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ENZYME entry: EC 6.2.1.59

Accepted Name
Long-chain fatty acid adenylase/transferase FadD26.
Alternative Name(s)
FadD26.
Reaction catalysed
ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase]
Comment(s)
  • The enzyme, present in pathogenic species of mycobacteria, participates in the pathway for biosynthesis of phthiocerols.
  • It catalyzes the adenylation of the long-chain fatty acids arachidate (C(20)) or behenate (C(22)) and potentially the very-long-chain fatty acid lignocerate (C(24)).
  • The activated fatty acids are then loaded to EC 2.3.1.292.
Cross-references
BRENDA6.2.1.59
EC2PDB6.2.1.59
ExplorEnz6.2.1.59
PRIAM enzyme-specific profiles6.2.1.59
KEGG Ligand Database for Enzyme Nomenclature6.2.1.59
IUBMB Enzyme Nomenclature6.2.1.59
IntEnz6.2.1.59
MEDLINEFind literature relating to 6.2.1.59
MetaCyc6.2.1.59
UniProtKB/Swiss-Prot
Q7TXM1, FAA26_MYCBO;  B2HIN2, FAA26_MYCMM;  P9WQ42, FAA26_MYCTO;  
P9WQ43, FAA26_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-