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ENZYME entry: EC 6.2.1.36

Accepted Name
3-hydroxypropionyl-CoA synthase.
Alternative Name(s)
3-hydroxypropionate--CoA ligase.
3-hydroxypropionyl-CoA synthetase (AMP-forming).
Reaction catalysed
3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate
Comment(s)
  • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea.
  • The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propanoate, acrylate, acetate, and butanoate as substrates, and are thus different from EC 6.2.1.17, which does not accept acetate or butanoate.
Cross-references
BRENDA6.2.1.36
EC2PDB6.2.1.36
ExplorEnz6.2.1.36
PRIAM enzyme-specific profiles6.2.1.36
KEGG Ligand Database for Enzyme Nomenclature6.2.1.36
IUBMB Enzyme Nomenclature6.2.1.36
IntEnz6.2.1.36
MEDLINEFind literature relating to 6.2.1.36
MetaCyc6.2.1.36
Rhea expert-curated reactions6.2.1.36
UniProtKB/Swiss-Prot
A4YGR1, HPCAS_METS5;  Q973W5, HPCAS_SULTO;  

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