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ENZYME entry: EC 6.1.2.2

Accepted Name
Nebramycin 5' synthase.
Alternative Name(s)
Tobramycin carbamoyltransferase.
Reaction catalysed
  • Tobramycin + carbamoyl phosphate + ATP + H(2)O <=> nebramycin 5' + AMP + diphosphate + phosphate
  • Kanamycin A + carbamoyl phosphate + ATP + H(2)O <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate
Cofactor(s)
Fe(3+).
Comment(s)
  • The enzyme from the bacterium Streptoalloteichus tenebrarius catalyzes the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin.
  • Formerly EC 2.1.3.13 and EC 2.1.3.14.
Cross-references
BRENDA6.1.2.2
EC2PDB6.1.2.2
ExplorEnz6.1.2.2
PRIAM enzyme-specific profiles6.1.2.2
KEGG Ligand Database for Enzyme Nomenclature6.1.2.2
IUBMB Enzyme Nomenclature6.1.2.2
IntEnz6.1.2.2
MEDLINEFind literature relating to 6.1.2.2
MetaCyc6.1.2.2
Rhea expert-curated reactions6.1.2.2
UniProtKB/Swiss-Prot
Q70IY1, TOBZ_STRSD

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