ENZYME entry: EC 6.1.2.2
Accepted Name |
Nebramycin 5' synthase.
|
Alternative Name(s) |
Tobramycin carbamoyltransferase. |
Reaction catalysed |
- Tobramycin + carbamoyl phosphate + ATP + H(2)O <=> nebramycin 5' + AMP + diphosphate + phosphate
- Kanamycin A + carbamoyl phosphate + ATP + H(2)O <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate
|
Cofactor(s) |
Fe(3+).
|
Comment(s) |
- The enzyme from the bacterium Streptoalloteichus tenebrarius
catalyzes the activation of carbamoyl phosphate to
O-carbamoyladenylate and the subsequent carbamoylation of kanamycin
and tobramycin.
- Formerly EC 2.1.3.13 and EC 2.1.3.14.
|
Cross-references |
BRENDA | 6.1.2.2 |
EC2PDB | 6.1.2.2 |
ExplorEnz | 6.1.2.2 |
PRIAM enzyme-specific profiles | 6.1.2.2 |
KEGG Ligand Database for Enzyme Nomenclature | 6.1.2.2 |
IUBMB Enzyme Nomenclature | 6.1.2.2 |
IntEnz | 6.1.2.2 |
MEDLINE | Find literature relating to 6.1.2.2 |
MetaCyc | 6.1.2.2 |
UniProtKB/Swiss-Prot |
|
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