proteins that can transiently catalyze the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases).
  • DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation.
  • Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind.
  • This entry describes a number of DNA helicases that translocate in the 3'-5' direction.
  • Many of the enzymes require a 3' single-stranded DNA tail.
  • The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram- negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase.
Cross-references
Rhea expert-curated reactions5.6.2.4
ExplorEnz5.6.2.4
IUBMB Enzyme Nomenclature5.6.2.4
UniProtKB/Swiss-Prot
A3DH19, ADDA_ACET2A6TVN2, ADDA_ALKMQA8MJ41, ADDA_ALKOO
B7GM51, ADDA_ANOFWA0RAX7, ADDA_BACAHQ81TW1, ADDA_BACAN
B7JDU4, ADDA_BACC0Q73C23, ADDA_BACC1B7IL84, ADDA_BACC2
B7HGP9, ADDA_BACC4B7HZR5, ADDA_BACC7A7GM37, ADDA_BACCN
B9ITE9, ADDA_BACCQQ81GP9, ADDA_BACCRQ63EM2, ADDA_BACCZ
Q6HM43, ADDA_BACHKQ65LJ9, ADDA_BACLDA9VJ02, ADDA_BACMK
A8FBR1, ADDA_BACP2P23478, ADDA_BACSUA7Z368, ADDA_BACVZ
Q8RCZ0, ADDA_CALS4Q3AA35, ADDA_CARHZQ97GV3, ADDA_CLOAB
A7FPG0, ADDA_CLOB1C3L047, ADDA_CLOB6A6LPC4, ADDA_CLOB8
B2UX57, ADDA_CLOBAB2THC8, ADDA_CLOBBA5HYY0, ADDA_CLOBH
C1FSA8, ADDA_CLOBJB1IEN0, ADDA_CLOBKA7GAJ8, ADDA_CLOBL
B1KUZ8, ADDA_CLOBMQ18AN9, ADDA_CLOD6B9DZK4, ADDA_CLOK1
A5N628, ADDA_CLOK5A0PY67, ADDA_CLONNQ0TV46, ADDA_CLOP1
Q8XPE2, ADDA_CLOPEQ0SWW4, ADDA_CLOPSB1I493, ADDA_DESAP
B8FXD7, ADDA_DESHDQ24WW8, ADDA_DESHYA4J4E3, ADDA_DESRM
Q836J8, ADDA_ENTFAB1YKM8, ADDA_EXIS2Q5L263, ADDA_GEOKA
A4IKW7, ADDA_GEOTNB0TDI0, ADDA_HELMIQ5FJX0, ADDA_LACAC
B3WEJ1, ADDA_LACCBQ1GAA9, ADDA_LACDAQ04AN7, ADDA_LACDB
Q043G6, ADDA_LACGAA8YVK0, ADDA_LACH4Q74JA6, ADDA_LACJO
Q9CJI9, ADDA_LACLAA2RH77, ADDA_LACLMQ033I1, ADDA_LACLS
Q038V7, ADDA_LACP3A9KTE6, ADDA_LACP7Q88U41, ADDA_LACPL
Q38X69, ADDA_LATSSB1MZM2, ADDA_LEUCKQ03W49, ADDA_LEUMM
Q03NA7, ADDA_LEVBAQ1WRS0, ADDA_LIGS1B2GEY4, ADDA_LIMF3
A5VHK2, ADDA_LIMRDB2G532, ADDA_LIMRJQ929A9, ADDA_LISIN
Q71X99, ADDA_LISMFB8DF44, ADDA_LISMHQ8Y511, ADDA_LISMO
A0AL18, ADDA_LISW6B1HN90, ADDA_LYSSCQ2RL77, ADDA_MOOTA
B2A610, ADDA_NATTJQ8ERW5, ADDA_OCEIHQ04GY7, ADDA_OENOB
Q03D71, ADDA_PEDPAA5D1P3, ADDA_PELTSB8I2Y2, ADDA_RUMCH
