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ENZYME entry: EC 6.2.1.52

Accepted Name
L-firefly luciferin--CoA ligase.
Reaction catalysed
ATP + L-firefly luciferin + CoA <=> AMP + diphosphate + L-firefly luciferyl-CoA
Comment(s)
  • This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate.
  • The D-isomer can act as a substrate for the CoA--ligase activity in vitro only under low oxygen conditions that are not found in vivo.
  • The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission.
Cross-references
BRENDA6.2.1.52
EC2PDB6.2.1.52
ExplorEnz6.2.1.52
PRIAM enzyme-specific profiles6.2.1.52
KEGG Ligand Database for Enzyme Nomenclature6.2.1.52
IUBMB Enzyme Nomenclature6.2.1.52
IntEnz6.2.1.52
MEDLINEFind literature relating to 6.2.1.52
MetaCyc6.2.1.52

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-