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ENZYME entry: EC

Accepted Name
Thioglycine synthase.
Reaction catalysed
ATP + sulfide + a [methyl-coenzyme M reductase]-glycine <=> ADP + phosphate + a [methyl-coenzyme M reductase]-thioglycine
  • Requires Mg(2+).
  • The enzyme is found in anaerobic methanogenic and methanotrophic archaea, where it modifies a glycine residue in EC
  • Upon binding to its substrate, an external source of sulfide attacks the target amide bond generating a tetrahedral intermediate.
  • The amide oxyanion attacks the gamma-phosphate of ATP, releasing ADP and forming a phosphorylated thiolate intermediate that collapses to form thioglycine and phosphate.
  • In most organisms activity requires a second protein (TfuA) , which may allosterically activate this enzyme or assist in the delivery of sulfide to the substrate.
PRIAM enzyme-specific profiles6.2.2.1
KEGG Ligand Database for Enzyme Nomenclature6.2.2.1
IUBMB Enzyme Nomenclature6.2.2.1
MEDLINEFind literature relating to
Rhea expert-curated reactions6.2.2.1

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