A7X0I2, ADDA_STAA1A6U074, ADDA_STAA2Q2FIA8, ADDA_STAA3
Q2FZT5, ADDA_STAA8A5IRE5, ADDA_STAA9Q2YWW4, ADDA_STAAB
Q5HHB7, ADDA_STAACA6QFH8, ADDA_STAAEQ99VC3, ADDA_STAAM
Q7A6H4, ADDA_STAANQ6GIC1, ADDA_STAARQ6GAV9, ADDA_STAAS
A8Z073, ADDA_STAATQ8NXE9, ADDA_STAAWB9DIS2, ADDA_STACT
Q5HQJ4, ADDA_STAEQQ8CPT9, ADDA_STAESQ4L4Y3, ADDA_STAHJ
Q49WA6, ADDA_STAS1Q3K1I4, ADDA_STRA1Q8E5T9, ADDA_STRA3
Q8E061, ADDA_STRA5B4U2H1, ADDA_STREMA8AY33, ADDA_STRGC
Q8DT76, ADDA_STRMUQ9A0H3, ADDA_STRP1Q04KF8, ADDA_STRP2
P0CZ52, ADDA_STRP3B5E4P5, ADDA_STRP4Q5XCW6, ADDA_STRP6
Q8P1J2, ADDA_STRP8Q1JCJ8, ADDA_STRPBQ1JMH5, ADDA_STRPC
Q1JHM1, ADDA_STRPDQ1J7E4, ADDA_STRPFA2RFA8, ADDA_STRPG
B1IBR6, ADDA_STRPIB8ZQ32, ADDA_STRPJQ48UB8, ADDA_STRPM
Q97QP9, ADDA_STRPNP0CZ53, ADDA_STRPQB2IPX3, ADDA_STRPS
B5XKR4, ADDA_STRPZQ8DPR6, ADDA_STRR6A4W0M7, ADDA_STRS2
C0MGY6, ADDA_STRS7A3CNT9, ADDA_STRSVA4VUD2, ADDA_STRSY
Q5LY80, ADDA_STRT1Q5M2T7, ADDA_STRT2Q03IZ8, ADDA_STRTD
B9DRV0, ADDA_STRU0Q67MD5, ADDA_SYMTHQ0AXU8, ADDA_SYNWW
B0KDB7, ADDA_THEP3B0K213, ADDA_THEPXE1BNG3, ASCC3_BOVIN
F1NTD6, ASCC3_CHICKE7F8F4, ASCC3_DANREQ54G57, ASCC3_DICDI
Q8N3C0, ASCC3_HUMANE9PZJ8, ASCC3_MOUSEF1LPQ2, ASCC3_RAT
O18017, BLM_CAEELQ9I920, BLM_CHICKQ9VGI8, BLM_DROME
P54132, BLM_HUMANO88700, BLM_MOUSEQ9DEY9, BLM_XENLA
F2XG53, CAS3_STRTRO75417, DPOLQ_HUMANQ1RMT1, ERCC3_BOVIN
Q5ZKK7, ERCC3_CHICKQ7ZVV1, ERCC3_DANREO00835, ERCC3_DICDI
Q02870, ERCC3_DROMEP19447, ERCC3_HUMANQ60HG1, ERCC3_MACFA
P49135, ERCC3_MOUSEQ5RA62, ERCC3_PONABQ4G005, ERCC3_RAT
O13768, ERCC3_SCHPOQ9VDA0, FANCM_DROMEF1ND48, FBH1_CHICK
Q8NFZ0, FBH1_HUMANQ8K2I9, FBH1_MOUSEQ9USU3, FBH1_SCHPO
P15038, HELD_ECOLIH2KY86, HELQ_CAEELQ9VSE2, HELQ_DROME
Q8TDG4, HELQ_HUMANQ2VPA6, HELQ_MOUSEQ9YFQ8, HELS_AERPE
P0DMI1, HELS_ARCFUA8MB76, HELS_CALMQQ5UYM9, HELS_HALMA
B0R7Q2, HELS_HALS3Q9HMV6, HELS_HALSAQ8TL39, HELS_METAC
Q0W6L1, HELS_METARA7IB61, HELS_METB6Q465R3, HELS_METBF
Q12WZ6, HELS_METBUQ58524, HELS_METJAQ8PZR7, HELS_METMA
O26901, HELS_METTHA6UN73, HELS_METVSQ3IU46, HELS_NATPD
Q9V0A9, HELS_PYRABA3MSA1, HELS_PYRCJO73946, HELS_PYRFU
O59025, HELS_PYRHOF0NDL2, HELS_SACI5Q97VY9, HELS_SACS2
