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ENZYME entry: EC 6.1.1.26

Accepted Name
Pyrrolysine--tRNA(Pyl) ligase.
Alternative Name(s)
PylRS.
Pyrrolysyl-tRNA synthetase.
Reaction catalysed
ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)
Comment(s)
  • In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl- -tRNA ligase.
  • Specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
Cross-references
BRENDA6.1.1.26
EC2PDB6.1.1.26
ExplorEnz6.1.1.26
PRIAM enzyme-specific profiles6.1.1.26
KEGG Ligand Database for Enzyme Nomenclature6.1.1.26
IUBMB Enzyme Nomenclature6.1.1.26
IntEnz6.1.1.26
MEDLINEFind literature relating to 6.1.1.26
MetaCyc6.1.1.26
Rhea expert-curated reactions6.1.1.26
UniProtKB/Swiss-Prot
Q8TUB8, PYLS_METAC;  Q6WRH6, PYLS_METBA;  Q46E77, PYLS_METBF;  
Q12UB6, PYLS_METBU;  Q8PWY1, PYLS_METMA;  Q1L6A3, PYLS_METTE;  

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