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ENZYME entry: EC 6.2.1.76

Accepted Name
malonate--CoA ligase.
Reaction catalysed
ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA
Comment(s)
  • The enzyme, found in mitochondria, detoxifies malonate, which is a potent inhibitor of mitochondrial respiration, and provides malonyl- CoA to the mitochondrial fatty acid biosynthesis pathway.
  • Formerly EC 6.2.1.n3.
Cross-references
BRENDA6.2.1.76
EC2PDB6.2.1.76
ExplorEnz6.2.1.76
PRIAM enzyme-specific profiles6.2.1.76
KEGG Ligand Database for Enzyme Nomenclature6.2.1.76
IUBMB Enzyme Nomenclature6.2.1.76
IntEnz6.2.1.76
MEDLINEFind literature relating to 6.2.1.76
MetaCyc6.2.1.76
Rhea expert-curated reactions6.2.1.76
UniProtKB/Swiss-Prot
Q8H151, AAE13_ARATH;  Q58DN7, ACSF3_BOVIN;  Q4G176, ACSF3_HUMAN;  
Q3URE1, ACSF3_MOUSE;  Q6GLK6, ACSF3_XENLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-