D0KN27, HELS_SACS9Q4JC00, HELS_SULACQ974S1, HELS_SULTO
Q9HJX7, HELS_THEACQ5JGV6, HELS_THEKOQ97AI2, HELS_THEVO
Q58824, HERA_METJAQ8U1P0, HERA_PYRFUQ97WG8, HERA_SACS2
F2Z5Z6, HERA_SULACQ96YR7, HERA_SULTOA2PYH4, HFM1_HUMAN
D3Z4R1, HFM1_MOUSEA2RUV5, HFM1_XENTRP51979, HFM1_YEAST
Q12039, HMI1_YEASTO13983, HRQ1_SCHPOQ05549, HRQ1_YEAST
Q09811, HUS2_SCHPOQ57742, LHRC_METJAO27830, LHRC_METTH
Q88NV1, LHRC_PSEPKP95949, LHRC_SACS2Q4J8R1, LHRC_SULAC
P30015, LHR_ECOLIA0QT91, LHR_MYCS2P13894, LT_BFPYV
P14999, LT_POVBAP0DOJ4, LT_POVBGP03071, LT_POVBK
P24851, LT_POVBOP03075, LT_POVHAP03072, LT_POVJC
P0DOI7, LT_POVK3P0DOI6, LT_POVK6P0DOI5, LT_POVKI
P04008, LT_POVLYP0DOJ6, LT_POVM1P0DOJ5, LT_POVM3
P03073, LT_POVMAP12905, LT_POVMCP24597, LT_POVMK
Q3L6L5, LT_POVS1A8Y984, LT_POVSMA5HBG1, LT_POVWU
P03070, LT_SV40Q9SF37, MCM8_ARATHE1BPX4, MCM8_BOVIN
I0IUP3, MCM8_CHICKQ9UJA3, MCM8_HUMANQ9CWV1, MCM8_MOUSE
B8AZ14, MCM8_ORYSIB9FKM7, MCM8_ORYSJD3ZVK1, MCM8_RAT
Q5F310, MCM8_XENLAQ0V9Q6, MCM8_XENTRF4IFF3, MCM9_ARATH
F1N2W9, MCM9_BOVINI0IUP4, MCM9_CHICKF1QDI9, MCM9_DANRE
Q9NXL9, MCM9_HUMANQ2KHI9, MCM9_MOUSEB8B406, MCM9_ORYSI
Q69QA6, MCM9_ORYSJF1M5F3, MCM9_RATQ6NRM6, MCM9_XENLA
F6RIX4, MCM9_XENTRQ9VF30, MCMR_DROMEF0NF15, MCM_SACI5
Q9UXG1, MCM_SACS2Q4JAB7, MCM_SULACQ5D892, MER3_ARATH
B6DMK2, MER3_ORYSJQ9HE09, MFH2_SCHPOA1CS00, MPH1_ASPCL
A1D4V5, MPH1_ASPF1B0XMV6, MPH1_ASPFCQ4WKB5, MPH1_ASPFU
A2Q8R2, MPH1_ASPNCQ2URJ5, MPH1_ASPORQ0CWI2, MPH1_ASPTN
A6RIS1, MPH1_BOTFBQ5A1A0, MPH1_CANALQ6FPQ3, MPH1_CANGA
Q2HG76, MPH1_CHAGBQ1DY43, MPH1_COCIMQ6BRF0, MPH1_DEBHA
Q75AA7, MPH1_EREGSQ6CQX2, MPH1_KLULAQ7SDF3, MPH1_NEUCR
A3GH78, MPH1_PICSTA4RN08, MPH1_PYRO7Q9UT23, MPH1_SCHPO
A7EFH4, MPH1_SCLS1A7TSV4, MPH1_VANPOA6ZVS0, MPH1_YEAS7
P40562, MPH1_YEASTP50830, MRFA_BACSUA0A0H3DK98, PCRAS_MYCPB
P75438, PCRAS_MYCPNO34580, PCRA_BACSUP56255, PCRA_GEOSE
Q9S3Q0, PCRA_LEUCIP45612, PCRA_MYCCTP47486, PCRA_MYCGE
P75437, PCRA_MYCPNQ53727, PCRA_STAA8Q5HEL7, PCRA_STAAC
P64318, PCRA_STAAMP64319, PCRA_STAANQ6GFF2, PCRA_STAAR
Q6G828, PCRA_STAASQ8NVT1, PCRA_STAAWQ5HN29, PCRA_STAEQ
Q8CRT9, PCRA_STAESP94461, PRIA_BACSUQ45032, PRIA_BORBU
P57220, PRIA_BUCAIQ8KA15, PRIA_BUCAPQ9PLE5, PRIA_CHLMU
