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ENZYME entry: EC 6.2.1.65

Accepted Name
Salicylate--CoA ligase.
Reaction catalysed
ATP + salicylate + CoA <=> AMP + diphosphate + 2-hydroxybenzoyl-CoA
Comment(s)
  • The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway.
  • It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
Cross-references
BRENDA6.2.1.65
EC2PDB6.2.1.65
ExplorEnz6.2.1.65
PRIAM enzyme-specific profiles6.2.1.65
KEGG Ligand Database for Enzyme Nomenclature6.2.1.65
IUBMB Enzyme Nomenclature6.2.1.65
IntEnz6.2.1.65
MEDLINEFind literature relating to 6.2.1.65
MetaCyc6.2.1.65
Rhea expert-curated reactions6.2.1.65
UniProtKB/Swiss-Prot
Q7X279, SDGA_STRSQ

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