Q9Z6Y2, PRIA_CHLPNO84783, PRIA_CHLTRP17888, PRIA_ECOLI
P44647, PRIA_HAEINQ9ZKE4, PRIA_HELPJO25149, PRIA_HELPY
A6TGC5, PRIA_KLEP7Q5F6V8, PRIA_NEIG1P05445, PRIA_RHORT
Q1RI08, PRIA_RICBRQ92HH1, PRIA_RICCNQ4UL64, PRIA_RICFE
Q9ZD10, PRIA_RICPRQ68WJ4, PRIA_RICTYP74397, PRIA_SYNY3
Q9WY22, PRIA_THEMAO83258, PRIA_TREPAQ6E6J3, RAD25_ANTLO
Q8SSK1, RAD25_ENCCUA9CRJ7, RAD25_ENTBHQ5V5F7, RAD25_HALMA
Q9HPZ2, RAD25_HALSAC4V922, RAD25_VAIC1Q00578, RAD25_YEAST
O51578, RECB_BORBUP57529, RECB_BUCAIQ8K9A9, RECB_BUCAP
Q89AB3, RECB_BUCBPQ9PLT8, RECB_CHLMUQ9Z7G7, RECB_CHLPN
O84645, RECB_CHLTRP08394, RECB_ECOLIP45157, RECB_HAEIN
A0QS29, RECB_MYCS2P9WMQ2, RECB_MYCTOP9WMQ3, RECB_MYCTU
O50224, RECG_ACIFIO67837, RECG_AQUAEF4INA9, RECG_ARATH
O34942, RECG_BACSUO51528, RECG_BORBUB7UM74, RECG_ECO27
Q8XD86, RECG_ECO57P24230, RECG_ECOLIP43809, RECG_HAEIN
Q9ZJA1, RECG_HELPJO26051, RECG_HELPYP64323, RECG_MYCBO
O69460, RECG_MYCLEP9WMQ6, RECG_MYCTOP9WMQ7, RECG_MYCTU
Q9CMB4, RECG_PASMUO50581, RECG_STAA8Q5HGK6, RECG_STAAC
P64324, RECG_STAAMP64325, RECG_STAANQ6GHK8, RECG_STAAR
Q6G9Y6, RECG_STAASQ8NX11, RECG_STAAWQ5HPW4, RECG_STAEQ
Q8CSV3, RECG_STAESQ54900, RECG_STRPNQ55681, RECG_SYNY3
Q9WY48, RECG_THEMAP96130, RECG_TREPAA8WK63, RECQ1_CAEBR
Q9TXJ8, RECQ1_CAEELP46063, RECQ1_HUMANQ9Z129, RECQ1_MOUSE
Q5RF63, RECQ1_PONABQ6AYJ1, RECQ1_RATQ9FT73, RECQ2_ARATH
O94761, RECQ4_HUMANQ75NR7, RECQ4_MOUSEO94762, RECQ5_HUMAN
Q8VID5, RECQ5_MOUSED4ACP5, RECQ5_RATO34748, RECQ_BACSU
P15043, RECQ_ECOLIP71359, RECQ_HAEINQ9CL21, RECQ_PASMU
P40724, RECQ_SALTYP73421, RECQ_SYNY3P50729, RECS_BACSU
P57654, REP_BUCAIO51889, REP_BUCAPQ89A21, REP_BUCBP
P09980, REP_ECOLIP44804, REP_HAEINQ9L6S1, REP_SALTY
Q9FT74, RQL1_ARATHQ9FT72, RQL3_ARATHQ8L840, RQL4A_ARATH
Q9FT70, RQL4B_ARATHQ0WVW7, RQL5_ARATHQ9FT69, RQSIM_ARATH
A0R5E2, SFTH_MYCS2P35187, SGS1_YEASTD1KF50, SRS2L_ARATH
Q10213, SRS2_SCHPOP12954, SRS2_YEASTP0CT33, TLH1_SCHPO
Q1RKN3, TLH2_SCHPOP0A5A4, UVRD1_MYCBOQ9CD72, UVRD1_MYCLE
P9WMQ0, UVRD1_MYCTOP9WMQ1, UVRD1_MYCTUP64321, UVRD2_MYCBO
P53528, UVRD2_MYCLEP9WMP8, UVRD2_MYCTOP9WMP9, UVRD2_MYCTU
P03018, UVRD_ECOLIQ02322, UVRD_HAEINQ1RIP8, UVRD_RICBR
Q92HZ6, UVRD_RICCNQ4ULN5, UVRD_RICFEQ9ZD95, UVRD_RICPR
Q68WT1, UVRD_RICTYQ05311, UVRD_SALTYP0DXF1, UVSW_BPT4
P03116, VE1_BPV1P11298, VE1_BPV2Q8BDD7, VE1_BPV3
P08344, VE1_BPV4Q705G8, VE1_BPV5Q705F4, VE1_BPV6
Q89536, VE1_COPV6P03112, VE1_CRPVKP51894, VE1_CRPVW
P06455, VE1_FPVLP36719, VE1_HPV03Q07846, VE1_HPV04
P06920, VE1_HPV05Q05133, VE1_HPV07P06420, VE1_HPV08
Q05111, VE1_HPV09P03111, VE1_HPV1P36720, VE1_HPV10
P04014, VE1_HPV11Q05134, VE1_HPV12Q02261, VE1_HPV13
P36721, VE1_HPV14Q05135, VE1_HPV15P03114, VE1_HPV16
Q02512, VE1_HPV17P06789, VE1_HPV18Q02048, VE1_HPV19
P50758, VE1_HPV20P50759, VE1_HPV21P50760, VE1_HPV22
P50761, VE1_HPV23P50762, VE1_HPV24Q02049, VE1_HPV25
P36722, VE1_HPV26P36723, VE1_HPV27P50763, VE1_HPV28
P50764, VE1_HPV29P25481, VE1_HPV2AQ05112, VE1_HPV30
P17382, VE1_HPV31P36724, VE1_HPV32P06421, VE1_HPV33
P36725, VE1_HPV34P27220, VE1_HPV35P50808, VE1_HPV36
Q80902, VE1_HPV37Q80909, VE1_HPV38P24829, VE1_HPV39
P36727, VE1_HPV40P27551, VE1_HPV41P27221, VE1_HPV42
Q80915, VE1_HPV44P36728, VE1_HPV45P22419, VE1_HPV47
Q80922, VE1_HPV48P36729, VE1_HPV49P26544, VE1_HPV51
P36730, VE1_HPV52Q02513, VE1_HPV53Q81020, VE1_HPV54
P22153, VE1_HPV57P26543, VE1_HPV58Q81966, VE1_HPV59
P26542, VE1_HPV5BQ80943, VE1_HPV60Q80950, VE1_HPV61
Q07847, VE1_HPV63Q07848, VE1_HPV65Q80957, VE1_HPV66
Q9JH49, VE1_HPV69Q84293, VE1_HPV6AP03113, VE1_HPV6B
P50765, VE1_HPV70Q81999, VE1_HPV72Q82007, VE1_HPV73
O40619, VE1_HPVR7P22154, VE1_MMPV1Q84356, VE1_MNPVA
P03117, VE1_OVPVDP11328, VE1_PAPVEQ02262, VE1_PCPV1
P81174, VE1_PCPVCQ19546, WRN_CAEELQ14191, WRN_HUMAN
O09053, WRN_MOUSEO93530, WRN_XENLAQ38861, XPB1_ARATH
Q971U1, XPB1_SULTOQ9FUG4, XPB2_ARATHQ970I2, XPB2_SULTO
Q381F9, XPBR_TRYB2O29889, XPB_ARCFUA6WE36, XPB_KINRD
O53873, XPB_MYCTUQ580W5, XPB_TRYB2P13010, XRCC5_HUMAN
P27641, XRCC5_MOUSEQ6DDS9, XRCC5_XENLAO93257, XRCC6_CHICK
P12956, XRCC6_HUMANP23475, XRCC6_MOUSEQ58884, Y1489_METJA
Q58960, Y1565_METJAQ60270, Y3508_METJAQ60275, Y3513_METJA
Q57809, Y363_METJAQ58371, Y961_METJAO31626, YJCD_BACSU
Q5UR49, YR568_MIMIV
BRENDA5.6.2.4
MetaCyc5.6.2.4
KEGG Ligand Database for Enzyme Nomenclature5.6.2.4
MEDLINEFind literature relating to 5.6.2.4

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